Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

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MARC

Fältnamn	Indikatorer	Metadata
000		08427naa a2202053 4500
001		oai:lup.lub.lu.se:2491406b-cf62-451a-b8ad-df523798e528
003		SwePub
008		160401s2009 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/13129912 URI
024	7	a https://doi.org/10.1038/ng.2872 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Willer, Cristen J.4 aut
245	1 0	a Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
264		c 2008-12-14
264	1	b Springer Science and Business Media LLC,c 2009
520		a Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide association studies for BMI (n > 32,000) and followed up top signals in 14 additional cohorts (n > 59,000). We strongly confirm FTO and MC4R and identify six additional loci (P < 5 x 10(-8)): TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2 and NEGR1 (where a 45-kb deletion polymorphism is a candidate causal variant). Several of the likely causal genes are highly expressed or known to act in the central nervous system (CNS), emphasizing, as in rare monogenic forms of obesity, the role of the CNS in predisposition to obesity.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng
700	1	a Speliotes, Elizabeth K.4 aut
700	1	a Loos, Ruth J. F.4 aut
700	1	a Li, Shengxu4 aut
700	1	a Lindgren, Cecilia M.4 aut
700	1	a Heid, Iris M.4 aut
700	1	a Berndt, Sonja I.4 aut
700	1	a Elliott, Amanda L.4 aut
700	1	a Jackson, Anne U.4 aut
700	1	a Lamina, Claudia4 aut
700	1	a Lettre, Guillaume4 aut
700	1	a Lim, Noha4 aut
700	1	a Lyon, Helen N.4 aut
700	1	a McCarroll, Steven A.4 aut
700	1	a Papadakis, Konstantinos4 aut
700	1	a Qi, Lu4 aut
700	1	a Randall, Joshua C.4 aut
700	1	a Roccasecca, Rosa Maria4 aut
700	1	a Sanna, Serena4 aut
700	1	a Scheet, Paul4 aut
700	1	a Weedon, Michael N.4 aut
700	1	a Wheeler, Eleanor4 aut
700	1	a Zhao, Jing Hua4 aut
700	1	a Jacobs, Leonie C.4 aut
700	1	a Prokopenko, Inga4 aut
700	1	a Soranzo, Nicole4 aut
700	1	a Tanaka, Toshiko4 aut
700	1	a Timpson, Nicholas J.4 aut
700	1	a Almgren, Peteru Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-pal
700	1	a Bennett, Amanda4 aut
700	1	a Bergman, Richard N.4 aut
700	1	a Bingham, Sheila A.4 aut
700	1	a Bonnycastle, Lori L.4 aut
700	1	a Brown, Morris4 aut
700	1	a Burtt, Noel L. P.4 aut
700	1	a Chines, Peter4 aut
700	1	a Coin, Lachlan4 aut
700	1	a Collins, Francis S.4 aut
700	1	a Connell, John M.4 aut
700	1	a Cooper, Cyrus4 aut
700	1	a Smith, George Davey4 aut
700	1	a Dennison, Elaine M.4 aut
700	1	a Deodhar, Parimal4 aut
700	1	a Elliott, Paul4 aut
700	1	a Erdos, Michael R.4 aut
700	1	a Estrada, Karol4 aut
700	1	a Evans, David M.4 aut
700	1	a Gianniny, Lauren4 aut
700	1	a Gieger, Christian4 aut
700	1	a Gillson, Christopher J.4 aut
700	1	a Guiducci, Candace4 aut
700	1	a Hackett, Rachel4 aut
700	1	a Hadley, David4 aut
700	1	a Hall, Alistair S.4 aut
700	1	a Havulinna, Aki S.4 aut
700	1	a Hebebrand, Johannes4 aut
700	1	a Hofman, Albert4 aut
700	1	a Isomaa, Bo4 aut
700	1	a Jacobs, Kevin B.4 aut
700	1	a Johnson, Toby4 aut
700	1	a Jousilahti, Pekka4 aut
