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Sökning: WFRF:(Roos Raymund A C) > Cholinergic neurona...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004335naa a2200433 4500
001oai:lup.lub.lu.se:fd1dc9e3-05ec-4d66-b3b5-dd8c692fcdd6
003SwePub
008160401s2006 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/1609092 URI
0247 a https://doi.org/10.1093/hmg/ddl2522 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Smith, Rubenu Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine4 aut0 (Swepub:lu)mphy-rsm
2451 0a Cholinergic neuronal defect without cell loss in Huntington's disease.
264 c 2006-09-20
264 1b Oxford University Press (OUP),c 2006
520 a Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG-repeat expansion in the huntingtin (IT15) gene. The striatum is one of the regions most affected by neurodegeneration, resulting in the loss of the medium-sized spiny neurons. Traditionally, the large cholinergic striatal interneurons are believed to be spared. Recent studies demonstrate that neuronal dysfunction without cell death also plays an important role in early and mid-stages of the disease. Here, we report that cholinergic transmission is affected in a HD transgenic mouse model (R6/1) and in tissues from HD patients. Stereological analysis shows no loss of cholinergic neurons in the striatum or septum in R6/1 mice. In contrast, the levels of mRNA and protein for vesicular acetylcholine transporter (VAChT) and choline acetyltransferase (ChAT) are decreased in the striatum and cortex, and acetylcholine esterase activity is lowered in the striatum of R6/1 mice already at young ages. Accordingly, VAChT is also reduced in striatal tissue from patients with HD. The decrease of VAChT in the patient samples studied is restricted to the striatum and does not occur in the hippocampus or the spinal cord. The expression and localization of REST/NRSF, a transcriptional regulator for the VAChT and ChAT genes, are not altered in cholinergic neurons. We show that the R6/1 mice exhibit severe deficits in learning and reference memory. Taken together, our data show that the cholinergic system is dysfunctional in R6/1 and HD patients. Consequently, they provide a rationale for testing of pro-cholinergic drugs in this disease.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
7001 a Chung, Hinfan4 aut
7001 a Rundquist, Sara4 aut
7001 a Maat-Schieman, Marion L C4 aut
7001 a Colgan, Lesley4 aut
7001 a Englund, Elisabetu Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)pat-een
7001 a Liu, Yong-Jian4 aut
7001 a Roos, Raymund A C4 aut
7001 a Faull, Richard L M4 aut
7001 a Brundin, Patriku Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine4 aut0 (Swepub:lu)mphy-pbr
7001 a Li, Jia-Yiu Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine4 aut0 (Swepub:lu)mphy-jli
7102 a Institutionen för experimentell medicinsk vetenskapb Medicinska fakulteten4 org
7730 t Human Molecular Geneticsd : Oxford University Press (OUP)g 15:21, s. 3119-3131q 15:21<3119-3131x 0964-6906x 1460-2083
8564 u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16987871&dopt=Abstractx freey FULLTEXT
8564 u http://dx.doi.org/10.1093/hmg/ddl252x freey FULLTEXT
8564 u https://academic.oup.com/hmg/article-pdf/15/21/3119/1735010/ddl252.pdf
8564 8u https://lup.lub.lu.se/record/160909
8564 8u https://doi.org/10.1093/hmg/ddl252

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