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  • He, ShizhenKarolinska Inst, Inst Environm Med, Nobels Vag 13,Box 210, SE-17177 Stockholm, Sweden. (författare)

Ambient air pollution and inflammation-related proteins during early childhood

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • Elsevier,2022
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-488557
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-488557URI
  • https://doi.org/10.1016/j.envres.2022.114364DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:151127303URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background and aim: Experimental studies show that short-term exposure to air pollution may alter cytokine concentrations. There is, however, a lack of epidemiological studies evaluating the association between long-term air pollution exposure and inflammation-related proteins in young children. Our objective was to examine whether air pollution exposure is associated with inflammation-related proteins during the first 2 years of life. Methods: In a pooled analysis of two birth cohorts from Stockholm County (n = 158), plasma levels of 92 systemic inflammation-related proteins were measured by Olink Proseek Multiplex Inflammation panel at 6 months, 1 year and 2 years of age. Time-weighted average exposure to particles with an aerodynamic diameter of <10 mu m (PM10), <2.5 mu m (PM2.5), and nitrogen dioxide (NO2) at residential addresses from birth and onwards was estimated via validated dispersion models. Stratified by sex, longitudinal cross-referenced mixed effect models were applied to estimate the overall effect of preceding air pollution exposure on combined protein levels, "inflammatory proteome", over the first 2 years of life, followed by cross-sectional protein-specific bootstrapped quantile regression analysis. Results: We identified significant longitudinal associations of inflammatory proteome during the first 2 years of life with preceding PM2.5 exposure, while consistent associations with PM10 and NO2 across ages were only observed among girls. Subsequent protein-specific analyses revealed significant associations of PM10 exposure with an increase in IFN-gamma and IL-12B in boys, and a decrease in IL-8 in girls at different percentiles of proteins levels, at age 6 months. Several inflammation-related proteins were also significantly associated with preceding PM10, PM2.5 and NO2 exposures, at ages 1 and 2 years, in a sex-specific manner. Conclusions: Ambient air pollution exposure influences inflammation-related protein levels already during early childhood. Our results also suggest age-and sex-specific differences in the impact of air pollution on children's inflammatory profiles.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Klevebro, SusannaKarolinska Institutet,Soder Sjukhuset, Karolinska Inst, Dept Clin Sci & Educ, Stockholm, Sweden.;Soder Sjukhuset, Sachs Children & Youth Hosp, Stockholm, Sweden. (författare)
  • Baldanzi, GabrielUppsala universitet,Molekylär epidemiologi,Karolinska Inst, Inst Environm Med, Nobels Vag 13,Box 210, SE-17177 Stockholm, Sweden.(Swepub:uu)gabba126 (författare)
  • Pershagen, GoranKarolinska Institutet,Karolinska Inst, Inst Environm Med, Nobels Vag 13,Box 210, SE-17177 Stockholm, Sweden.;Reg Stockholm, Ctr Occupat & Environm Med, Stockholm, Sweden. (författare)
  • Lundberg, BjornKarolinska Institutet,Soder Sjukhuset, Karolinska Inst, Dept Clin Sci & Educ, Stockholm, Sweden.;Soder Sjukhuset, Sachs Children & Youth Hosp, Stockholm, Sweden. (författare)
  • Eneroth, KristinaSLB Anal, Environm & Hlth Adm, Stockholm, Sweden. (författare)
  • Hedman, Anna M.Karolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden. (författare)
  • Andolf, EllikaKarolinska Institutet,Danderyd Hosp, Karolinska Inst, Dept Clin Sci, Stockholm, Sweden. (författare)
  • Almqvist, CatarinaKarolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.;Karolinska Univ Hosp, Astrid Lindgren Childrens Hosp, Pediat Allergy & Pulmonol Unit, Stockholm, Sweden. (författare)
  • Bottai, MatteoKarolinska Institutet,Karolinska Inst, Inst Environm Med, Nobels Vag 13,Box 210, SE-17177 Stockholm, Sweden. (författare)
  • Melen, ErikKarolinska Institutet,Soder Sjukhuset, Karolinska Inst, Dept Clin Sci & Educ, Stockholm, Sweden.;Soder Sjukhuset, Sachs Children & Youth Hosp, Stockholm, Sweden. (författare)
  • Gruzieva, OlenaKarolinska Institutet,Karolinska Inst, Inst Environm Med, Nobels Vag 13,Box 210, SE-17177 Stockholm, Sweden.;Reg Stockholm, Ctr Occupat & Environm Med, Stockholm, Sweden. (författare)
  • Karolinska InstitutetKarolinska Inst, Inst Environm Med, Nobels Vag 13,Box 210, SE-17177 Stockholm, Sweden. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Environmental Research: Elsevier2150013-93511096-0953

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