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Lysinibacillus spha...
Lysinibacillus sphaericus mediates stress responses and attenuates arsenic toxicity in Caenorhabditis elegans
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- Mangu, Jagadish Chandra Kumar, 1986- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,The Life Science Centre-Biology, School of Science and Technology, Örebro University, Sweden
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- Rai, Neha (författare)
- The Life Science Centre-Biology, School of Science and Technology, Örebro University, Sweden
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- Mandal, Abul, Professor, 1952- (författare)
- Högskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Bioteknik, Biotechnology,Systems Biology Research Center, School of Bioscience, University of Skövde, Skövde, Sweden
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- Olsson, Per-Erik, 1957- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,The Life Science Centre-Biology, School of Science and Technology, Örebro University, Sweden
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- Jass, Jana, 1963- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,The Life Science Centre-Biology, School of Science and Technology, Örebro University, Sweden
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(creator_code:org_t)
- Elsevier, 2022
- 2022
- Engelska.
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Ingår i: Science of the Total Environment. - : Elsevier. - 0048-9697 .- 1879-1026. ; 835
- Relaterad länk:
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https://doi.org/10.1...
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https://his.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Exposure to toxic metals alters host response and that leads to disease development. Studies have revealed the effects of metals on microbial physiology, however, the role of metal resistant bacteria on host response to metals is unclear. The hypothesis that xenobiotic interactions between gut microbes and arsenic influence the host physiology and toxicity was assessed in a Caenorhabditis elegans model. The arsenic-resistant Lysinibacillus sphaericus B1CDA was fed to C. elegans to determine the host responses to arsenic in comparison to Escherichia coli OP50 food. L. sphaericus diet extended C. elegans lifespan compared to E. coli diet, with an increased expression of genes involved in lifespan, stress response and immunity (hif-1, hsp-16.2, mtl-2, abf-2, clec-60), as well as reduced fat accumulation. Arsenic-exposed worms fed L. sphaericus also had a longer lifespan than those fed E. coli and had an increased expression of genes involved in cytoprotection, stress resistance (mtl-1, mtl-2) and oxidative stress response (cyp-35A2, isp-1, ctl-2, sod-1), together with a decreased accumulation of reactive oxygen species (ROS). In comparison with E. coli, L. sphaericus B1CDA diet increased C. elegans fitness while detoxifying arsenic induced ROS and extending lifespan.
Ämnesord
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- Arsenate
- Arsenite
- C. elegans
- Lifespan
- Lysinibacillus sphaericus
- Reactive oxygen species
- Arsenic
- Genes
- Linearization
- Metals
- Oxygen
- Physiology
- Toxicity
- C elegan
- E. coli
- Elegans
- Host response
- Lifespans
- Lysinibacillus sphericu
- Stresses response
- Escherichia coli
- Bioteknik
- Biotechnology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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