700	1	a Jovanovic, Zorica4 aut
700	1	a Khaw, Kay-Tee4 aut
700	1	a Kraft, Peter4 aut
700	1	a Kuokkanen, Mikko4 aut
700	1	a Kuusisto, Johanna4 aut
700	1	a Laitinen, Jaana4 aut
700	1	a Lakatta, Edward G.4 aut
700	1	a Luan, Jian'an4 aut
700	1	a Luben, Robert N.4 aut
700	1	a Mangino, Massimo4 aut
700	1	a McArdle, Wendy L.4 aut
700	1	a Meitinger, Thomas4 aut
700	1	a Mulas, Antonella4 aut
700	1	a Munroe, Patricia B.4 aut
700	1	a Narisu, Narisu4 aut
700	1	a Ness, Andrew R.4 aut
700	1	a Northstone, Kate4 aut
700	1	a O'Rahilly, Stephen4 aut
700	1	a Purmann, Carolin4 aut
700	1	a Rees, Matthew G.4 aut
700	1	a Ridderstråle, Martinu Lund University,Lunds universitet,Diabetes - klinisk obesitasforskning,Forskargrupper vid Lunds universitet,Diabetes - Clinical Obesity,Lund University Research Groups4 aut0 (Swepub:lu)endo-mri
700	1	a Ring, Susan M.4 aut
700	1	a Rivadeneira, Fernando4 aut
700	1	a Ruokonen, Aimo4 aut
700	1	a Sandhu, Manjinder S.4 aut
700	1	a Saramies, Jouko4 aut
700	1	a Scott, Laura J.4 aut
700	1	a Scuteri, Angelo4 aut
700	1	a Silander, Kaisa4 aut
700	1	a Sims, Matthew A.4 aut
700	1	a Song, Kijoung4 aut
700	1	a Stephens, Jonathan4 aut
700	1	a Stevens, Suzanne4 aut
700	1	a Stringham, Heather M.4 aut
700	1	a Tung, Y. C. Loraine4 aut
700	1	a Valle, Timo T.4 aut
700	1	a Van Duijn, Cornelia M.4 aut
700	1	a Vimaleswaran, Karani S.4 aut
700	1	a Vollenweider, Peter4 aut
700	1	a Waeber, Gerard4 aut
700	1	a Wallace, Chris4 aut
700	1	a Watanabe, Richard M.4 aut
700	1	a Waterworth, Dawn M.4 aut
700	1	a Watkins, Nicholas4 aut
700	1	a Witteman, Jacqueline C. M.4 aut
700	1	a Zeggini, Eleftheria4 aut
700	1	a Zhai, Guangju4 aut
700	1	a Zillikens, M. Carola4 aut
700	1	a Altshuler, David4 aut
700	1	a Caulfield, Mark J.4 aut
700	1	a Chanock, Stephen J.4 aut
700	1	a Farooqi, I. Sadaf4 aut
700	1	a Ferrucci, Luigi4 aut
700	1	a Guralnik, Jack M.4 aut
700	1	a Hattersley, Andrew T.4 aut
700	1	a Hu, Frank B.4 aut
700	1	a Jarvelin, Marjo-Riitta4 aut
700	1	a Laakso, Markku4 aut
700	1	a Mooser, Vincent4 aut
700	1	a Ong, Ken K.4 aut
700	1	a Ouwehand, Willem H.4 aut
700	1	a Salomaa, Veikko4 aut
700	1	a Samani, Nilesh J.4 aut
700	1	a Spector, Timothy D.4 aut
700	1	a Tuomi, Tiinamaija4 aut
700	1	a Tuomilehto, Jaakko4 aut
700	1	a Uda, Manuela4 aut
700	1	a Uitterlinden, Andre G.4 aut
700	1	a Wareham, Nicholas J.4 aut
700	1	a Deloukas, Panagiotis4 aut
700	1	a Frayling, Timothy M.4 aut
700	1	a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr
700	1	a Hayes, Richard B.4 aut
700	1	a Hunter, David J.4 aut
700	1	a Mohlke, Karen L.4 aut
700	1	a Peltonen, Leena4 aut
700	1	a Schlessinger, David4 aut
700	1	a Strachan, David P.4 aut
700	1	a Wichmann, H-Erich4 aut
700	1	a McCarthy, Mark I.4 aut
700	1	a Boehnke, Michael4 aut
700	1	a Barroso, Ines4 aut
700	1	a Abecasis, Goncalo R.4 aut
700	1	a Hirschhorn, Joel N.4 aut
710	2	a Genomik, diabetes och endokrinologib Forskargrupper vid Lunds universitet4 org
773	0	t Nature Geneticsd : Springer Science and Business Media LLCg 41:1, s. 25-34q 41:1<25-34x 1546-1718x 1061-4036
856	4	u http://dx.doi.org/10.1038/ng.287y FULLTEXT
