Sökning: WFRF:(Reilly Paul A.) > (2010-2014) > Large-Scale Gene-Ce...
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000 | 09916naa a2202317 4500 | |
001 | oai:lup.lub.lu.se:19739b80-cdd4-4db7-b175-028cfda89d8f | |
003 | SwePub | |
008 | 160401s2012 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/32440002 URI |
024 | 7 | a https://doi.org/10.1016/j.ajhg.2012.08.0322 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Asselbergs, Folkert W.4 aut |
245 | 1 0 | a Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci |
264 | 1 | b Elsevier BV,c 2012 |
520 | a Genome-wide association studies (GWASs) have identified many SNPs underlying variations in plasma-lipid levels. We explore whether additional loci associated with plasma-lipid phenotypes, such as high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TGs), can be identified by a dense gene-centric approach. Our meta-analysis of 32 studies in 66,240 individuals of European ancestry was based on the custom similar to 50,000 SNP genotyping array (the ITMAT-Broad-CARe array) covering similar to 2,000 candidate genes. SNP-lipid associations were replicated either in a cohort comprising an additional 24,736 samples or within the Global Lipid Genetic Consortium. We identified four, six, ten, and four unreported SNPs in established lipid genes for HDL-C, LDL-C, TC, and TGs, respectively. We also identified several lipid-related SNPs in previously unreported genes: DGAT2, HCAR2, GPIHBP1, PPARG, and FTO for HDL-C; SOCS3, APOH, SPTY2D1, BRCA2, and VLDLR for LDL-C; SOCS3, UGT1A1, BRCA2, UBE3B, FCGR2A, CHUK, and INSIG2 for TC; and SERPINF2, C4B, GCK, GATA4, INSR, and LPAL2 for TGs. The proportion of explained phenotypic variance in the subset of studies providing individual-level data was 9.9% for HDL-C, 9.5% for LDL-C, 10.3% for TC, and 8.0% for TGs. This large meta-analysis of lipid phenotypes with the use of a dense gene-centric approach identified multiple SNPs not previously described in established lipid genes and several previously unknown loci. The explained phenotypic variance from this approach was comparable to that from a meta-analysis of GWAS data, suggesting that a focused genotyping approach can further increase the understanding of heritability of plasma lipids. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
700 | 1 | a Guo, Yiran4 aut |
700 | 1 | a van Iperen, Erik P. A.4 aut |
700 | 1 | a Sivapalaratnam, Suthesh4 aut |
700 | 1 | a Tragante, Vinicius4 aut |
700 | 1 | a Lanktree, Matthew B.4 aut |
700 | 1 | a Lange, Leslie A.4 aut |
700 | 1 | a Almoguera, Berta4 aut |
700 | 1 | a Appelman, Yolande E.4 aut |
700 | 1 | a Barnard, John4 aut |
700 | 1 | a Baumert, Jens4 aut |
700 | 1 | a Beitelshees, Amber L.4 aut |
700 | 1 | a Bhangale, Tushar R.4 aut |
700 | 1 | a Chen, Yii-Der Ida4 aut |
700 | 1 | a Gaunt, Tom R.4 aut |
700 | 1 | a Gong, Yan4 aut |
700 | 1 | a Hopewell, Jemma C.4 aut |
700 | 1 | a Johnson, Toby4 aut |
700 | 1 | a Kleber, Marcus E.4 aut |
700 | 1 | a Langaee, Taimour Y.4 aut |
700 | 1 | a Li, Mingyao4 aut |
