Sökning: WFRF:(Ng Amanda) > Cartography of oppo...
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000 | 07494naa a2201621 4500 | |
001 | oai:DiVA.org:su-183662 | |
003 | SwePub | |
008 | 200726s2020 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1836622 URI |
024 | 7 | a https://doi.org/10.1038/s41591-020-0894-42 DOI |
040 | a (SwePub)su | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Chng, Kern Rei4 aut |
245 | 1 0 | a Cartography of opportunistic pathogens and antibiotic resistance genes in a tertiary hospital environment |
264 | c 2020-06-08 | |
264 | 1 | b Springer Science and Business Media LLC,c 2020 |
338 | a print2 rdacarrier | |
520 | a Although disinfection is key to infection control, the colonization patterns and resistomes of hospital-environment microbes remain underexplored. We report the first extensive genomic characterization of microbiomes, pathogens and antibiotic resistance cassettes in a tertiary-care hospital, from repeated sampling (up to 1.5 years apart) of 179 sites associated with 45 beds. Deep shotgun metagenomics unveiled distinct ecological niches of microbes and antibiotic resistance genes characterized by biofilm-forming and human-microbiome-influenced environments with corresponding patterns of spatiotemporal divergence. Quasi-metagenomics with nanopore sequencing provided thousands of high-contiguity genomes, phage and plasmid sequences (>60% novel), enabling characterization of resistome and mobilome diversity and dynamic architectures in hospital environments. Phylogenetics identified multidrug-resistant strains as being widely distributed and stably colonizing across sites. Comparisons with clinical isolates indicated that such microbes can persist in hospitals for extended periods (>8 years), to opportunistically infect patients. These findings highlight the importance of characterizing antibiotic resistance reservoirs in hospitals and establish the feasibility of systematic surveys to target resources for preventing infections. Spatiotemporal characterization of microbial diversity and antibiotic resistance in a tertiary-care hospital reveals broad distribution and persistence of antibiotic-resistant organisms that could cause opportunistic infections in a healthcare setting. | |
650 | 7 | a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng |
700 | 1 | a Li, Chenhao4 aut |
700 | 1 | a Bertrand, Denis4 aut |
700 | 1 | a Ng, Amanda Hui Qi4 aut |
700 | 1 | a Kwah, Junmei Samantha4 aut |
700 | 1 | a Low, Hwee Meng4 aut |
700 | 1 | a Tong, Chengxuan4 aut |
700 | 1 | a Natrajan, Maanasa4 aut |
700 | 1 | a Zhang, Michael Hongjie4 aut |
700 | 1 | a Xu, Licheng4 aut |
700 | 1 | a Ko, Karrie Kwan Ki4 aut |
700 | 1 | a Ho, Eliza Xin Pei4 aut |
700 | 1 | a Av-Shalom, Tamar4 aut |
700 | 1 | a Teo, Jeanette Woon Pei4 aut |
700 | 1 | a Khor, Chiea Chuen4 aut |
700 | 1 | a Chen, Swaine L.4 aut |
700 | 1 | a Mason, Christopher E.4 aut |
700 | 1 | a Ng, Oon Tek4 aut |
700 | 1 | a Marimuthu, Kalisvar4 aut |
700 | 1 | a Ang, Brenda4 aut |
700 | 1 | a Nagarajan, Niranjan4 aut |
700 | 1 | a Danko, David4 aut |
700 | 1 | a Bezdan, Daniela4 aut |
700 | 1 | a Afshinnekoo, Ebrahim4 aut |
700 | 1 | a Ahsanuddin, Sofia4 aut |
700 | 1 | a Bhattacharya, Chandrima4 aut |
700 | 1 | a Butler, Daniel J.4 aut |
700 | 1 | a De Filippis, Francesca4 aut |
700 | 1 | a Hecht, Jochen4 aut |
700 | 1 | a Kahles, Andre4 aut |
700 | 1 | a Karasikov, Mikhail4 aut |
