WFRF:(Meadows Jennifer R.S.)
Search: WFRF:(Meadows Jennifer R.S.) > (2010-2014) > The same ELA class ...
- 2 of 6
- Previous record
- Next record
- To hitlist
The same ELA class II risk factors confer equine insect bite hypersensitivity in two distinct populations
-
- Andersson, Lisa (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics
- Swinbune, June E. (author)
-
- Meadows, Jennifer R. S. (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
- show more...
- Brostrom, Hans (author)
- Frey, Rebecka (author)
- Sundquist, Marie (author)
- Tseng, Chia T. (author)
- show less...
- (creator_code:org_t)
- 2011-09-23
- 2012
- English.
- In: Immunogenetics. - : Springer Science and Business Media LLC. - 0093-7711 .- 1432-1211. ; 64:3, s. 201-208
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Insect bite hypersensitivity (IBH) is a chronic allergic dermatitis common in horses. Affected horses mainly react against antigens present in the saliva from the biting midges, Culicoides ssp, and occasionally black flies, Simulium ssp. Because of this insect dependency, the disease is clearly seasonal and prevalence varies between geographical locations. For two distinct horse breeds, we genotyped four microsatellite markers positioned within the MHC class II region and sequenced the highly polymorphic exons two from DRA and DRB3, respectively. Initially, 94 IBH-affected and 93 unaffected Swedish born Icelandic horses were tested for genetic association. These horses had previously been genotyped on the Illumina Equine SNP50 BeadChip, which made it possible to ensure that our study did not suffer from the effects of stratification. The second population consisted of 106 unaffected and 80 IBH-affected Exmoor ponies. We show that variants in the MHC class II region are associated with disease susceptibility (p(raw)=2.34x10(-5)), with the same allele (COR112:274) associated in two separate populations. In addition, we combined microsatellite and sequencing data in order to investigate the pattern of homozygosity and show that homozygosity across the entire MHC class II region is associated with a higher risk of developing IBH (p=0.0013). To our knowledge this is the first time in any atopic dermatitis suffering species, including man, where the same risk allele has been identified in two distinct populations.
Subject headings
- LANTBRUKSVETENSKAPER -- Husdjursvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Animal and Dairy Sience (hsv//eng)
- LANTBRUKSVETENSKAPER -- Veterinärmedicin (hsv//swe)
- AGRICULTURAL SCIENCES -- Veterinary Science (hsv//eng)
Keyword
- Insect bite hypersensitivity
- Summer eczema
- ELA
- MHC
- Horse
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Immunogenetics (Search for host publication in LIBRIS)
To the university's database
- 2 of 6
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Andersson, Lisa
- Swinbune, June E ...
- Meadows, Jennife ...
- Brostrom, Hans
- Eriksson, Susann ...
- Fikse, Freddy
- show more...
- Frey, Rebecka
- Sundquist, Marie
- Tseng, Chia T.
- Mikko, Sofia
- Lindgren, Gabrie ...
- show less...
- About the subject
-
- AGRICULTURAL SCIENCES
- AGRICULTURAL SCI ...
- and Animal and Dairy ...
-
- AGRICULTURAL SCIENCES
- AGRICULTURAL SCI ...
- and Veterinary Scien ...
- Articles in the publication
- Immunogenetics
- By the university
- Uppsala University
- Swedish University of Agricultural Sciences
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
