Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

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Frazier-Wood, Alexis C.Baylor College of Medicine (author)

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

Article/chapterEnglish2016

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2016-04-18
Nature Research (part of Springer Nature),2016

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LIBRIS-ID:oai:hhs.se:1155162180006056
https://research.hhs.se/esploro/outputs/journalArticle/Genetic-variants-associated-with-subjective-well-being/991001480763206056URI
https://doi.org/10.1038/ng.3552DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:133635855URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype
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Notes

Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (vertical bar(p) over cap vertical bar approximate to 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.

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Furlotte, Nicholas A23andMe (author)
Garfield, VictoriaUniversity College London (GB) (author)
Geisel, Marie HenrikeUniversity Hospital of Essen (author)
Gonzalez, Juan RInstitute for Global Health,Helmholtz Zentrum München-German Research Center for Environmental Health,University of Lausanne (author)
Haitjema, SaskiaUMC Utrecht (author)
Karlsson, RobertKarolinska Institutet,Karolinska Institutet (SE) (author)
Van der Laan, Sander W.UMC Utrecht (author)
Oldehinkel, Albertine J.University of Groningen (NL) (author)
Pasterkamp, GerardUMC Utrecht (author)
Pedersen, Nancy L.Karolinska Institutet,Karolinska Institutet (SE) (author)
Plomin, RobertKing's College London (GB) (author)
Polasek, OzrenUniversity of Split (author)
Power, ChristineSouth Australian Health and Medical Research Institute (author)
Rich, Stephen S.University of Virginia (US) (author)
Ladwig, Karl-HeinzHelmholtz Zentrum München-German Research Center for Environmental Health (author)
Lahti, JariUniversity of Helsinki (FI) (author)
van der Lee, Sven JErasmus Medical Center,University of Minnesota Twin Cities (US) (author)
Lind, Penelope A.QIMR Berghofer Medical Research Institute (author)
Liu, TianMax Planck Institute for Molecular Genetics (author)
Matteson, Lindsay K.University of Minnesota Twin Cities (US) (author)
Mihailov, EvelinBristol University (GB) (author)
Miller, Mike B.University of Minnesota Twin Cities (US),Institute for Research in Extramural Medicine (NL),VU University (NL) (author)
Minica, Camelia CVrije Universiteit Amsterdam (NL) (author)
Nolte, IMUniversity of Groningen (NL),University of Minnesota Twin Cities (US),University of Oxford (GB) (author)
Mook-Kanamori, DennisLeiden University (author)
Most, Peter Johannes Van derUniversity of Groningen (NL) (author)
Oldmeadow, ChristopherHunter Medical Research Institute (author)
Qian, YongNational Institute on Aging (US),University of Queensland (AU) (author)
Raitakari, OlliUniversity of Turku (author)
Rawal, RajeshHelmholtz Zentrum München-German Research Center for Environmental Health,Leiden University,University of Michigan (US),National Institute on Aging (US),University of Edinburgh,Hunter Medical Research Institute (author)
Rosendaal, Frits RLeiden University (author)
Ruijter, Hester M denUMC Utrecht (author)
Schlessinger, DavidNational Institute on Aging (US),Bristol University (GB) (author)
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Smith, Albert VernonIcelandic Heart Association (IS) (author)
Stergiakouli, EvieBristol University (GB) (author)
Tanaka, ToshikoNational Institute on Aging (US),Helmholtz Zentrum München-German Research Center for Environmental Health (author)
Taylor, KentLos Angeles Biomedical Research Institute (author)
Thorleifsson, GudmardeCODE Genetics (author)
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Svento, RauliOulu Business School (author)
Alizadeh, Behrooz ZUniversity of Groningen (NL) (author)
Sørensen, Thorkild I ACopenhagen University (DK) (author)
Spector, Tim DKing's College London (GB) (author)
Starr, John M.University of Edinburgh (author)
Stefansson, KarideCODE Genetics (author)
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Willems, Sara MErasmus Medical Center,Erasmus University (NL) (author)
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Terracciano, AntonioNational Institute on Aging (US) (author)
Thorsteinsdottir, UnnurUniversity of Iceland (author)
Thurik, A. RoyErasmus School of Economics (NL) (author)
Timpson, Nicholas JBristol University (GB) (author)
Tiemeier, HenningErasmus University (NL) (author)
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Vollenweider, PeterUniversity of Lausanne (author)
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Emeny, Rebecca THelmholtz Zentrum München-German Research Center for Environmental Health (author)
Weir, David RUniversity of Michigan (US) (author)
Fatemifar, GhazalehUniversity College London (GB) (author)
Faul, Jessica D.University of Michigan (US) (author)
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Harris, Tamara B.National Institute on Aging (US) (author)
