WFRF:(Robin Angelique)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 14699naa a2201957 4500 | |
| 001 | oai:research.chalmers.se:da6b8b1e-2ec9-4f0a-8cf3-e37a7def8d88 | |
| 003 | SwePub | |
| 008 | 211218s2021 | |||||||||||000 ||eng| | |
| 009 | oai:gup.ub.gu.se/311770 | |
| 024 | 7 | a https://research.chalmers.se/publication/5277612 URI |
| 024 | 7 | a https://doi.org/10.1038/s41586-021-04177-92 DOI |
| 024 | 7 | a https://gup.ub.gu.se/publication/3117702 URI |
| 040 | a (SwePub)cthd (SwePub)gu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Forslund, Sofia K.u European Molecular Biology Laboratory4 aut |
| 245 | 1 0 | a Combinatorial, additive and dose-dependent drug–microbiome associations |
| 264 | c 2021-12-08 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2021 |
| 520 | a During the transition from a healthy state to cardiometabolic disease, patients become heavily medicated, which leads to an increasingly aberrant gut microbiome and serum metabolome, and complicates biomarker discovery1–5. Here, through integrated multi-omics analyses of 2,173 European residents from the MetaCardis cohort, we show that the explanatory power of drugs for the variability in both host and gut microbiome features exceeds that of disease. We quantify inferred effects of single medications, their combinations as well as additive effects, and show that the latter shift the metabolome and microbiome towards a healthier state, exemplified in synergistic reduction in serum atherogenic lipoproteins by statins combined with aspirin, or enrichment of intestinal Roseburia by diuretic agents combined with beta-blockers. Several antibiotics exhibit a quantitative relationship between the number of courses prescribed and progression towards a microbiome state that is associated with the severity of cardiometabolic disease. We also report a relationship between cardiometabolic drug dosage, improvement in clinical markers and microbiome composition, supporting direct drug effects. Taken together, our computational framework and resulting resources enable the disentanglement of the effects of drugs and disease on host and microbiome features in multimedicated individuals. Furthermore, the robust signatures identified using our framework provide new hypotheses for drug–host–microbiome interactions in cardiometabolic disease. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmaceutiska vetenskaper0 (SwePub)301012 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmaceutical Sciences0 (SwePub)301012 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Samhällsfarmaci och klinisk farmaci0 (SwePub)301042 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Social and Clinical Pharmacy0 (SwePub)301042 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
| 653 | a proton pump inhibitors | |
| 653 | a human gut microbiome | |
| 653 | a american-college | |
| 653 | a antibiotic use | |
| 653 | a task-force | |
| 653 | a management | |
| 653 | a guideline | |
| 653 | a alters | |
| 653 | a impact | |
| 653 | a Science & Technology - Other Topics | |
| 700 | 1 | a Chakaroun, Rimau Universität Leipzig,Leipzig University4 aut |
| 700 | 1 | a Zimmermann-Kogadeeva, Mariau European Molecular Biology Laboratory4 aut |
| 700 | 1 | a Markó, Lajosu Max Delbrueck Centrum Fuer Molekulare Medizin,The Max Delbrück Center for Molecular Medicine4 aut |
| 700 | 1 | a Aron-Wisnewsky, Judith4 aut |
| 700 | 1 | a Nielsen, Trineu Köpenhamns universitet,University of Copenhagen4 aut |
| 700 | 1 | a Moitinho-Silva, Lucasu European Molecular Biology Laboratory4 aut |
| 700 | 1 | a Schmidt, Thomas S. B.u European Molecular Biology Laboratory4 aut |
| 700 | 1 | a Falony, Gwenu Katholieke Universiteit Leuven4 aut |
| 700 | 1 | a Vieira-Silva, Sarau Katholieke Universiteit Leuven4 aut |
| 700 | 1 | a Adriouch, Solia4 aut |
| 700 | 1 | a Alves, Renatou European Molecular Biology Laboratory4 aut |
| 700 | 1 | a Assmann, Karen4 aut |
| 700 | 1 | a Bastard, Jean-Phillippeu Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Birkner, Tillu Max Delbrueck Centrum Fuer Molekulare Medizin,The Max Delbrück Center for Molecular Medicine4 aut |
