Efficacy of single dose primaquine with artemisinin combination therapy on P. falciparum gametocytes and transmission: A WWARN individual patient meta-analysis.

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Fältnamn	Indikatorer	Metadata
000		04670naa a2200769 4500
001		oai:DiVA.org:uu-425574
003		SwePub
008		201117s2020 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4255742 URI
024	7	a https://doi.org/10.1093/infdis/jiaa4982 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Stepniewska, Kasia4 aut
245	1 0	a Efficacy of single dose primaquine with artemisinin combination therapy on P. falciparum gametocytes and transmission :b A WWARN individual patient meta-analysis.
264		c 2020-08-11
264	1	b Oxford University Press (OUP),c 2020
338		a electronic2 rdacarrier
520		a BACKGROUND: Since the World Health Organization recommended single low-dose (0.25mg/kg) primaquine (PQ) in combination with artemisinin-based combination therapies (ACTs) in areas of low transmission or artemisinin-resistant P. falciparum, several single-site studies have been conducted to assess its efficacy.METHODS: An individual patient meta-analysis to assess the gametocytocidal and transmission-blocking efficacy of PQ used in combination with different ACTs was conducted. Random effects logistic regression was used to quantify PQ effect on (i) gametocyte carriage in the first two weeks post-treatment; (ii) the probability of infecting at least one mosquito or of a mosquito becoming infected.RESULTS: In 2,574 participants from fourteen studies, PQ reduced PCR-determined gametocyte carriage on days 7 and 14, most apparently in patients presenting with gametocytaemia on day 0 (Odds Ratio (OR)=0.22; 95%CI 0.17-0.28 and OR=0.12; 95%CI 0.08-0.16, respectively). The rate of decline in gametocyte carriage was faster when PQ was combined with artemether-lumefantrine (AL) compared to dihydroartemisinin-piperaquine (DP) (p=0.010 for day 7). Addition of 0.25mg/kg PQ was associated with near complete prevention of transmission to mosquitoes.CONCLUSION: Primaquine's transmission-blocking effects are achieved with 0.25 mg/kg PQ. Gametocyte persistence and infectivity are lower when PQ is combined with AL compared to DP.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
653		a Plasmodium falciparum
653		a Gametocytaemia
653		a Single low dose primaquine
700	1	a Humphreys, Georgina S4 aut
700	1	a Gonçalves, Bronner P4 aut
700	1	a Craig, Elaine4 aut
700	1	a Gosling, Roly4 aut
700	1	a Guerin, Philippe J4 aut
700	1	a Price, Ric N4 aut
700	1	a Barnes, Karen I4 aut
700	1	a Raman, Jaishree4 aut
700	1	a Smit, Menno R4 aut
700	1	a D'Alessandro, Umberto4 aut
700	1	a Stone, Will J R4 aut
700	1	a Bjorkman, Anders4 aut
700	1	a Samuels, Aaron M4 aut
700	1	a Arroyo-Arroyo, Maria I4 aut
700	1	a Bastiaens, Guido J H4 aut
700	1	a Brown, Joelle M4 aut
700	1	a Dicko, Alassane4 aut
700	1	a El-Sayed, Badria B4 aut
700	1	a Elzaki, Salah-Eldin G4 aut
700	1	a Eziefula, Alice C4 aut
700	1	a Kariuki, Simon4 aut
700	1	a Kwambai, Titus K4 aut
700	1	a Maestre, Amanda E4 aut
700	1	a Mårtensson, Andreas,d 1963-u Uppsala universitet,Internationell barnhälsa och nutrition4 aut0 (Swepub:uu)andma331
700	1	a Mosha, Dominic4 aut
700	1	a Mwaiswelo, Richard O4 aut
700	1	a Ngasala, Billy E4 aut
700	1	a Okebe, Joseph4 aut
700	1	a Roh, Michelle E4 aut
700	1	a Sawa, Patrick4 aut
700	1	a Tiono, Alfred B4 aut
700	1	a Chen, Ingrid4 aut
700	1	a Drakeley, Chris J4 aut
700	1	a Bousema, Teun4 aut
710	2	a Uppsala universitetb Internationell barnhälsa och nutrition4 org
773	0	t Journal of Infectious Diseasesd : Oxford University Press (OUP)g 225:7, s. 1215-1226q 225:7<1215-1226x 0022-1899x 1537-6613
856	4	u https://doi.org/10.1093/infdis/jiaa498y Fulltext
856	4	u https://uu.diva-portal.org/smash/get/diva2:1501513/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u https://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiaa498/33880656/jiaa498.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-425574
856	4 8	u https://doi.org/10.1093/infdis/jiaa498

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