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Sökning: WFRF:(Mosolits Szilvia) > Induction of IgM, I...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003334naa a2200481 4500
001oai:DiVA.org:uu-178073
003SwePub
008120727s2012 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:124880948
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1780732 URI
0247 a https://doi.org/10.1007/s10875-012-9662-72 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1248809482 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Staff, Carolineu Karolinska Institutet4 aut
2451 0a Induction of IgM, IgA and IgE Antibodies in Colorectal Cancer Patients Vaccinated with a Recombinant CEA Protein
264 c 2012-03-02
264 1b Springer Science and Business Media LLC,c 2012
338 a print2 rdacarrier
520 a Previous clinical studies have indicated that natural IgM antibodies have the ability to induce apoptosis of tumor cells but IgE and IgA may also mediate tumor cell killing (in addition to IgG). The aim of the study was to analyse induction of IgM, IgA and IgE antibodies in patients vaccinated with the tumor associated antigen CEA. Twenty-four resected CRC patients without macroscopic disease were immunized seven times with CEA +/- GM-CSF. Four different dose schedules were used over a 12-month period. IgM, IgA and IgE antibody responses against recombinant CEA were determined by ELISA. Patients were monitored immunologically for 36 months and clinically for 147 months. GM-CSF significantly augmented the anti-CEA response for all three antibody classes. Low dose of CEA tended to induce a higher IgM, IgA or IgE anti-CEA antibody response than higher. Anti-CEA IgA antibodies could lyse CEA positive tumor cells in antibody dependent cellular cytotoxicity (ADCC) as well as in complement dependent cytotoxicity (CDC). A significant correlation between survival and high IgA anti-CEA titers was noted (p = 0.02) irrespective of GM-CSF treatment. The observation that IgA anti-CEA antibodies were cytotoxic and associated with improved survival might indicate that also these antibodies may exert a clinical anti-tumor effect.
653 a Colorectal cancer
653 a CEA
653 a GM-CSF
653 a Vaccination
653 a IgA
653 a CDC
653 a ADCC
7001 a Magnusson, Carl G. M.4 aut
7001 a Hojjat-Farsangi, Mohammadu Karolinska Institutet4 aut
7001 a Mosolits, Szilvia4 aut
7001 a Liljefors, Mariau Karolinska Institutet4 aut
7001 a Frödin, Jan-Eriku Karolinska Institutet4 aut
7001 a Wahrén, Brittau Karolinska Institutet4 aut
7001 a Mellstedt, Håkanu Karolinska Institutet4 aut
7001 a Ullenhag, Gustav J.u Uppsala universitet,Enheten för onkologi4 aut0 (Swepub:uu)gustulle
7102 a Karolinska Institutetb Enheten för onkologi4 org
7730 t Journal of Clinical Immunologyd : Springer Science and Business Media LLCg 32:4, s. 855-865q 32:4<855-865x 0271-9142x 1573-2592
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-178073
8564 8u https://doi.org/10.1007/s10875-012-9662-7
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:124880948

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