Harris, Juliette MKing's College London (GB) (author)
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Conley, DaltonNew York University (author)
Davey-Smith, GeorgeBristol University (GB) (author)
Holliday, Elizabeth GNewcastle University (author)
Hottenga, Jouke-JanVU University (NL) (author)
De Jager, Philip L.Harvard University (US),National Institute on Aging (US) (author)
Kaakinen, Marika AImperial College (GB) (author)
Kajantie, EeroNational Institute for Health and Welfare,Karolinska Institutet (SE) (author)
Karhunen, VilleUniversity of Oulu (FI) (author)
Kolcic, IvanaUniversity of Split (author)
Kumari, MeenaUniversity of Essex (GB) (author)
Laibson, DavidHarvard University (US) (author)
Medland, Sara E.Queensland Institute of Medical Research (author)
Meyer, Michelle NClarkson University,VU University (NL) (author)
Pickrell, Joseph K.New York Genome Center (author)
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Launer, Lenore J.National Institute on Aging (US) (author)
Franke, LudeUniversity of Groningen (NL) (author)
Li-Gao, RuifangLeiden University (author)
Liewald, David C.University of Edinburgh,Center for Experimental Social Science (author)
Koini, MarisaMedical University of Graz (author)
Loukola, AnuUniversity of Helsinki (FI) (author)
Marques-Vidal, PedroUniversity of Lausanne (author)
Montgomery, Grant WQIMR Berghofer Medical Research Institute (author)
Beauchamp, Jonathan PHarvard University (US) (author)
Koellinger, Philipp D.Erasmus School of Economics (NL) (author)
Benjamin, Daniel J.Cornell University (US) (author)
Mosing, Miriam A.Karolinska Institutet,Karolinska Institutet (SE),Bristol University (GB) (author)
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Pattie, AlisonUniversity of Edinburgh (author)
Petrovic, Katja EMedical University of Graz (author)
Bartels, MeikeInstitute for Research in Extramural Medicine (NL) (author)
Pulkki-Råback, LauraUniversity of Helsinki (FI) (author)
Quaye, LydiaKing's College London (GB) (author)
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Smith, Jennifer A.University of Michigan (US) (author)
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Trzaskowski, MaciejUniversity of Queensland (AU) (author)
Cesarini, DavidCenter for Experimental Social Science (author)
Cox, Simon RUniversity of Edinburgh (author)
Davies, GailUniversity of Edinburgh (author)
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Hofman, AlbertErasmus University (NL) (author)
Vinkhuyzen, Anna A EUniversity of Queensland (AU) (author)
Yu, LeiRush University Medical Center (author)
Zabaneh, DelilahKing's College London (GB) (author)
Attia, John R.Hunter Medical Research Institute (author)
Bennett, David A.Rush University Medical Center (author)
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Bertram, LarsUniversity of Lübeck (author)
Boomsma, Dorret I.VU University (NL) (author)
Snieder, HUniversity of Groningen (NL) (author)
Chang, Shun-ChiaoBrigham and Women's Hospital and Harvard Medical School (author)
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Geus, Eco J C deVU University (NL) (author)
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Baselmans, Bart M. L.VU University (NL) (author)
Groenen, Patrick J. F.Erasmus School of Economics (NL) (author)
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Nivard, Michel M.VU University (NL) (author)
Fontana, Mark AlanUniversity of Southern California (US) (author)
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Karlsson- Linnér, RichardErasmus University (NL) (author)
Rietveld, Cornelius A.Erasmus University (NL) (author)
Derringer, JaimeUniversity of Illinois (US) (author)
Hyppönen, ElinaInstitute of Child Health (GB) (author)
Iacono, William G.University of Minnesota Twin Cities (US) (author)
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Jöckel, Karl-HeinzUniversity Hospital of Essen (author)
Kaprio, JaakkoUniversity of Helsinki (FI) (author)
Kardia, Sharon L RUniversity of Michigan (US) (author)
Keltikangas-Järvinen, LiisaUniversity of Helsinki (FI) (author)
Kraft, PeterHarvard University (US) (author)
Gratten, JacobUniversity of Queensland (AU) (author)
Lee, James J.University of Minnesota Twin Cities (US) (author)
Liu, Jimmy Z.New York Genome Center (author)
de Vlaming, RonaldErasmus School of Economics (NL) (author)
Ahluwalia, Tarunveer SinghCopenhagen University (DK) (author)
Buchwald, JadwigaUniversity of Helsinki (FI) (author)
Cavadino, AlanaQueen Mary University of London (author)
Kubzansky, Laura DHarvard T.H. Chan School of Public Health (author)
Lehtimäki, TerhoUniversity of Tampere (FI) (author)
Magnusson, Patrik K. E.Karolinska Institutet (SE) (author)
Martin, N.G.Queensland Institute of Medical Research (author)
McGue, MattUniversity of Minnesota Twin Cities (US) (author)
Metspalu, AndresUniversity of Tartu (author)
Mills, MelindaUniversity of Oxford (GB) (author)
Mutsert, Renée deLeiden University (author)
Baylor College of Medicine23andMe (creator_code:org_t)

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In:Nature Genetics: Nature Research (part of Springer Nature)48, s. 624-+1061-40361546-1718

