A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort

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Fältnamn	Indikatorer	Metadata
000		05854naa a2201021 4500
001		oai:lup.lub.lu.se:68e5ee38-bc36-4f42-a894-94ffc11e8174
003		SwePub
008		160401s2011 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:122131480
024	7	a https://lup.lub.lu.se/record/18686822 URI
024	7	a https://doi.org/10.1136/ard.2010.1418382 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1221314802 URI
040		a (SwePub)lud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Bossini-Castillo, Lara4 aut
245	1 0	a A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort
264		c 2010-12-27
264	1	b BMJ,c 2011
520		a Objectives The aim of this study was to confirm the influence of TNFSF4 polymorphisms on systemic sclerosis (SSc) susceptibility and phenotypic features. Methods A total of 8 European populations of Caucasian ancestry were included, comprising 3014 patients with SSc and 3125 healthy controls. Four genetic variants of TNFSF4 gene promoter (rs1234314, rs844644, rs844648 and rs12039904) were selected as genetic markers. Results A pooled analysis revealed the association of rs1234314 and rs12039904 polymorphisms with SSc (OR 1.15, 95% CI 1.02 to 1.31; OR 1.18, 95% CI 1.08 to 1.29, respectively). Significant association of the four tested variants with patients with limited cutaneous SSc (lcSSc) was revealed (rs1234314 OR 1.22, 95% CI 1.07 to 1.38; rs844644 OR 0.91, 95% CI 0.83 to 0.99; rs844648 OR 1.10, 95% CI 1.01 to 1.20 and rs12039904 OR 1.20, 95% CI 1.09 to 1.33). Association of rs1234314, rs844648 and rs12039904 minor alleles with patients positive for anti-centromere antibodies (ACA) remained significant (OR 1.23, 95% CI 1.10 to 1.37; OR 1.12, 95% CI 1.01 to 1.25; OR 1.22, 95% CI 1.07 to 1.38, respectively). Haplotype analysis confirmed a protective haplotype associated with SSc, lcSSc and ACA positive subgroups (OR 0.88, 95% CI 0.82 to 0.96; OR 0.88, 95% CI 0.80 to 0.96; OR 0.86, 95% CI 0.77 to 0.97, respectively) and revealed a new risk haplotype associated with the same groups of patients (OR 1.14, 95% CI 1.03 to 1.26; OR 1.20, 95% CI 1.08 to 1.35; OR 1.23, 95% CI 1.07 to 1.42, respectively). Conclusions The data confirm the influence of TNFSF4 polymorphisms in SSc genetic susceptibility, especially in subsets of patients positive for lcSSc and ACA.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
700	1	a Broen, Jasper C. A.4 aut
700	1	a Simeon, Carmen P.4 aut
700	1	a Beretta, Lorenzo4 aut
700	1	a Vonk, Madelon C.4 aut
700	1	a Ortego-Centeno, Norberto4 aut
700	1	a Espinosa, Gerard4 aut
700	1	a Carreira, Patricia4 aut
700	1	a Teresa Camps, Maria4 aut
700	1	a Navarrete, Nuria4 aut
700	1	a Gonzalez-Escribano, Maria F.4 aut
700	1	a Vicente-Rabaneda, Esther4 aut
700	1	a Rodriguez, Luis4 aut
700	1	a Tolosa, Carlos4 aut
700	1	a Roman-Ivorra, Jose A.4 aut
700	1	a Gomez-Gracia, Inmaculada4 aut
700	1	a Garcia-Hernandez, Francisco J.4 aut
700	1	a Castellvi, Ivan4 aut
700	1	a Gallego, Maria4 aut
700	1	a Fernandez-Nebro, Antonio4 aut
700	1	a Garcia-Portales, Rosa4 aut
700	1	a Victoria Egurbide, Maria4 aut
700	1	a Fonollosa, Vicente4 aut
700	1	a Garcia de la Pena, Paloma4 aut
700	1	a Pros, Ana4 aut
700	1	a Gonzalez-Gay, Miguel A.4 aut
700	1	a Hesselstrand, Rogeru Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)reum-rhe
700	1	a Riemekasten, Gabriela4 aut
700	1	a Witte, Torsten4 aut
700	1	a Coenen, Marieke J. H.4 aut
700	1	a Koeleman, Bobby P.4 aut
700	1	a Houssiau, Frederic4 aut
700	1	a Smith, Vanessa4 aut
700	1	a de Keyser, Filip4 aut
700	1	a Westhovens, Rene4 aut
700	1	a De Langhe, Ellen4 aut
700	1	a Voskuyl, Alexandre E.4 aut
700	1	a Schuerwegh, Annemie J.4 aut
700	1	a Chee, Meng May4 aut
700	1	a Madhok, Rajan4 aut
700	1	a Shiels, Paul4 aut
700	1	a Fonseca, Carmen4 aut
700	1	a Denton, Christopher4 aut
700	1	a Claes, Kathleen4 aut
700	1	a Padykov, Leonidu Karolinska Institutet4 aut
700	1	a Nordin, Annikau Karolinska Institutet4 aut
700	1	a Palm, Oyvind4 aut
700	1	a Lie, Benedicte A.4 aut
700	1	a Airo, Paolo4 aut
700	1	a Scorza, Raffaella4 aut
700	1	a van Laar, Jacob M.4 aut
700	1	a Hunzelmann, Nicolas4 aut
700	1	a Kreuter, Alexander4 aut
700	1	a Herrick, Ariane4 aut
700	1	a Worthington, Jane4 aut
700	1	a Radstake, Timothy R. D. J.4 aut
700	1	a Martin, Javier4 aut
700	1	a Rueda, Blanca4 aut
710	2	a Reumatologi och molekylär skelettbiologib Sektion III4 org
773	0	t Annals of the Rheumatic Diseasesd : BMJg 70:4, s. 638-641q 70:4<638-641x 1468-2060x 0003-4967
856	4	u http://dx.doi.org/10.1136/ard.2010.141838y FULLTEXT
856	4	u http://eprints.gla.ac.uk/54565/1/ID54565.pdf
856	4 8	u https://lup.lub.lu.se/record/1868682
856	4 8	u https://doi.org/10.1136/ard.2010.141838
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:122131480

