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  • Appelgren, DanielLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Division of Drug Research, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden,Linkoping Univ, Div Drug Res, Dept Med & Hlth Sci, SE-58185 Linkoping, Sweden (författare)

Neutrophil Extracellular Traps (NETs) in the Cerebrospinal Fluid Samples from Children and Adults with Central Nervous System Infections.

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • 2019-12-23
  • MDPI AG,2020
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-163727
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-163727URI
  • https://doi.org/10.3390/cells9010043DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-80675URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-407647URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding agencies: Region Ostergotland (ALF grants); Swedish Rheumatism Association; Ingrid Asp Foundation; Center for Clinical Research Dalarna; King Gustaf V and Queen Victorias Freemasons Foundations; Aland Cultural Foundation; Wilhelm & Else Stockmann Foundation; German
  • Funding Agencies:Region Östergötland (ALF grants) Ingrid Asp Foundation  Center for Clinical Research Dalarna  King Gustaf V and Queen Victoria's Freemasons Foundations  Åland Cultural Foundation  Wilhelm & Else Stockmann Foundation  German Research Foundation (DFG) GRK1660European Commission (H2020-MSCA-RISE-2015) 690836 PANGVolkswagen90361
  • Neutrophils operate as part of the innate defence in the skin and may eliminate the Borrelia spirochaete via phagocytosis, oxidative bursts, and hydrolytic enzymes. However, their importance in Lyme neuroborreliosis (LNB) is unclear. Neutrophil extracellular trap (NET) formation, which is associated with the production of reactive oxygen species, involves the extrusion of the neutrophil DNA to form traps that incapacitate bacteria and immobilise viruses. Meanwhile, NET formation has recently been studied in pneumococcal meningitis, the role of NETs in other central nervous system (CNS) infections has previously not been studied. Here, cerebrospinal fluid (CSF) samples from clinically well-characterised children (N = 111) and adults (N = 64) with LNB and other CNS infections were analysed for NETs (DNA/myeloperoxidase complexes) and elastase activity. NETs were detected more frequently in the children than the adults (p = 0.01). NET presence was associated with higher CSF levels of CXCL1 (p < 0.001), CXCL6 (p = 0.007), CXCL8 (p = 0.003), CXCL10 (p < 0.001), MMP-9 (p = 0.002), TNF (p = 0.02), IL-6 (p < 0.001), and IL-17A (p = 0.03). NETs were associated with fever (p = 0.002) and correlated with polynuclear pleocytosis (rs = 0.53, p < 0.0001). We show that neutrophil activation and active NET formation occur in the CSF samples of children and adults with CNS infections, mainly caused by Borrelia and neurotropic viruses. The role of NETs in the early phase of viral/bacterial CNS infections warrants further investigation.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Enocsson, HelenaLinköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Division of Neuro and Inflammation Sciences, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden,Linkoping Univ, Div Neuro & Inflammat Sci, Dept Clin & Expt Med, SE-58185 Linkoping, Sweden(Swepub:liu)helen05 (författare)
  • Skogman, Barbro Hedin,1967-Uppsala universitet,Örebro universitet,Institutionen för medicinska vetenskaper,Centrum för klinisk forskning Dalarna,Orebro Univ, Fac Med & Hlth Sci, SE-70281 Orebro, Sweden,Center for Clinical Research Dalarna-Uppsala University, Region Dalarna and Faculty of Medicine and Health Sciences, Örebro University(Swepub:uu)barhe734 (författare)
  • Nordberg, MarikaÅland Central Hospital, Department of Infectious Diseases, AX-22 100 Mariehamn, Åland, Finland,Aland Cent Hosp, Dept Infect Dis, AX-22100 Mariehamn, Aland, Finland (författare)
  • Perander, LindaÅland Central Hospital, Department of Infectious Diseases, AX-22 100 Mariehamn, Åland, Finland,Aland Cent Hosp, Dept Infect Dis, AX-22100 Mariehamn, Aland, Finland (författare)
  • Nyman, DagBimelix AB, AX-22 100 Mariehamn, Åland, Finland (författare)
  • Nyberg, ClaraÅland Central Hospital, Department of Infectious Diseases, AX-22 100 Mariehamn, Åland, Finland,Aland Cent Hosp, Dept Infect Dis, AX-22100 Mariehamn, Aland, Finland (författare)
  • Knopf, JasminDepartment of Internal Medicine 3-Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), DE-91 054 Erlangen, Germany,Friedrich Alexander Univ Erlangen Nurnberg FAU, Dept Internal Med Rheumatol & Immunol 3, Univ Klinikum Erlangen, DE-91054 Erlangen, Germany (författare)
  • Muñoz, Luis EDepartment of Internal Medicine 3-Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), DE-91 054 Erlangen, Germany,Friedrich Alexander Univ Erlangen Nurnberg FAU, Dept Internal Med Rheumatol & Immunol 3, Univ Klinikum Erlangen, DE-91054 Erlangen, Germany (författare)
  • Sjöwall, Christopher,1975-Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland,Division of Neuro and Inflammation Sciences, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden,Linkoping Univ, Div Neuro & Inflammat Sci, Dept Clin & Expt Med, SE-58185 Linkoping, Sweden(Swepub:liu)chrsj93 (författare)
  • Sjöwall, Johanna,1977-Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Infektionskliniken i Östergötland,Clinic of Infectious Diseases, Linköping University Hospital, Linköping, Sweden; Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden,Linkoping Univ Hosp, Clin Infect Dis, SE-58185 Linkoping, Sweden;Linkoping Univ, Dept Clin & Expt Med, SE-58185 Linkoping, Sweden(Swepub:liu)johfo45 (författare)
  • Linköpings universitetAvdelningen för diagnostik och specialistmedicin (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Cells: MDPI AG9:12073-4409

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  • Cells (Sök värdpublikationen i LIBRIS)

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