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Follow-up of low-risk patients with differentiated thyroid carcinoma: a European perspective.

Schlumberger, Martin (author)
Berg, Gertrud, 1944 (author)
Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för onkologi,Institute of Selected Clinical Sciences, Department of Oncology
Cohen, Ohad (author)
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Duntas, Leonidas (author)
Jamar, François (author)
Jarzab, Barbara (author)
Limbert, Eduard (author)
Lind, Peter (author)
Pacini, Furio (author)
Reiners, Christoph (author)
Sánchez Franco, Franco (author)
Toft, Anthony (author)
Wiersinga, Wilmar M (author)
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 (creator_code:org_t)
2004
2004
English.
In: European journal of endocrinology / European Federation of Endocrine Societies. - 0804-4643. ; 150:2, s. 105-12
Related links:
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • OBJECTIVE: Because differentiated (follicular and papillary) thyroid cancer (DTC) may recur years after initial treatment, the follow-up of patients with DTC is long term. However, this population has changed, with more individuals being discovered at an earlier stage of the disease, so that previous follow-up protocols based mostly on data from high-risk patients no longer apply. We sought to develop an improved protocol for the follow-up of low-risk patients with DTC based on the findings of recent studies. METHODS: We analysed recent literature on the follow-up of DTC. RESULTS: Recent large studies have produced three important findings: (i) in patients with low-risk DTC with no evidence of disease up to the 6- to 12-month follow-up, diagnostic whole-body scan adds no information when serum thyroglobulin (Tg) is undetectable and interference from anti-Tg antibodies is absent; (ii) use of recombinant human thyroid-stimulating hormone to aid Tg measurement is effective and provides greater safety, quality-of-life and work productivity than does levothyroxine withdrawal with its attendant hypothyroidism; and (iii) ultrasonography performed by an experienced operator is the most sensitive means of detecting neck recurrences of DTC. CONCLUSIONS: We present a revised follow-up protocol for low-risk patients taking into account the above findings. This protocol should help clinicians enter a new era of monitoring characterized by greater safety, simplicity, convenience and cost savings.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Keyword

Adenocarcinoma
Follicular
blood
diagnosis
secondary
therapy
Carcinoma
Papillary
blood
diagnosis
secondary
Clinical Protocols
standards
Decision Trees
Europe
Follow-Up Studies
Lymphatic Metastasis
Neoplasm Recurrence
Local
blood
ultrasonography
Practice Guidelines
Recombinant Proteins
diagnostic use
Risk
Thyroglobulin
blood
diagnostic use
Thyroid Neoplasms
blood
diagnosis
therapy
Treatment Outcome

Publication and Content Type

ref (subject category)
art (subject category)

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