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Av författaren/redakt...: Bossini-Castillo ...; Broen, Jasper C. ...; Simeon, Carmen P ...; Beretta, Lorenzo; Vonk, Madelon C.; Ortego-Centeno, ...; visa fler...; Espinosa, Gerard; Carreira, Patric ...; Teresa Camps, Ma ...; Navarrete, Nuria; Gonzalez-Escriba ...; Vicente-Rabaneda ...; Rodriguez, Luis; Tolosa, Carlos; Roman-Ivorra, Jo ...; Gomez-Gracia, In ...; Garcia-Hernandez ...; Castellvi, Ivan; Gallego, Maria; Fernandez-Nebro, ...; Garcia-Portales, ...; Victoria Egurbid ...; Fonollosa, Vicen ...; Garcia de la Pen ...; Pros, Ana; Gonzalez-Gay, Mi ...; Hesselstrand, Ro ...; Riemekasten, Gab ...; Witte, Torsten; Coenen, Marieke ...; Koeleman, Bobby ...; Houssiau, Freder ...; Smith, Vanessa; de Keyser, Filip; Westhovens, Rene; De Langhe, Ellen; Voskuyl, Alexand ...; Schuerwegh, Anne ...; Chee, Meng May; Madhok, Rajan; Shiels, Paul; Fonseca, Carmen; Denton, Christop ...; Claes, Kathleen; Padykov, Leonid; Nordin, Annika; Palm, Oyvind; Lie, Benedicte A ...; Airo, Paolo; Scorza, Raffaell ...; van Laar, Jacob ...; Hunzelmann, Nico ...; Kreuter, Alexand ...; Herrick, Ariane; Worthington, Jan ...; Radstake, Timoth ...; Martin, Javier; Rueda, Blanca; visa färre...

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