| 700 | 1 | a Caesar, Robert,d 1973u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Center for Cardiovascular and Metabolic Research (CMR),Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xcaero |
| 700 | 1 | a Chilloux, J.u Imperial College of Science, Technology and Medicine4 aut |
| 700 | 1 | a Coelho, Luis P.u European Molecular Biology Laboratory4 aut |
| 700 | 1 | a Fezeu, Leopold4 aut |
| 700 | 1 | a Galleron, Nathalieu Université Paris-Saclay,University Paris-Saclay4 aut |
| 700 | 1 | a Helft, Gerardu Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Isnard, Richardu Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Ji, Boyang,d 1983u Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)bojand |
| 700 | 1 | a Kuhn, Michaelu European Molecular Biology Laboratory4 aut |
| 700 | 1 | a Le Chatelier, Emmanuelleu Université Paris-Saclay,University Paris-Saclay4 aut |
| 700 | 1 | a Myridakis, Antonisu Imperial College of Science, Technology and Medicine4 aut |
| 700 | 1 | a Olsson, Lisa M.,d 1984u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xollit |
| 700 | 1 | a Pons, Nicolasu Université Paris-Saclay,University Paris-Saclay4 aut |
| 700 | 1 | a Prifti, Edi4 aut |
| 700 | 1 | a Quinquis, Benoitu Université Paris-Saclay,University Paris-Saclay4 aut |
| 700 | 1 | a Roume, Hugou Université Paris-Saclay,University Paris-Saclay4 aut |
| 700 | 1 | a Salem, Joe-Elie4 aut |
| 700 | 1 | a Sokolovska, Nataliya4 aut |
| 700 | 1 | a Tremaroli, Valentina,d 1978u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Center for Cardiovascular and Metabolic Research (CMR),Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xtreva |
| 700 | 1 | a Vallès-Colomer, Mireiau Katholieke Universiteit Leuven4 aut |
| 700 | 1 | a Lewinter, Christianu Köpenhamns universitet,University of Copenhagen4 aut |
| 700 | 1 | a Søndertoft, Nadja B.u Köpenhamns universitet,University of Copenhagen4 aut |
| 700 | 1 | a Pedersen, Helle K.u Köpenhamns universitet,University of Copenhagen4 aut |
| 700 | 1 | a Hansen, Tue H.u Köpenhamns universitet,University of Copenhagen4 aut |
| 700 | 1 | a Amouyal, Chloe4 aut |
| 700 | 1 | a Andersson Galijatovic, Ehm Astridu Köpenhamns universitet,University of Copenhagen4 aut |
| 700 | 1 | a Andreelli, Fabrizio4 aut |
| 700 | 1 | a Barthelemy, Olivieru Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Batisse, Jean-Paulu Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Belda, Eugeniu Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Berland, Magalieu Université Paris-Saclay,University Paris-Saclay4 aut |
| 700 | 1 | a Bittar, Randau Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Blottière, Hervéu Université Paris-Saclay,University Paris-Saclay4 aut |
| 700 | 1 | a Bosquet, Fredericu Biobyte Solutions GmbH4 aut |
| 700 | 1 | a Boubrit, Rachidu Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Bourron, Olivieru Biobyte Solutions GmbH4 aut |
| 700 | 1 | a Camus, Mickaelu Université Paris-Saclay,University Paris-Saclay4 aut |
| 700 | 1 | a Cassuto, Dominiqueu Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Ciangura, Cecileu Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Collet, Jean-Philippeu Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Dao, Maria-Carlota4 aut |
| 700 | 1 | a Djebbar, Moradu Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Doré, Angéliqueu Université Paris-Saclay,University Paris-Saclay4 aut |
| 700 | 1 | a Engelbrechtsen, Line4 aut |
| 700 | 1 | a Fellahi, Sorayau Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Fromentin, Sebastienu Université Paris-Saclay,University Paris-Saclay4 aut |
| 700 | 1 | a Galan, Pilaru Imperial College of Science, Technology and Medicine4 aut |
| 700 | 1 | a Gauguier, Dominiqueu McGill University4 aut |
| 700 | 1 | a Giral, Philippeu Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Hartemann, Agnesu Biobyte Solutions GmbH4 aut |
| 700 | 1 | a Hartmann, Boletteu Köpenhamns universitet,University of Copenhagen4 aut |
| 700 | 1 | a Holst, Jens Juulu Köpenhamns universitet,University of Copenhagen4 aut |
| 700 | 1 | a Hornbak, Maleneu Köpenhamns universitet,University of Copenhagen4 aut |
| 700 | 1 | a Hoyles, L.u Nottingham Trent University4 aut |
| 700 | 1 | a Hulot, Jean-Sébastien4 aut |
| 700 | 1 | a Jaqueminet, Sophieu Université Paris-Saclay,University Paris-Saclay4 aut |
