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Sökning: WFRF:(Olsen Jørgen H.) > (2015-2019) > Liver diseases in A...

Liver diseases in Adult Life after Childhood Cancer in Scandinavia (ALiCCS) : A population-based cohort study of 32,839 one-year survivors

Bonnesen, Trine Gade (författare)
Aarhus University Hospital
Winther, Jeanette F. (författare)
Danish Cancer Society
Andersen, Klaus K. (författare)
Danish Cancer Society
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Asdahl, Peter H. (författare)
Aarhus University Hospital
de Fine Licht, Sofie (författare)
Danish Cancer Society
Gudmundsdottir, Thorgerdur (författare)
Danish Cancer Society
Sällfors Holmqvist, Anna (författare)
Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
Madanat-Harjuoja, Laura Maria (författare)
Helsinki University Central Hospital,Finnish Cancer Registry
Tryggvadottir, Laufey (författare)
University of Iceland,Icelandic Cancer Registry
Wesenberg, Finn (författare)
Oslo university hospital,University of Oslo,Cancer Registry of Norway, Institute of Population-Based Cancer Research
Heilmann, Carsten (författare)
Copenhagen University Hospital
Olsen, Jørgen H. (författare)
Danish Cancer Society
Hasle, Henrik (författare)
Aarhus University Hospital
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 (creator_code:org_t)
 
2017-11-07
2018
Engelska 7 s.
Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136. ; 142:4, s. 702-708
Relaterad länk:
http://dx.doi.org/10...
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https://onlinelibrar...
https://lup.lub.lu.s...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Information on late onset liver complications after childhood cancer is scarce. To ensure an appropriate follow-up of childhood cancer survivors and reducing late liver complications, the need for comprehensive and accurate information is presented. We evaluate the risk of liver diseases in a large childhood cancer survivor cohort. We included all 1-year survivors of childhood cancer treated in the five Nordic countries. A Cox proportional hazards model was used to estimate hospitalisation rate (hazard) ratios (HRs) for each liver outcome according to type of cancer. We used the risk among survivors of central nervous system tumour as internal reference. With a median follow-up time of 10 years, 659 (2%) survivors had been hospitalised at least once for a liver disease. The risk for hospitalisation for any liver disease was high after hepatic tumour (HR = 6.9) and leukaemia (HR = 1.7). The Danish sub-cohort of leukaemia treated with haematopoietic stem cell transplantation had a substantially higher risk for hospitalisation for all liver diseases combined (HR = 3.8). Viral hepatitis accounted for 286 of 659 hospitalisations corresponding to 43% of all survivors hospitalised for liver disease. The 20-year cumulative risk of viral hepatitis was 1.8% for survivors diagnosed with cancer before 1990 but only 0.3% for those diagnosed after 1990. The risk of liver disease was low but significantly increased among survivors of hepatic tumours and leukaemia. Further studies with focus on the different treatment modalities are needed to further strengthen the prevention of treatment-induced late liver complications.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Gastroenterologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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