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Search: WFRF:(Pérez Sala Dolores) > (2020-2023) > Astrocyte dysfuncti...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005320naa a2200433 4500
001oai:lup.lub.lu.se:2d6e326f-e875-4f33-b766-e9952759037f
003SwePub
008230819s2023 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/2d6e326f-e875-4f33-b766-e9952759037f2 URI
0247 a https://doi.org/10.1093/braincomms/fcad1582 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Canals, Isaacu Lund University,Lunds universitet,Stamceller, åldrande och neurodegeneration,Forskargrupper vid Lunds universitet,Glia och nervcellsbiologi,Stem Cells, Aging and Neurodegeneration,Lund University Research Groups,Glial and Neuronal Biology4 aut0 (Swepub:lu)med-ics
2451 0a Astrocyte dysfunction and neuronal network hyperactivity in a CRISPR engineered pluripotent stem cell model of frontotemporal dementia
264 1c 2023
520 a Frontotemporal dementia (FTD) is the second most prevalent type of early-onset dementia and up to 40% of cases are familial forms. One of the genes mutated in patients is CHMP2B, which encodes a protein found in a complex important for maturation of late endosomes, an essential process for recycling membrane proteins through the endolysosomal system. Here, we have generated a CHMP2B-mutated human embryonic stem cell line using genome editing with the purpose to create a human in vitro FTD disease model. To date, most studies have focused on neuronal alterations; however, we present a new co-culture system in which neurons and astrocytes are independently generated from human embryonic stem cells and combined in co-cultures. With this approach, we have identified alterations in the endolysosomal system of FTD astrocytes, a higher capacity of astrocytes to uptake and respond to glutamate, and a neuronal network hyperactivity as well as excessive synchronization. Overall, our data indicates that astrocyte alterations precede neuronal impairments and could potentially trigger neuronal network changes, indicating the important and specific role of astrocytes in disease development.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
7001 a Comella-Bolla, Andreau Lund University,Lunds universitet,Stamceller, åldrande och neurodegeneration,Forskargrupper vid Lunds universitet,Stem Cells, Aging and Neurodegeneration,Lund University Research Groups4 aut0 (Swepub:lu)an6331co
7001 a Cepeda-Prado, Efrainu Lund University,Lunds universitet,Utvecklings- och regenerativ neurobiologi,Forskargrupper vid Lunds universitet,Developmental and Regenerative Neurobiology,Lund University Research Groups4 aut0 (Swepub:lu)ef7187ce
7001 a Avaliani, Nataliau Lund University,Lunds universitet,Experimentell Epilepsi,Forskargrupper vid Lunds universitet,Experimental Epilepsy Group,Lund University Research Groups4 aut0 (Swepub:lu)anal-nia
7001 a Crowe, James Au Lund University,Lunds universitet,Glia och nervcellsbiologi,Forskargrupper vid Lunds universitet,Glial and Neuronal Biology,Lund University Research Groups4 aut0 (Swepub:lu)ja3743cr
7001 a Oburoglu, Lealu Lund University,Lunds universitet,Blodstamcellsutveckling,Forskargrupper vid Lunds universitet,Hematopoietic Stem Cell Development,Lund University Research Groups4 aut0 (Swepub:lu)le3434ob
7001 a Bruzelius, Andreasu Lund University,Lunds universitet,Regenerativ neurofysiologi,Forskargrupper vid Lunds universitet,Regenerative Neurophysiology,Lund University Research Groups4 aut0 (Swepub:lu)an1575br
7001 a King, Naomiu Lund University,Lunds universitet,Beteendevetenskapligt laboratorium,Forskargrupper vid Lunds universitet,Behavioural Neuroscience Laboratory,Lund University Research Groups4 aut0 (Swepub:lu)na5613ki
7001 a Pajares, María Au Biological Research Center (CIB), Madrid4 aut
7001 a Pérez-Sala, Doloresu Biological Research Center (CIB), Madrid4 aut
7001 a Heuer, Andreasu Lund University,Lunds universitet,Beteendevetenskapligt laboratorium,Forskargrupper vid Lunds universitet,Behavioural Neuroscience Laboratory,Lund University Research Groups4 aut0 (Swepub:lu)med-ah4
7001 a Rylander Ottosson, Daniellau Lund University,Lunds universitet,Regenerativ neurofysiologi,Forskargrupper vid Lunds universitet,Regenerative Neurophysiology,Lund University Research Groups4 aut0 (Swepub:lu)med-drr
7001 a Soriano, Jordiu University of Barcelona4 aut
7001 a Ahlenius, Henriku Lund University,Lunds universitet,Stamceller, åldrande och neurodegeneration,Forskargrupper vid Lunds universitet,Stem Cells, Aging and Neurodegeneration,Lund University Research Groups4 aut0 (Swepub:lu)neur-hah
7102 a Stamceller, åldrande och neurodegenerationb Forskargrupper vid Lunds universitet4 org
7730 t Brain Communicationsg 5:3, s. 1-16q 5:3<1-16x 2632-1297
8564 u http://dx.doi.org/10.1093/braincomms/fcad158x freey FULLTEXT
8564 8u https://lup.lub.lu.se/record/2d6e326f-e875-4f33-b766-e9952759037f
8564 8u https://doi.org/10.1093/braincomms/fcad158

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