WFRF:(McLaren S)
Sökning: WFRF:(McLaren S) > (2015-2019) > Patterns and predic...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 08329naa a2201153 4500 | |
| 001 | oai:gup.ub.gu.se/266334 | |
| 003 | SwePub | |
| 008 | 240528s2018 | |||||||||||000 ||eng| | |
| 009 | oai:lup.lub.lu.se:b5af0956-5f33-464b-a969-bead190d3d1b | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2663342 URI |
| 024 | 7 | a https://doi.org/10.1136/annrheumdis-2017-2119122 DOI |
| 024 | 7 | a https://lup.lub.lu.se/record/b5af0956-5f33-464b-a969-bead190d3d1b2 URI |
| 040 | a (SwePub)gud (SwePub)lu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Herrick, A. L.u University of Manchester,Christie NHS Foundation Trust4 aut |
| 245 | 1 0 | a Patterns and predictors of skin score change in early diffuse systemic sclerosis from the European Scleroderma Observational Study |
| 264 | c 2018-01-06 | |
| 264 | 1 | b BMJ,c 2018 |
| 520 | a Objectives Our aim was to use the opportunity provided by the European Scleroderma Observational Study to (1) identify and describe those patients with early diffuse cutaneous systemic sclerosis (dcSSc) with progressive skin thickness, and (2) derive prediction models for progression over 12 months, to inform future randomised controlled trials (RCTs). Methods The modified Rodnan skin score (mRSS) was recorded every 3 months in 326 patients. 'Progressors' were defined as those experiencing a 5-unit and 25% increase in mRSS score over 12 months (±3 months). Logistic models were fitted to predict progression and, using receiver operating characteristic (ROC) curves, were compared on the basis of the area under curve (AUC), accuracy and positive predictive value (PPV). Results 66 patients (22.5%) progressed, 227 (77.5%) did not (33 could not have their status assessed due to insufficient data). Progressors had shorter disease duration (median 8.1 vs 12.6 months, P=0.001) and lower mRSS (median 19 vs 21 units, P=0.030) than non-progressors. Skin score was highest, and peaked earliest, in the anti-RNA polymerase III (Pol3+) subgroup (n=50). A first predictive model (including mRSS, duration of skin thickening and their interaction) had an accuracy of 60.9%, AUC of 0.666 and PPV of 33.8%. By adding a variable for Pol3 positivity, the model reached an accuracy of 71%, AUC of 0.711 and PPV of 41%. Conclusions Two prediction models for progressive skin thickening were derived, for use both in clinical practice and for cohort enrichment in RCTs. These models will inform recruitment into the many clinical trials of dcSSc projected for the coming years. Trial registration number NCT02339441. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng |
| 653 | a autoantibodies | |
| 653 | a outcomes research | |
| 653 | a systemic sclerosis | |
| 700 | 1 | a Peytrignet, S.u University of Manchester4 aut |
| 700 | 1 | a Lunt, M.u University of Manchester4 aut |
| 700 | 1 | a Pan, X.u University of Manchester4 aut |
| 700 | 1 | a Hesselstrand, Rogeru Lund University,Lunds universitet,Forskargruppen för systemisk skleros, Lund,Forskargrupper vid Lunds universitet,Lund Systemic Sclerosis Research Group,Lund University Research Groups4 aut0 (Swepub:lu)reum-rhe |
| 700 | 1 | a Mouthon, L.u Paris Descartes University,University Medical Center Utrecht4 aut |
| 700 | 1 | a Silman, A. J.u University of Oxford4 aut |
| 700 | 1 | a Dinsdale, G.u University of Manchester4 aut |
| 700 | 1 | a Brown, E.u University of Manchester4 aut |
| 700 | 1 | a Czirják, L.u University of Pécs4 aut |
| 700 | 1 | a Distler, J. H. W.u Friedrich-Alexander University Erlangen-Nürnberg,Gateshead Hospitals Foundation Trust4 aut |
| 700 | 1 | a Distler, O.u University of Zurich4 aut |
| 700 | 1 | a Fligelstone, K.u Royal Free London NHS Foundation Trust4 aut |
| 700 | 1 | a Gregory, W. J.u Salford Royal NHS Foundation Trust4 aut |
| 700 | 1 | a Ochiel, R.u Royal Free London NHS Foundation Trust4 aut |
| 700 | 1 | a Vonk, M. C.u Radboud University Nijmegen4 aut |
| 700 | 1 | a Ancu, C.u Grigore T. Popa University of Medicine and Pharmacy4 aut |
| 700 | 1 | a Ong, V. H.u University College London4 aut |
| 700 | 1 | a Farge, D.u Paris Diderot University,Saint-Louis Hospital, Paris4 aut |
| 700 | 1 | a Hudson, M.u Jewish General Hospital,McGill University,University of Leeds,Leeds Teaching Hospitals NHS Trust4 aut |
| 700 | 1 | a Matucci-Cerinic, M.u University of Florence4 aut |
| 700 | 1 | a Balbir-Gurman, A.u Technion - Israel Institute of Technology4 aut |
