Cell swelling precedes seizures induced by inhibition of astrocytic metabolism.

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Fältnamn	Indikatorer	Metadata
000		03821naa a2200397 4500
001		oai:gup.ub.gu.se/84361
003		SwePub
008		240528s2008 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:research.chalmers.se:17a09228-7f96-4ec1-9bbd-84d59010e855
024	7	a https://gup.ub.gu.se/publication/843612 URI
024	7	a https://doi.org/10.1016/j.eplepsyres.2008.03.0122 DOI
024	7	a https://research.chalmers.se/publication/843612 URI
040		a (SwePub)gud (SwePub)cth
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Broberg, Marita,d 1973u Flinders University of South Australia4 aut0 (Swepub:gu)xbrmar
245	1 0	a Cell swelling precedes seizures induced by inhibition of astrocytic metabolism.
264	1	b Elsevier BV,c 2008
520		a It is currently unknown what processes take place at the interface between non-ictal and ictal activity during seizure initiation. In this study, using paralysed awake rats, we focally inhibited astrocytic metabolism with fluorocitrate (FC), causing seizures. We measured changes in electroencephalogram (EEG) (0-300 Hz), and extracellular ion-concentrations during ictal onsets defining possible relationships with impedance-determined cell swelling. In animals showing ictal activity (69%) there were spike-wave discharges, spike-wave discharges followed by spreading depression and spreading depression without any discharges. In a high proportion of spike-wave discharges (>95%), just prior to the first spike-wave discharge, there was a decrease in the volume of the extracellular space. Following the initiation of cell swelling and prior to discharges, there were increases in high-frequency (150-300 Hz) EEG activity, increases in extracellular potassium- and decreases in extracellular calcium-concentrations. We suggest that EEG and ionic changes are not causative of cell swelling. Cell swelling due to metabolic failure in astrocytes at the injected site may release excitatory amino acids. At the same time, our results suggest ion homeostasis is not maintained and increased neuronal excitability and synchronisation occur. These could be the drivers changing normal brain activity into ictal activity.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
650	7	a TEKNIK OCH TEKNOLOGIERx Medicinteknikx Medicinsk laboratorie- och mätteknik0 (SwePub)206012 hsv//swe
650	7	a ENGINEERING AND TECHNOLOGYx Medical Engineeringx Medical Laboratory and Measurements Technologies0 (SwePub)206012 hsv//eng
700	1	a Pope, Kennethu Flinders University of South Australia4 aut
700	1	a Lewis, Tu Flinders University of South Australia4 aut
700	1	a Olsson, Torsten,d 1937u Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)torsten
700	1	a Nilsson, Michael,d 1962u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation,University of Gothenburg4 aut0 (Swepub:gu)xnimic
700	1	a Willoughby, Johnu Flinders University of South Australia4 aut
710	2	a Flinders University of South Australiab Chalmers tekniska högskola4 org
773	0	t Epilepsy Res.d : Elsevier BVg 80:2-3, s. 132-41q 80:2-3<132-41x 0920-1211
856	4	u http://dx.doi.org/10.1016/j.eplepsyres.2008.03.012y FULLTEXT
856	4 8	u https://gup.ub.gu.se/publication/84361
856	4 8	u https://doi.org/10.1016/j.eplepsyres.2008.03.012
856	4 8	u https://research.chalmers.se/publication/84361

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Av författaren/redakt...: Broberg, Marita, ...; Pope, Kenneth; Lewis, T; Olsson, Torsten, ...; Nilsson, Michael ...; Willoughby, John

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Neurologi

TEKNIK OCH TEKNOLOGIER: TEKNIK OCH TEKNO ...; och Medicinteknik; och Medicinsk labora ...

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Av lärosätet: Göteborgs universitet; Chalmers tekniska högskola

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