700 | 1 | a Li, Yun R.4 aut |
700 | 1 | a Liu, Kiang4 aut |
700 | 1 | a McDonough, Caitrin W.4 aut |
700 | 1 | a Meijs, Matthijs El.4 aut |
700 | 1 | a Middelberg, Rita P. S.4 aut |
700 | 1 | a Musunuru, Kiran4 aut |
700 | 1 | a Nelson, Christopher P.4 aut |
700 | 1 | a O'Connell, Jeffery R.4 aut |
700 | 1 | a Padmanabhan, Sandosh4 aut |
700 | 1 | a Pankow, James S.4 aut |
700 | 1 | a Pankratz, Nathan4 aut |
700 | 1 | a Rafelt, Suzanne4 aut |
700 | 1 | a Rajagopalan, Ramakrishnan4 aut |
700 | 1 | a Romaine, Simon P. R.4 aut |
700 | 1 | a Schork, Nicholas J.4 aut |
700 | 1 | a Shaffer, Jonathan4 aut |
700 | 1 | a Shen, Haiqing4 aut |
700 | 1 | a Smith, Erin N.4 aut |
700 | 1 | a Tischfield, Sam E.4 aut |
700 | 1 | a van der Most, Peter J.4 aut |
700 | 1 | a van Vliet-Ostaptchouk, Jana V.4 aut |
700 | 1 | a Verweij, Niek4 aut |
700 | 1 | a Volcik, Kelly A.4 aut |
700 | 1 | a Zhang, Li4 aut |
700 | 1 | a Bailey, Kent R.4 aut |
700 | 1 | a Bailey, Kristian M.4 aut |
700 | 1 | a Bauer, Florianne4 aut |
700 | 1 | a Boer, Jolanda M. A.4 aut |
700 | 1 | a Braund, Peter S.4 aut |
700 | 1 | a Burt, Amber4 aut |
700 | 1 | a Burton, Paul R.4 aut |
700 | 1 | a Buxbaum, Sarah G.4 aut |
700 | 1 | a Chen, Wei4 aut |
700 | 1 | a Cooper-DeHoff, Rhonda M.4 aut |
700 | 1 | a Cupples, L. Adrienne4 aut |
700 | 1 | a deJong, Jonas S.4 aut |
700 | 1 | a Delles, Christian4 aut |
700 | 1 | a Duggan, David4 aut |
700 | 1 | a Fornage, Myriam4 aut |
700 | 1 | a Furlong, Clement E.4 aut |
700 | 1 | a Glazer, Nicole4 aut |
700 | 1 | a Gums, John G.4 aut |
700 | 1 | a Hastie, Claire4 aut |
700 | 1 | a Holmes, Michael V.4 aut |
700 | 1 | a Illig, Thomas4 aut |
700 | 1 | a Kirkland, Susan A.4 aut |
700 | 1 | a Kivimaki, Mika4 aut |
700 | 1 | a Klein, Ronald4 aut |
700 | 1 | a Klein, Barbara E.4 aut |
700 | 1 | a Kooperberg, Charles4 aut |
700 | 1 | a Kottke-Marchant, Kandice4 aut |
700 | 1 | a Kumari, Meena4 aut |
700 | 1 | a LaCroix, Andrea Z.4 aut |
700 | 1 | a Mallela, Laya4 aut |
700 | 1 | a Murugesan, Gurunathan4 aut |
700 | 1 | a Ordovas, Jose4 aut |
700 | 1 | a Ouwehand, Willem H.4 aut |
700 | 1 | a Post, Wendy S.4 aut |
700 | 1 | a Saxena, Richa4 aut |
700 | 1 | a Scharnagl, Hubert4 aut |
700 | 1 | a Schreiner, Pamela J.4 aut |
700 | 1 | a Shah, Tina4 aut |
700 | 1 | a Shields, Denis C.4 aut |
700 | 1 | a Shimbo, Daichi4 aut |
700 | 1 | a Srinivasan, Sathanur R.4 aut |
700 | 1 | a Stolk, Ronald P.4 aut |
700 | 1 | a Swerdlow, Daniel I.4 aut |
700 | 1 | a Taylor Jr, Herman A.4 aut |
700 | 1 | a Topo, Eric J.4 aut |
700 | 1 | a Toskala, Elina4 aut |
700 | 1 | a van Pelt, Joost L.4 aut |
700 | 1 | a van Setten, Jessica4 aut |
700 | 1 | a Yusuf, Salim4 aut |
700 | 1 | a Whittaker, John C.4 aut |
700 | 1 | a Zwinderman, A. H.4 aut |
700 | 1 | a Anand, Sonia S.4 aut |
700 | 1 | a Balmforth, Anthony J.4 aut |
700 | 1 | a Berenson, Gerald S.4 aut |
700 | 1 | a Bezzina, Connie R.4 aut |
700 | 1 | a Boehm, Bernhard O.4 aut |
700 | 1 | a Boerwinkle, Eric4 aut |
700 | 1 | a Casas, Juan P.4 aut |