700 | 1 | a Kyrpides, Nikos C.4 aut |
700 | 1 | a Leung, Marcus H. Y.4 aut |
700 | 1 | a Meleshko, Dmitry4 aut |
700 | 1 | a Mustafa, Harun4 aut |
700 | 1 | a Mutai, Beth4 aut |
700 | 1 | a Neches, Russell Y.4 aut |
700 | 1 | a Ng, Amanda4 aut |
700 | 1 | a Nieto-Caballero, Marina4 aut |
700 | 1 | a Nikolayeva, Olga4 aut |
700 | 1 | a Nikolayeva, Tatyana4 aut |
700 | 1 | a Png, Eileen4 aut |
700 | 1 | a Sanchez, Jorge L.4 aut |
700 | 1 | a Shaaban, Heba4 aut |
700 | 1 | a Sierra, Maria A.4 aut |
700 | 1 | a Tong, Xinzhao4 aut |
700 | 1 | a Young, Ben4 aut |
700 | 1 | a Alicea, Josue4 aut |
700 | 1 | a Bhattacharyya, Malay4 aut |
700 | 1 | a Blekhman, Ran4 aut |
700 | 1 | a Castro-Nallar, Eduardo4 aut |
700 | 1 | a Canas, Ana M.4 aut |
700 | 1 | a Chatziefthimiou, Aspassia D.4 aut |
700 | 1 | a Crawford, Robert W.4 aut |
700 | 1 | a Deng, Youping4 aut |
700 | 1 | a Desnues, Christelle4 aut |
700 | 1 | a Dias-Neto, Emmanuel4 aut |
700 | 1 | a Donnellan, Daisy4 aut |
700 | 1 | a Dybwad, Marius4 aut |
700 | 1 | a Elhaik, Eran4 aut |
700 | 1 | a Ercolini, Danilo4 aut |
700 | 1 | a Frolova, Alina4 aut |
700 | 1 | a Graf, Alexandra B.4 aut |
700 | 1 | a Green, David C.4 aut |
700 | 1 | a Hajirasouliha, Iman4 aut |
700 | 1 | a Hernandez, Mark4 aut |
700 | 1 | a Iraola, Gregorio4 aut |
700 | 1 | a Jang, Soojin4 aut |
700 | 1 | a Jones, Angela4 aut |
700 | 1 | a Kelly, Frank J.4 aut |
700 | 1 | a Knights, Kaymisha4 aut |
700 | 1 | a Labaj, Pawel P.4 aut |
700 | 1 | a Lee, Patrick K. H.4 aut |
700 | 1 | a Shawn, Levy4 aut |
700 | 1 | a Ljungdahl, Peru Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut4 aut0 (Swepub:su)pelju |
700 | 1 | a Lyons, Abigail4 aut |
700 | 1 | a Mason-Buck, Gabriella4 aut |
700 | 1 | a McGrath, Ken4 aut |
700 | 1 | a Mongodin, Emmanuel F.4 aut |
700 | 1 | a Moraes, Milton Ozorio4 aut |
700 | 1 | a Noushmehr, Houtan4 aut |
700 | 1 | a Oliveira, Manuela4 aut |
700 | 1 | a Ossowski, Stephan4 aut |
700 | 1 | a Osuolale, Olayinka O.4 aut |
700 | 1 | a Ozcan, Orhan4 aut |
700 | 1 | a Paez-Espino, David4 aut |
700 | 1 | a Rascovan, Nicolas4 aut |
700 | 1 | a Richard, Hugues4 aut |
700 | 1 | a Raetsch, Gunnar4 aut |
700 | 1 | a Schriml, Lynn M.4 aut |
700 | 1 | a Semmler, Torsten4 aut |
700 | 1 | a Sezerman, Osman U.4 aut |
700 | 1 | a Shi, Leming4 aut |
700 | 1 | a Song, Le Huu4 aut |
700 | 1 | a Suzuki, Haruo4 aut |
700 | 1 | a Court, Denise Syndercombe4 aut |
700 | 1 | a Thomas, Dominique4 aut |
700 | 1 | a Tighe, Scott W.4 aut |
700 | 1 | a Udekwu, Klasu Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut4 aut0 (Swepub:su)kudek |
700 | 1 | a Ugalde, Juan A.4 aut |
700 | 1 | a Valentine, Brandon4 aut |
700 | 1 | a Vassilev, Dimitar4 aut |
700 | 1 | a Vayndorf, Elena4 aut |
700 | 1 | a Velavan, Thirumalaisamy P.4 aut |
700 | 1 | a Zambrano, Maria M.4 aut |
700 | 1 | a Zhu, Jifeng4 aut |
700 | 1 | a Zhu, Sibo4 aut |
700 | 1 | a Mason, Christopher E.4 aut |
710 | 2 | a Stockholms universitetb Institutionen för molekylär biovetenskap, Wenner-Grens institut4 org |
773 | 0 | t Nature Medicined : Springer Science and Business Media LLCg 26, s. 941-951q 26<941-951x 1078-8956x 1546-170X |
856 | 4 | u https://doi.org/10.1038/s41591-020-0894-4y Fulltext |
856 | 4 | u https://www.nature.com/articles/s41591-020-0894-4.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-183662 |
856 | 4 8 | u https://doi.org/10.1038/s41591-020-0894-4 |
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