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By the author/editor: Frazier-Wood, Al ...; Furlotte, Nichol ...; Garfield, Victor ...; Geisel, Marie He ...; Gonzalez, Juan R; Haitjema, Saskia; show more...; Karlsson, Robert; Van der Laan, Sa ...; Oldehinkel, Albe ...; Pasterkamp, Gera ...; Pedersen, Nancy ...; Plomin, Robert; Polasek, Ozren; Power, Christine; Rich, Stephen S.; Ladwig, Karl-Hei ...; Lahti, Jari; van der Lee, Sve ...; Lind, Penelope A ...; Liu, Tian; Matteson, Lindsa ...; Mihailov, Evelin; Miller, Mike B.; Minica, Camelia ...; Nolte, IM; Mook-Kanamori, D ...; Most, Peter Joha ...; Oldmeadow, Chris ...; Qian, Yong; Raitakari, Olli; Rawal, Rajesh; Rosendaal, Frits ...; Ruijter, Hester ...; Schlessinger, Da ...; Schmidt, Reinhol ...; Realo, Anu; Rueedi, Rico; Schmidt, Börge; Smith, Albert Ve ...; Stergiakouli, Ev ...; Tanaka, Toshiko; Taylor, Kent; Thorleifsson, Gu ...; Schmidt, Helena; Svento, Rauli; Alizadeh, Behroo ...; Sørensen, Thorki ...; Spector, Tim D; Starr, John M.; Stefansson, Kari; Steptoe, Andrew; Wedenoja, Juho; Wellmann, Juerge ...; Westra, Harm-Jan; Willems, Sara M; Zhao, Wei; Amin, Najaf; Bakshi, Andrew; Bergmann, Sven; Terracciano, Ant ...; Thorsteinsdottir ...; Thurik, A. Roy; Timpson, Nichola ...; Tiemeier, Hennin ...; Uitterlinden, An ...; Vollenweider, Pe ...; Wagner, Gert G; Bjornsdottir, Gy ...; Boyle, Patricia ...; Cherney, Samanth ...; Davis, Oliver S. ...; Ding, Jun; Direk, Nese; Eibich, Peter; Emeny, Rebecca T; Weir, David R; Fatemifar, Ghaza ...; Faul, Jessica D.; Ferrucci, Luigi; Forstner, Andrea ...; Gieger, Christia ...; Gupta, Richa; Harris, Tamara B ...; Harris, Juliette ...; Yang, Jian; Conley, Dalton; Davey-Smith, Geo ...; Holliday, Elizab ...; Hottenga, Jouke- ...; De Jager, Philip ...; Kaakinen, Marika ...; Kajantie, Eero; Karhunen, Ville; Kolcic, Ivana; Kumari, Meena; Laibson, David; Medland, Sara E.; Meyer, Michelle ...; Pickrell, Joseph ...; Krueger, Robert ...; Launer, Lenore J ...; Franke, Lude; Li-Gao, Ruifang; Liewald, David C ...; Koini, Marisa; Loukola, Anu; Marques-Vidal, P ...; Montgomery, Gran ...; Beauchamp, Jonat ...; Koellinger, Phil ...; Benjamin, Daniel ...; Mosing, Miriam A ...; Paternoster, Lav ...; Pattie, Alison; Petrovic, Katja ...; Bartels, Meike; Pulkki-Råback, L ...; Quaye, Lydia; Räikkönen, Katri; Rudan, Igor; Scott, Rodney J.; Smith, Jennifer ...; Sutin, Angelina ...; Trzaskowski, Mac ...; Cesarini, David; Cox, Simon R; Davies, Gail; Esko, Tõnu; Hofman, Albert; Vinkhuyzen, Anna ...; Yu, Lei; Zabaneh, Delilah; Attia, John R.; Bennett, David A ...; Berger, Klaus; Bertram, Lars; Boomsma, Dorret ...; Snieder, H; Chang, Shun-Chia ...; Cucca, Francesco; Deary, Ian J.; van Duijn, Corne ...; Eriksson, Johan ...; Bültmann, Ute; Geus, Eco J C de; Johannesson, Mag ...; Okbay, Aysu; Baselmans, Bart ...; Groenen, Patrick ...; Gudnason, Vilmun ...; Hansen, Torben; Hartman, Cathari ...; Haworth, Claire ...; Hayward, Carolin ...; Heath, Andrew C.; Hinds, David A.; De Neve, Jan Emm ...; Turley, Patrick; Nivard, Michel M ...; Fontana, Mark Al ...; Meddens, S. Fleu ...; Karlsson- Linnér ...; Rietveld, Cornel ...; Derringer, Jaime; Hyppönen, Elina; Iacono, William ...; Järvelin, Marjo- ...; Jöckel, Karl-Hei ...; Kaprio, Jaakko; Kardia, Sharon L ...; Keltikangas-Järv ...; Kraft, Peter; Gratten, Jacob; Lee, James J.; Liu, Jimmy Z.; de Vlaming, Rona ...; Ahluwalia, Tarun ...; Buchwald, Jadwig ...; Cavadino, Alana; Kubzansky, Laura ...; Lehtimäki, Terho; Magnusson, Patri ...; Martin, N.G.; McGue, Matt; Metspalu, Andres; Mills, Melinda; Mutsert, Renée d ...; show less...

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