| 700 | 1 | a Midtvedt, O.4 aut |
| 700 | 1 | a Jobanputra, P.u New Queen Elizabeth Hospital4 aut |
| 700 | 1 | a Jordan, A. C.u New Queen Elizabeth Hospital,Nantes University Hospital,University of Nantes4 aut |
| 700 | 1 | a Stevens, W.u St. Vincent's Hospital, Melbourne4 aut |
| 700 | 1 | a Moinzadeh, P.u University of Cologne,University of Adelaide,Royal Adelaide Hospital4 aut |
| 700 | 1 | a Hall, F. C.u University of Cambridge4 aut |
| 700 | 1 | a Agard, C.4 aut |
| 700 | 1 | a Anderson, M. E.u Aintree University Hospital,University of Liverpool4 aut |
| 700 | 1 | a Diot, E.u Hopital Bretonneau4 aut |
| 700 | 1 | a Madhok, R.u Glasgow Royal Infirmary4 aut |
| 700 | 1 | a Akil, M.u Sheffield Teaching Hospitals4 aut |
| 700 | 1 | a Buch, M. H.4 aut |
| 700 | 1 | a Chung, L.u Stanford University4 aut |
| 700 | 1 | a Damjanov, N. S.u University of Belgrade4 aut |
| 700 | 1 | a Gunawardena, H.u North Bristol NHS Trust4 aut |
| 700 | 1 | a Lanyon, P.u Nottingham University Hospitals NHS Trust4 aut |
| 700 | 1 | a Ahmad, Y.u Peter Maddison Rheumatology Centre4 aut |
| 700 | 1 | a Chakravarty, K.u Queen’s Hospital4 aut |
| 700 | 1 | a Jacobsen, S.u Copenhagen University Hospital,University of Copenhagen4 aut |
| 700 | 1 | a MacGregor, A. J.u University of East Anglia4 aut |
| 700 | 1 | a McHugh, N.u Royal National Hospital for Rheumatic Diseases4 aut |
| 700 | 1 | a Müller-Ladner, U.u Justus Liebig University Giessen4 aut |
| 700 | 1 | a Riemekasten, G.u University of Lübeck4 aut |
| 700 | 1 | a Becker, M.u Charité - University Medicine Berlin4 aut |
| 700 | 1 | a Roddy, J.u Royal Perth Hospital4 aut |
| 700 | 1 | a Carreira, P. E.u 12 de Octubre University Hospital4 aut |
| 700 | 1 | a Fauchais, A. L.u University Hospital Of Limoges4 aut |
| 700 | 1 | a Hachulla, E.u University of Lille4 aut |
| 700 | 1 | a Hamilton, J.4 aut |
| 700 | 1 | a Inanç, M.u Istanbul University4 aut |
| 700 | 1 | a McLaren, J. S.u Whyteman's Brae Hospital,Monash University4 aut |
| 700 | 1 | a Van Laar, J. M.4 aut |
| 700 | 1 | a Pathare, S.u James Cook University Hospital4 aut |
| 700 | 1 | a Proudman, S. M.4 aut |
| 700 | 1 | a Rudin, Anna,d 1961u University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research4 aut0 (Swepub:gu)xrudan |
| 700 | 1 | a Sahhar, J.4 aut |
| 700 | 1 | a Coppere, B.u Hôpital Edouard Herriot4 aut |
| 700 | 1 | a Serratrice, C.u Hospital Saint Joseph4 aut |
| 700 | 1 | a Sheeran, T.u Cannock Chase Hospital4 aut |
| 700 | 1 | a Veale, D. J.u St Vincent's University Hospital4 aut |
| 700 | 1 | a Grange, C.u Centre Hospitalier Lyon Sud4 aut |
| 700 | 1 | a Trad, G. S.u CHU Ambroise Paré4 aut |
| 700 | 1 | a Denton, C. P.u University College London4 aut |
| 700 | 1 | a Midtvedt, Øyvindu Oslo university hospital4 aut |
| 710 | 2 | a University of Manchesterb Christie NHS Foundation Trust4 org |
| 773 | 0 | t Annals of the Rheumatic Diseasesd : BMJg 77:4, s. 563-570q 77:4<563-570x 0003-4967x 1468-2060 |
| 856 | 4 | u https://ard.bmj.com/content/annrheumdis/77/4/563.full.pdf |
| 856 | 4 | u http://dx.doi.org/10.1136/annrheumdis-2017-211912x freey FULLTEXT |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/266334 |
| 856 | 4 8 | u https://doi.org/10.1136/annrheumdis-2017-211912 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/b5af0956-5f33-464b-a969-bead190d3d1b |
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- Herrick, A. L.
- Peytrignet, S.
- Lunt, M.
- Pan, X.
- Hesselstrand, Ro ...
- Mouthon, L.
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- Silman, A. J.
- Dinsdale, G.
- Brown, E.
- Czirják, L.
- Distler, J. H. W ...
- Distler, O.
- Fligelstone, K.
- Gregory, W. J.
- Ochiel, R.
- Vonk, M. C.
- Ancu, C.
- Ong, V. H.
- Farge, D.
- Hudson, M.
- Matucci-Cerinic, ...
- Balbir-Gurman, A ...
- Midtvedt, O.
- Jobanputra, P.
- Jordan, A. C.
- Stevens, W.
- Moinzadeh, P.
- Hall, F. C.
- Agard, C.
- Anderson, M. E.
- Diot, E.
- Madhok, R.
- Akil, M.
- Buch, M. H.
- Chung, L.
- Damjanov, N. S.
- Gunawardena, H.
- Lanyon, P.
- Ahmad, Y.
- Chakravarty, K.
- Jacobsen, S.
- MacGregor, A. J.
- McHugh, N.
- Müller-Ladner, U ...
- Riemekasten, G.
- Becker, M.
- Roddy, J.
- Carreira, P. E.
- Fauchais, A. L.
- Hachulla, E.
- Hamilton, J.
- Inanç, M.
- McLaren, J. S.
- Van Laar, J. M.
- Pathare, S.
- Proudman, S. M.
- Rudin, Anna, 196 ...
- Sahhar, J.
- Coppere, B.
- Serratrice, C.
- Sheeran, T.
- Veale, D. J.
- Grange, C.
- Trad, G. S.
- Denton, C. P.
- Midtvedt, Øyvind
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