856	4	u https://cdr.lib.unc.edu/downloads/zp38wm65s
856	4 8	u https://lup.lub.lu.se/record/1312991
856	4 8	u https://doi.org/10.1038/ng.287

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By the author/editor: Willer, Cristen ...; Speliotes, Eliza ...; Loos, Ruth J. F.; Li, Shengxu; Lindgren, Cecili ...; Heid, Iris M.; show more...; Berndt, Sonja I.; Elliott, Amanda ...; Jackson, Anne U.; Lamina, Claudia; Lettre, Guillaum ...; Lim, Noha; Lyon, Helen N.; McCarroll, Steve ...; Papadakis, Konst ...; Qi, Lu; Randall, Joshua ...; Roccasecca, Rosa ...; Sanna, Serena; Scheet, Paul; Weedon, Michael ...; Wheeler, Eleanor; Zhao, Jing Hua; Jacobs, Leonie C ...; Prokopenko, Inga; Soranzo, Nicole; Tanaka, Toshiko; Timpson, Nichola ...; Almgren, Peter; Bennett, Amanda; Bergman, Richard ...; Bingham, Sheila ...; Bonnycastle, Lor ...; Brown, Morris; Burtt, Noel L. P ...; Chines, Peter; Coin, Lachlan; Collins, Francis ...; Connell, John M.; Cooper, Cyrus; Smith, George Da ...; Dennison, Elaine ...; Deodhar, Parimal; Elliott, Paul; Erdos, Michael R ...; Estrada, Karol; Evans, David M.; Gianniny, Lauren; Gieger, Christia ...; Gillson, Christo ...; Guiducci, Candac ...; Hackett, Rachel; Hadley, David; Hall, Alistair S ...; Havulinna, Aki S ...; Hebebrand, Johan ...; Hofman, Albert; Isomaa, Bo; Jacobs, Kevin B.; Johnson, Toby; Jousilahti, Pekk ...; Jovanovic, Zoric ...; Khaw, Kay-Tee; Kraft, Peter; Kuokkanen, Mikko; Kuusisto, Johann ...; Laitinen, Jaana; Lakatta, Edward ...; Luan, Jian'an; Luben, Robert N.; Mangino, Massimo; McArdle, Wendy L ...; Meitinger, Thoma ...; Mulas, Antonella; Munroe, Patricia ...; Narisu, Narisu; Ness, Andrew R.; Northstone, Kate; O'Rahilly, Steph ...; Purmann, Carolin; Rees, Matthew G.; Ridderstråle, Ma ...; Ring, Susan M.; Rivadeneira, Fer ...; Ruokonen, Aimo; Sandhu, Manjinde ...; Saramies, Jouko; Scott, Laura J.; Scuteri, Angelo; Silander, Kaisa; Sims, Matthew A.; Song, Kijoung; Stephens, Jonath ...; Stevens, Suzanne; Stringham, Heath ...; Tung, Y. C. Lora ...; Valle, Timo T.; Van Duijn, Corne ...; Vimaleswaran, Ka ...; Vollenweider, Pe ...; Waeber, Gerard; Wallace, Chris; Watanabe, Richar ...; Waterworth, Dawn ...; Watkins, Nichola ...; Witteman, Jacque ...; Zeggini, Elefthe ...; Zhai, Guangju; Zillikens, M. Ca ...; Altshuler, David; Caulfield, Mark ...; Chanock, Stephen ...; Farooqi, I. Sada ...; Ferrucci, Luigi; Guralnik, Jack M ...; Hattersley, Andr ...; Hu, Frank B.; Jarvelin, Marjo- ...; Laakso, Markku; Mooser, Vincent; Ong, Ken K.; Ouwehand, Willem ...; Salomaa, Veikko; Samani, Nilesh J ...; Spector, Timothy ...; Tuomi, Tiinamaij ...; Tuomilehto, Jaak ...; Uda, Manuela; Uitterlinden, An ...; Wareham, Nichola ...; Deloukas, Panagi ...; Frayling, Timoth ...; Groop, Leif; Hayes, Richard B ...; Hunter, David J.; Mohlke, Karen L.; Peltonen, Leena; Schlessinger, Da ...; Strachan, David ...; Wichmann, H-Eric ...; McCarthy, Mark I ...; Boehnke, Michael; Barroso, Ines; Abecasis, Goncal ...; Hirschhorn, Joel ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Nutrition and Di ...

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