WFRF:(Martin Broto J.)
Sökning: WFRF:(Martin Broto J.) > Efficacy of immune ...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05798naa a2200649 4500 | |
| 001 | oai:lup.lub.lu.se:1ede7563-37b1-4de7-adae-2096dcfb68ba | |
| 003 | SwePub | |
| 008 | 231221s2023 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/1ede7563-37b1-4de7-adae-2096dcfb68ba2 URI |
| 024 | 7 | a https://doi.org/10.1016/j.esmoop.2023.1020452 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Hindi, N.u Health Research Institute Jiménez Díaz Foundation,Hospital Fundación Jiménez Díaz4 aut |
| 245 | 1 0 | a Efficacy of immune checkpoint inhibitors in alveolar soft-part sarcoma : results from a retrospective worldwide registry |
| 264 | 1 | c 2023 |
| 520 | a Background: Conventional cytotoxic drugs are not effective in alveolar soft-part sarcoma (ASPS). Immune checkpoint (programmed cell death protein 1/programmed death-ligand 1) inhibitors (ICIs) are promising drugs in ASPS. A worldwide registry explored the efficacy of ICI in ASPS. Materials and methods: Data from adult patients diagnosed with ASPS and treated with ICI for advanced disease in expert sarcoma centers from Europe, Australia and North America were retrospectively collected, including demographics and data related to treatments and outcome. Results: Seventy-six ASPS patients, with a median age at diagnosis of 25 years (range 3-61 years), were registered. All patients received ICI for metastatic disease. Immunotherapy regimens consisted of monotherapy in 38 patients (50%) and combination in 38 (50%) (23 with a tyrosine kinase inhibitor). Among the 68 assessable patients, there were 3 complete responses and 34 partial responses, translating into an overall response rate of 54.4%. After a median follow-up of 36 months [95% confidence interval (CI) 32-40 months] since the start of immunotherapy, 45 (59%) patients have progressed on ICI, with a median progression-free survival (PFS) of 16.3 months (95% CI 8-25 months). Receiving ICI in first line (P = 0.042) and achieving an objective response (P = 0.043) correlated with a better PFS. Median estimated overall survival (OS) from ICI initiation has not been reached. The 12-month and 24-month OS rates were 94% and 81%, respectively. Conclusions: This registry constitutes the largest available series of ASPS treated with ICI. Our results suggest that the ICI treatment provides long-lasting disease control and prolonged OS in patients with advanced ASPS, an ultra-rare entity with limited active therapeutic options. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 653 | a alveolar soft-part sarcoma | |
| 653 | a immune checkpoint | |
| 653 | a immunotherapy | |
| 653 | a progression-free survival | |
| 700 | 1 | a Razak, A.u Princess Margaret Hospital University of Toronto4 aut |
| 700 | 1 | a Rosembaum, E.u Memorial Sloan-Kettering Cancer Center4 aut |
| 700 | 1 | a Jonczak, E.u University of Miami4 aut |
| 700 | 1 | a Hamacher, R.u University Hospital Essen4 aut |
| 700 | 1 | a Rutkowski, P.u The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology4 aut |
| 700 | 1 | a Bhadri, V. A.u Cancer Institute of New South Wales4 aut |
| 700 | 1 | a Skryd, A.u University of Miami4 aut |
| 700 | 1 | a Brahmi, M.u Claude Bernard University Lyon 14 aut |
| 700 | 1 | a Alshibany, A.u Princess Margaret Hospital University of Toronto4 aut |
| 700 | 1 | a Jagodzinska-Mucha, P.u The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology4 aut |
| 700 | 1 | a Bauer, S.u University Hospital Essen4 aut |
| 700 | 1 | a Connolly, Emmau Cancer Institute of New South Wales4 aut |
| 700 | 1 | a Gelderblom, H.u Leiden University Medical Centre4 aut |
| 700 | 1 | a Boye, K.u Oslo university hospital4 aut |
| 700 | 1 | a Henon, C.u Institut Gustave Roussy4 aut |
| 700 | 1 | a Bae, S.u Peter MacCallum Cancer Centre4 aut |
| 700 | 1 | a Bogefors, K.u Lund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lymfom - Klinisk forskning,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lymphoma - Clinical Research,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital4 aut0 (Swepub:lu)med-kbf |
| 700 | 1 | a Vincenzi, B.u University Campus Bio-Medico4 aut |
| 700 | 1 | a Martinez-Trufero, J.u Miguel Servet University Hospital4 aut |
| 700 | 1 | a Lopez-Martin, J. A.u 12 de Octubre University Hospital4 aut |
| 700 | 1 | a Redondo, A.u University Hospital La Paz4 aut |
| 700 | 1 | a Valverde, C.u Vall d'Hebron University Hospital4 aut |
| 700 | 1 | a Blay, J. Y.u Claude Bernard University Lyon 14 aut |
| 700 | 1 | a Moura, D. S.u Health Research Institute Jiménez Díaz Foundation4 aut |
| 700 | 1 | a Gutierrez, A.u Hospital Universitario Son Espases4 aut |
| 700 | 1 | a Tap, W.u Memorial Sloan-Kettering Cancer Center4 aut |
| 700 | 1 | a Martin-Broto, Javieru Hospital Fundación Jiménez Díaz,Health Research Institute Jiménez Díaz Foundation4 aut |
| 710 | 2 | a Health Research Institute Jiménez Díaz Foundationb Hospital Fundación Jiménez Díaz4 org |
| 773 | 0 | t ESMO Openg 8:6q 8:6x 2059-7029 |
| 856 | 4 | u http://dx.doi.org/10.1016/j.esmoop.2023.102045x freey FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/1ede7563-37b1-4de7-adae-2096dcfb68ba |
| 856 | 4 8 | u https://doi.org/10.1016/j.esmoop.2023.102045 |
Hitta mer i SwePub
- Av författaren/redakt...
- Hindi, N.
- Razak, A.
- Rosembaum, E.
- Jonczak, E.
- Hamacher, R.
- Rutkowski, P.
- visa fler...
- Bhadri, V. A.
- Skryd, A.
- Brahmi, M.
- Alshibany, A.
- Jagodzinska-Much ...
- Bauer, S.
- Connolly, Emma
- Gelderblom, H.
- Boye, K.
- Henon, C.
- Bae, S.
- Bogefors, K.
- Vincenzi, B.
- Martinez-Trufero ...
- Lopez-Martin, J. ...
- Redondo, A.
- Valverde, C.
- Blay, J. Y.
- Moura, D. S.
- Gutierrez, A.
- Tap, W.
- Martin-Broto, Ja ...
- visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- och Cancer och onkol ...
- Artiklar i publikationen
- ESMO Open
- Av lärosätet
- Lunds universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