| 700 | 1 | a Jørgensen, Niklas Ryeu Biobyte Solutions GmbH4 aut |
| 700 | 1 | a Julienne, Hannau Université Paris-Saclay,University Paris-Saclay4 aut |
| 700 | 1 | a Justesen, Johanneu Köpenhamns universitet,University of Copenhagen4 aut |
| 700 | 1 | a Kammer, Judithu Universität Leipzig,Leipzig University4 aut |
| 700 | 1 | a Krarup, Nikolaju Köpenhamns universitet,University of Copenhagen4 aut |
| 700 | 1 | a Kerneis, Mathieuu Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Khemis, Jeanu Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Kozlowski, Rubyu Imperial College of Science, Technology and Medicine4 aut |
| 700 | 1 | a Lejard, Véroniqueu Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Levenez, Florenceu Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Lucas-Martini, Leau Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Massey, Robinu Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Martinez-Gili, Laura4 aut |
| 700 | 1 | a Maziers, Nicolasu Université Paris-Saclay,University Paris-Saclay4 aut |
| 700 | 1 | a Medina-Stamminger, Jonathanu Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Montalescot, Gillesu Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Moute, Sandrine4 aut |
| 700 | 1 | a Neves, Ana Luisau Imperial College of Science, Technology and Medicine4 aut |
| 700 | 1 | a Olanipekun, Michaelu Imperial College of Science, Technology and Medicine4 aut |
| 700 | 1 | a Le Pavin, Laetitia Paserou Université Paris-Saclay,University Paris-Saclay4 aut |
| 700 | 1 | a Poitou, Christine4 aut |
| 700 | 1 | a Pousset, Francoiseu Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Pouzoulet, Laurenceu Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Rodriguez-Martinez, Andreau Imperial College of Science, Technology and Medicine4 aut |
| 700 | 1 | a Rouault, Christine4 aut |
| 700 | 1 | a Silvain, Johanneu Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Svendstrup, Mathildeu Köpenhamns universitet,University of Copenhagen4 aut |
| 700 | 1 | a Swartz, Timothy4 aut |
| 700 | 1 | a Vanduyvenboden, Thierryu Université Paris-Saclay,University Paris-Saclay4 aut |
| 700 | 1 | a Vatier, Camilleu Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Walther, Stefanieu Universität Leipzig,Leipzig University4 aut |
| 700 | 1 | a Gøtze, Jens P.u Köpenhamns universitet,University of Copenhagen4 aut |
| 700 | 1 | a Køber, Larsu Köpenhamns universitet,University of Copenhagen4 aut |
| 700 | 1 | a Vestergaard, H.u Köpenhamns universitet,University of Copenhagen4 aut |
| 700 | 1 | a Hansen, Torbenu Köpenhamns universitet,University of Copenhagen4 aut |
| 700 | 1 | a Zucker, Jean-Daniel4 aut |
| 700 | 1 | a Hercberg, Serge4 aut |
| 700 | 1 | a Oppert, Jean-Michelu Assistance publique – Hôpitaux de Paris (AP-HP)4 aut |
| 700 | 1 | a Letunic, Ivicau European Molecular Biology Laboratory4 aut |
| 700 | 1 | a Nielsen, Jens B,d 1962u Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)nielsenj |
| 700 | 1 | a Bäckhed, Fredrik,d 1973u Gothenburg University,Göteborgs universitet,Center for Cardiovascular and Metabolic Research (CMR),Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory4 aut0 (Swepub:gu)xbafre |
| 700 | 1 | a Ehrlich, Stanislav Duskou Université Paris-Saclay,University Paris-Saclay4 aut |
| 700 | 1 | a Dumas, Marc-Emmanuelu Imperial College of Science, Technology and Medicine4 aut |
| 700 | 1 | a Raes, Jeroenu Katholieke Universiteit Leuven4 aut |
| 700 | 1 | a Pedersen, O. B.u Köpenhamns universitet,University of Copenhagen4 aut |
| 700 | 1 | a Clement, K.4 aut |
| 700 | 1 | a Stumvoll, M.u Universität Leipzig,Leipzig University4 aut |
| 700 | 1 | a Bork, Peeru European Molecular Biology Laboratory4 aut |
| 710 | 2 | a European Molecular Biology Laboratoryb Universität Leipzig4 org |
| 773 | 0 | t Natured : Springer Science and Business Media LLCg 600:7889, s. 500-505q 600:7889<500-505x 0028-0836x 1476-4687 |
| 856 | 4 | u http://irep.ntu.ac.uk/id/eprint/45119/1/1502891_Hoyles.pdf |
| 856 | 4 8 | u https://research.chalmers.se/publication/527761 |
| 856 | 4 8 | u https://doi.org/10.1038/s41586-021-04177-9 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/311770 |
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