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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004878naa a2200685 4500
001oai:DiVA.org:hkr-15026
003SwePub
008151118s2015 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:fb902a8d-3290-40ff-a72e-d4e1299c4883
009oai:prod.swepub.kib.ki.se:132932044
0247 a urn:nbn:se:hkr:diva-150262 urn
0247 a https://doi.org/10.1111/all.128052 DOI
0247 a https://lup.lub.lu.se/record/82360302 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1329320442 URI
040 a (SwePub)hkrd (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Henmyr, Viktor4 aut
2451 0a Characterization of genetic variation in TLR8 in relation to allergic rhinitis
264 1b Wiley-Blackwell,c 2015
338 a print2 rdacarrier
506 a restricted
520 a BACKGROUND: A previous investigation of all 10 TLR-genes for associations with allergic rhinitis (AR) detected a number of significant SNPs in the TLR8 locus. The associations indicated that an accumulation of rare variants could explain the signal. The present study therefore searches for rare variants in the TLR8 region and also investigates the reproducibility of previous SNP associations.METHODS: The TLR8 gene was re-sequenced in 288 AR patients from Malmö and the data was compared with publically available data. Seven previously AR-associated SNPs from TLR8 were analyzed for AR-associations in 422 AR patients and 859 controls from the BAMSE cohort. The associations detected in present and previous studies were compared.RESULTS: Sequencing detected 13 polymorphisms (3 promotor, 10 coding) among 288 AR patients. Four of the coding polymorphisms were rare (MAF <1%) and three of those were novel. Two coding polymorphisms were benign missense mutations and the rest were synonymous. Comparison with 1000Genomes and Exome Aggregation Consortium data revealed no accumulation of rare variants in the AR cases. The AR-association tests made using the BAMSE cohort yielded 5 P-values < 0.05. Tests of IgE-levels yielded 4 significant SNP associations to birch pollen. Comparing results between different populations revealed opposing risk alleles, different gender effects and response to different allergens in the different populations.CONCLUSIONS: Rare variants in TLR8 are not associated with AR. Comparison of present and previous association studies reveal contradictory results for common variants. Thus, no associations exist between genetic variation in TLR8 and AR. This article is protected by copyright. All rights reserved.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
653 a Adolescents
653 a depression
653 a school-based program
653 a prevention
653 a cognitive behavior program
7001 a Lind-Halldén, Christina4 aut
7001 a Carlberg, Daniel4 aut
7001 a Halldén, Christer4 aut
7001 a Melén, Eu Karolinska institutet4 aut
7001 a Wickman, Mu Karolinska Institutet4 aut
7001 a Bergström, Au Karolinska institutet4 aut
7001 a Säll, Tu Lund University4 aut
7001 a Cardell, L Ou Karolinska institutet4 aut
7001 a Säll, Torbjörnu Lund University,Lunds universitet,Molekylär cellbiologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Molecular Cell Biology,Department of Biology,Faculty of Science4 aut0 (Swepub:lu)gen-tsa
7001 a Halldén, C4 aut
7001 a Carlberg, D4 aut
7001 a Lind-Halldén, C4 aut
7001 a Henmyr, V4 aut
7001 a Sall, T4 aut
7001 a Hallden, C4 aut
7001 a Lind-Hallden, C4 aut
7001 a Cardell, LOu Karolinska Institutet4 aut
7001 a Bergstrom, Au Karolinska Institutet4 aut
7001 a Melen, Eu Karolinska Institutet4 aut
7102 a Karolinska Institutetb Karolinska institutet4 org
7730 t Allergy. European Journal of Allergy and Clinical Immunologyd : Wiley-Blackwellx 0105-4538x 1398-9995
8564 u http://dx.doi.org/10.1111/all.12805y FULLTEXT
8564 8u http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-15026x lärosäteslänky Till lärosätets (hkr) databas
8564 8u https://doi.org/10.1111/all.12805
8564 8u https://lup.lub.lu.se/record/8236030
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:132932044

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