Sökning: WFRF:(Magnusson Patrik K.) > A multi-ancestry ge...
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000 | 14976naa a2203841 4500 | |
001 | oai:DiVA.org:umu-166416 | |
003 | SwePub | |
008 | 191216s2019 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:142200157 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1664162 URI |
024 | 7 | a https://doi.org/10.1093/hmg/ddz0702 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1422001572 URI |
040 | a (SwePub)umud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Sung, Yun Ju4 aut |
245 | 1 0 | a A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure |
264 | c 2019-04-10 | |
264 | 1 | b Oxford University Press,c 2019 |
338 | a print2 rdacarrier | |
520 | a Elevated blood pressure (BP), a leading cause of global morbidity and mortality, is influenced by both genetic and lifestyle factors. Cigarette smoking is one such lifestyle factor. Across five ancestries, we performed a genome-wide gene–smoking interaction study of mean arterial pressure (MAP) and pulse pressure (PP) in 129 913 individuals in stage 1 and follow-up analysis in 480 178 additional individuals in stage 2. We report here 136 loci significantly associated with MAP and/or PP. Of these, 61 were previously published through main-effect analysis of BP traits, 37 were recently reported by us for systolic BP and/or diastolic BP through gene–smoking interaction analysis and 38 were newly identified (P < 5 × 10−8, false discovery rate < 0.05). We also identified nine new signals near known loci. Of the 136 loci, 8 showed significant interaction with smoking status. They include CSMD1 previously reported for insulin resistance and BP in the spontaneously hypertensive rats. Many of the 38 new loci show biologic plausibility for a role in BP regulation. SLC26A7 encodes a chloride/bicarbonate exchanger expressed in the renal outer medullary collecting duct. AVPR1A is widely expressed, including in vascular smooth muscle cells, kidney, myocardium and brain. FHAD1 is a long non-coding RNA overexpressed in heart failure. TMEM51 was associated with contractile function in cardiomyocytes. CASP9 plays a central role in cardiomyocyte apoptosis. Identified only in African ancestry were 30 novel loci. Our findings highlight the value of multi-ancestry investigations, particularly in studies of interaction with lifestyle factors, where genomic and lifestyle differences may contribute to novel findings. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
653 | a smoking | |
653 | a hypertension | |
653 | a genes | |
653 | a genome | |
653 | a life style | |
653 | a genetics | |
653 | a kidney | |
653 | a mean arterial pressure | |
653 | a blood pressure regulation | |
653 | a pulse pressure | |
653 | a genome-wide association study | |
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700 | 1 | a Pedersen, Nancy L.u Karolinska Institutet4 aut |
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700 | 1 | a Renström, Fridau Umeå universitet,Enheten för biobanksforskning,Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden4 aut0 (Swepub:umu)frre0001 |
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700 | 1 | a Franks, Paul W.u Umeå universitet,Avdelningen för medicin,Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden; Harvard T. H. Chan School of Public Health, Department of Nutrition, Harvard University, Boston, MA, USA4 aut0 (Swepub:umu)pafr0003 |
700 | 1 | a Rice, Kenneth4 aut |
700 | 1 | a Elliott, Paul4 aut |
700 | 1 | a Caulfield, Mark J.4 aut |
700 | 1 | a Gauderman, W. James4 aut |
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710 | 2 | a Karolinska Institutetb Enheten för biobanksforskning4 org |
773 | 0 | t Human Molecular Geneticsd : Oxford University Pressg 28:15, s. 2615-2633q 28:15<2615-2633x 0964-6906x 1460-2083 |
856 | 4 | u https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644157/pdf/ddz070.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-166416 |
856 | 4 8 | u https://doi.org/10.1093/hmg/ddz070 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:142200157 |
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