SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Morelli Luca)
 

Search: WFRF:(Morelli Luca) > (2020-2023) > Mitochondrial DNA C...

Mitochondrial DNA Copy-Number Variation and Pancreatic Cancer Risk in the Prospective EPIC Cohort

Gentiluomo, Manuel (author)
Katzke, Verena A. (author)
Kaaks, Rudolf (author)
show more...
Tjonneland, Anne (author)
Severi, Gianluca (author)
Perduca, Vittorio (author)
Boutron-Ruault, Marie-Christine (author)
Weiderpass, Elisabete (author)
Ferrari, Pietro (author)
Johnson, Theron (author)
Schulze, Matthias B. (author)
Bergmann, Manuela (author)
Trichopoulou, Antonia (author)
Karakatsani, Anna (author)
La Vecchia, Carlo (author)
Palli, Domenico (author)
Grioni, Sara (author)
Panico, Salvatore (author)
Tumino, Rosario (author)
Sacerdote, Carlotta (author)
Bueno-de-Mesquita, Bas (author)
Vermeulen, Roel (author)
Sandanger, Torkjel M. (author)
Quiros, J. Ramon (author)
Rodriguez-Barranco, Miguel (author)
Amiano, Pilar (author)
Colorado-Yohar, Sandra (author)
Ardanaz, Eva (author)
Sund, Malin (author)
Umeå universitet,Kirurgi
Khaw, Kay-Tee (author)
Wareham, Nicholas J. (author)
Schmidt, Julie A. (author)
Jakszyn, Paula (author)
Morelli, Luca (author)
Canzian, Federico (author)
Campa, Daniele (author)
show less...
 (creator_code:org_t)
Philadelphia : American Association for Cancer Research, 2020
2020
English.
In: Cancer Epidemiology, Biomarkers and Prevention. - Philadelphia : American Association for Cancer Research. - 1055-9965 .- 1538-7755. ; 29:3, s. 681-686
Related links:
https://urn.kb.se/re...
show more...
https://doi.org/10.1...
show less...
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Background: Mitochondrial DNA (mtDNA) copy number in peripheral blood has been found to be sociated with risk of developing several cancers. However, data on pancreatic ductal adenocarcinoma DAC) are very limited.Methods: To further our knowledge on this topic, we measured relative mtDNA copy number by a antitative real-time PCR assay in peripheral leukocyte samples of 476PDACcases and 357 controls sted within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.Results: We observed lower mtDNA copy number with advancing age (P = 6.54 x 10(-5)) and with a high dy mass index (BMI) level (P = 0.004) and no association with sex, smoking behavior, and alcohol nsumption. We found an association between increased mtDNA copy number and decreased risk of veloping PDAC with an odds ratios (OR) of 0.35 [95% confidence interval (CI), 0.160.79; P = 0.01] when mparing the fifth quintile with the first using an unconditional logistic regression and an OR of 0.19 5% CI, 0.07-0.52; P = 0.001) with a conditional analysis. Analyses stratified by BMI showed an sociation between high mtDNA copy number and decreased risk in the stratum of normal weight, nsistent with the main analyses.Conclusions: Our results suggest a protective effect of a higher number of mitochondria, measured in ripheral blood leukocytes, on PDAC risk.Impact: Our findings highlight the importance of understanding the mitochondrial biology in pancreatic ncer.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view