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Sökning: WFRF:(Newton A. C.) > (2010-2014) > Angiotensin-Convert...

  • Evans, MarieKarolinska Institutet,Karolinska Institute (författare)

Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in Myocardial Infarction Patients With Renal Dysfunction

  • Artikel/kapitelEngelska2016

Förlag, utgivningsår, omfång ...

  • Elsevier BV,2016
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-294665
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-294665URI
  • https://doi.org/10.1016/j.jacc.2016.01.050DOI
  • https://lup.lub.lu.se/record/29021049-96bf-40e6-aa49-e55f4ef3dc0bURI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:133311833URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • BACKGROUND There is no consensus whether angiotensin-converting enzyme inhibitor (ACEI) and angiotensin receptor blocker (ARB) should be used for secondary prevention in all or in only high-risk patients after an acute myocardial infarction (AMI).OBJECTIVES This study sought to investigate whether ACEI/ARB treatment after AMI is associated with better outcomes across different risk profiles, including the entire spectrum of estimated glomerular filtration rates.METHODS This study evaluated discharge and continuous follow-up data on ACEI/ARB use among AMI survivors (2006 to 2009) included in a large Swedish registry. The association between ACEI/ARB treatment and outcomes (mortality, myocardial infarction, stroke, and acute kidney injury [AKI]) was studied using Cox proportional hazards models (intention-to-treat and as treated).RESULTS In total, 45,697 patients (71%) were treated with ACEI/ARB. The 3-year mortality was 19.8% (17.4% of ACEI/ARB users and 25.4% of nonusers). In adjusted analysis, significantly better survival was observed for patients treated with ACEI/ARB (3-year hazard ratio: 0.80; 95% confidence interval: 0.77 to 0.83). The survival benefit was consistent through all kidney function strata, including dialysis patients. Overall, those treated with ACEI/ARB also had lower 3-year risk for myocardial infarction (hazard ratio: 0.91; 95% confidence interval: 0.87 to 0.95), whereas treatment had no significant effect on stroke risk. The crude risk for AKI was in general low (2.5% and 2.0% for treated and nontreated, respectively) and similar across estimated glomerular filtration rate categories but was significantly higher with ACEI/ARB treatment. However, the composite outcome of AKI and mortality favored ACEI/ARB treatment.CONCLUSIONS Treatment with ACEI/ARB after AMI was associated with improved long-term survival, regardless of underlying renal function, and was accompanied by low rates of adverse renal events.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Carrero, Juan-JesusKarolinska Institutet,Karolinska Institute (författare)
  • Szummer, KarolinaKarolinska Institutet,Karolinska Institute (författare)
  • Åkerblom, AxelUppsala University,Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)axeak985 (författare)
  • Edfors, RobertKarolinska Institutet,Karolinska Institute (författare)
  • Spaak, JonasKarolinska Institutet,Karolinska Institute (författare)
  • Jacobson, Stefan H.Karolinska Institutet,Karolinska Institute (författare)
  • Andell, PontusLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-poa (författare)
  • Lindhagen, LarsUppsala University,Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)lla11670 (författare)
  • Jernberg, TomasKarolinska Institutet,Karolinska Institute (författare)
  • Karolinska InstitutetKarolinska Institute (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of the American College of Cardiology: Elsevier BV67:14, s. 1687-16970735-10971558-3597

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