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  • Rundqvist, HeleneKarolinska Institutet (author)

Activation of the erythropoietin receptor in human skeletal muscle

  • Article/chapterEnglish2009

Publisher, publication year, extent ...

  • 2009
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:kth-123227
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-123227URI
  • https://doi.org/10.1530/EJE-09-0342DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:119784826URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • QC 20150624
  • Objective: Erythropoietin receptor (EPOR) expression in non-hematological tissues has been shown to be activated by locally produced and/or systemically delivered EPO. Improved oxygen homeostasis, a well-established consequence of EPOR activation, is very important for human skeletal muscle performance. In the present study we investigate whether human skeletal muscle fibers and satellite cells express EPOR and if it is activated by exercise. Design and methods: Ten healthy males performed 65 min of cycle exercise. Biopsies were obtained from the vastus lateralis muscle and femoral arterio-venous differences in EPO concentrations were estimated. Results: The EPOR proteinwas localized in areas corresponding to the sarcolemma and capillaries. Laser dissection identified EPOR mRNA expression in muscle fibers. Also, EPOR mRNA and protein were both detected in human skeletal muscle satellite cells. In the initial part of the exercise bout there was a release of EPO from the exercising leg to the circulation, possibly corresponding to an increased bioavailability of EPO. After exercise, EPOR mRNA and EPOR-associated JAK2 phosphorylation were increased. Conclusions: Interaction with JAK2 is required for EPOR signaling and the increase found in phosphorylation is therefore closely linked to the activation of EPOR. The receptor activation by acute exercise suggests that signaling through EPOR is involved in exercise-induced skeletal muscle adaptation, thus extending the biological role of EPO into the skeletal muscle.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Rullman, EricKarolinska Institutet (author)
  • Sundberg, Carl JohanKarolinska Institutet (author)
  • Fischer, HeleneKarolinska Institutet (author)
  • Eisleithner, KatarinaKarolinska Institutet (author)
  • Ståhlberg, MarcusKarolinska Institutet (author)
  • Sundblad, PatrikKarolinska Institutet(Swepub:kth)u1ugjn16 (author)
  • Jansson, EvaKarolinska Institutet (author)
  • Gustafsson, ThomasKarolinska Institutet (author)
  • Karolinska Institutet (creator_code:org_t)

Related titles

  • In:European Journal of Endocrinology161:3, s. 427-4340804-46431479-683X

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