700 | 1 | a Caulfield, Mark J.4 aut |
700 | 1 | a Clarke, Robert4 aut |
700 | 1 | a Connell, John M.4 aut |
700 | 1 | a Cruickshanks, Karen J.4 aut |
700 | 1 | a Davidson, Karina W.4 aut |
700 | 1 | a Day, Ian N. M.4 aut |
700 | 1 | a de Bakker, Paul I. W.4 aut |
700 | 1 | a Doevendans, Pieter A.4 aut |
700 | 1 | a Dominiczak, Anna E.4 aut |
700 | 1 | a Hall, Alistair S.4 aut |
700 | 1 | a Hartman, Catharina A.4 aut |
700 | 1 | a Hengstenberg, Christian4 aut |
700 | 1 | a Hillege, Hans L.4 aut |
700 | 1 | a Hofker, Marten H.4 aut |
700 | 1 | a Humphries, Steve E.4 aut |
700 | 1 | a Jarvik, Gail P.4 aut |
700 | 1 | a Johnson, Julie A.4 aut |
700 | 1 | a Kaess, Bernhard M.4 aut |
700 | 1 | a Kathiresan, Sekar4 aut |
700 | 1 | a Koenig, Wolfgang4 aut |
700 | 1 | a Lawlor, Debbie A.4 aut |
700 | 1 | a Maerz, Winfried4 aut |
700 | 1 | a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome |
700 | 1 | a Mitchell, Braxton D.4 aut |
700 | 1 | a Montgomery, Grant W.4 aut |
700 | 1 | a Munroe, Patricia B.4 aut |
700 | 1 | a Murray, Sarah S.4 aut |
700 | 1 | a Newhouse, Stephen J.4 aut |
700 | 1 | a Onland-Moret, N. Charlotte4 aut |
700 | 1 | a Poulter, Neil4 aut |
700 | 1 | a Psaty, Bruce4 aut |
700 | 1 | a Redline, Susan4 aut |
700 | 1 | a Rich, Stephen S.4 aut |
700 | 1 | a Rotter, Jerome I.4 aut |
700 | 1 | a Schunkert, Heribert4 aut |
700 | 1 | a Sever, Peter4 aut |
700 | 1 | a Shuldiner, Alan R.4 aut |
700 | 1 | a Silverstein, Roy L.4 aut |
700 | 1 | a Stanton, Alice4 aut |
700 | 1 | a Thorand, Barbara4 aut |
700 | 1 | a Trip, Mieke D.4 aut |
700 | 1 | a Tsai, Michael Y.4 aut |
700 | 1 | a van der Harst, Pim4 aut |
700 | 1 | a van der Schoot, Ellen4 aut |
700 | 1 | a van der Schouw, Yvonne T.4 aut |
700 | 1 | a Verschuren, W. M. Monique4 aut |
700 | 1 | a Watkins, Hugh4 aut |
700 | 1 | a Wilde, Arthur A. M.4 aut |
700 | 1 | a Wolffenbuttel, Bruce H. R.4 aut |
700 | 1 | a Whitfield, John B.4 aut |
700 | 1 | a Hovingh, G. Kees4 aut |
700 | 1 | a Ballantyne, Christie M.4 aut |
700 | 1 | a Wijmenga, Cisca4 aut |
700 | 1 | a Reilly, Muredach P.4 aut |
700 | 1 | a Martin, Nicholas G.4 aut |
700 | 1 | a Wilson, James G.4 aut |
700 | 1 | a Rader, Daniel J.4 aut |
700 | 1 | a Samani, Nilesh J.4 aut |
700 | 1 | a Reiner, Alex P.4 aut |
700 | 1 | a Hegele, Robert A.4 aut |
700 | 1 | a Kastelein, John J. P.4 aut |
700 | 1 | a Hingorani, Aroon D.4 aut |
700 | 1 | a Talmud, Philippa J.4 aut |
700 | 1 | a Hakonarson, Hakon4 aut |
700 | 1 | a Elbers, Clara C.4 aut |
700 | 1 | a Keating, Brendan J.4 aut |
700 | 1 | a Drenos, Fotios4 aut |
710 | 2 | a Kardiovaskulär forskning - hypertonib Forskargrupper vid Lunds universitet4 org |
773 | 0 | t American Journal of Human Geneticsd : Elsevier BVg 91:5, s. 823-838q 91:5<823-838x 0002-9297 |
856 | 4 | u http://dx.doi.org/10.1016/j.ajhg.2012.08.032y FULLTEXT |
856 | 4 | u https://doi.org/10.1016/j.ajhg.2012.08.032 |
856 | 4 8 | u https://lup.lub.lu.se/record/3244000 |
856 | 4 8 | u https://doi.org/10.1016/j.ajhg.2012.08.032 |
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