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Aspirin as secondar...
Aspirin as secondary prevention in colorectal cancer liver metastasis (ASAC trial): study protocol for a multicentre randomized placebo-controlled trial
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- Yaqub, S. (author)
- Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway. shya@ous-hf.no; Institute of Clinical Medicine, University of Oslo, Oslo, Norway,Oslo Univ Hosp, Dept Hepato Pancreato Biliary Surg, Oslo, Norway.;Univ Oslo, Inst Clin Med, Oslo, Norway.
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- Bjornbeth, B. A. (author)
- Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway,Oslo Univ Hosp, Dept Hepato Pancreato Biliary Surg, Oslo, Norway.
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- Angelsen, J. H. (author)
- Department of Acute and Digestive Surgery, Haukeland University Hospital, Bergen, Norway; Departments of Clinical Medicine, University of Bergen, Bergen, Norway,Haukeland Hosp, Dept Acute & Digest Surg, Bergen, Norway.;Univ Bergen, Dept Clin Med, Bergen, Norway.
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- Fristrup, C. W. (author)
- Department of Surgery, Odense University Hospital, Odense C, Denmark,Odense Univ Hosp, Dept Surg, Odense C, Denmark.
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- Gronbech, J. E. (author)
- Department of Gastrointestinal Surgery, St. Olav’s Hospital, Trondheim University Hospital, Trondheim, Norway; Department of Clinical and Molecular Medicine, NTNU, Norwegian University of Science and Technology, Trondheim, Norway,Univ Trondheim Hosp, St Olavs Hosp, Dept Gastrointestinal Surg, Trondheim, Norway.;Norwegian Univ Sci & Technol, Dept Clin & Mol Med, NTNU, Trondheim, Norway.
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- Hemmingsson, Oskar, 1975- (author)
- Umeå universitet,Kirurgi,Department of Surgical and Perioperative Sciences, Umeå University, Umea, Sweden,Umeå Univ, Dept Surg & Perioperat Sci, Umeå, Sweden.
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- Isaksson, Bengt (author)
- Uppsala universitet,Gastrointestinalkirurgi
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- Juel, I. S. (author)
- Department of Gastrointestinal Surgery, St. Olav’s Hospital, Trondheim University Hospital, Trondheim, Norway,Univ Trondheim Hosp, St Olavs Hosp, Dept Gastrointestinal Surg, Trondheim, Norway.
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- Larsen, P. N. (author)
- Department of Gastrointestinal Surgery, Rigshospitalet, Copenhagen, Denmark,Rigshosp, Dept Gastrointestinal Surg, Copenhagen, Denmark.
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- Lindell, G. (author)
- Department of Surgery, Skåne University Hospital, Lund, Sweden,Skane Univ Hosp, Dept Surg, Lund, Sweden.
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- Mortensen, F. V. (author)
- Department of Surgery, Aarhus University Hospital, Aarhus N, Denmark,Aarhus Univ Hosp, Dept Surg, Aarhus N, Denmark.
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- Mortensen, K. E. (author)
- Department of Gastrointestinal Surgery, University Hospital of North, Tromsø, Norway,Univ Hosp North, Dept Gastrointestinal Surg, Tromso, Norway.
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- Rizell, Magnus, 1963 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery,Department of Transplantation, Institute of Clinical Sciences, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden,Univ Gothenburg, Sahlgrenska Univ Hosp, Inst Clin Sci, Dept Transplantat, Gothenburg, Sweden.
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- Sandström, Per A, 1965- (author)
- Linköpings universitet,Medicinska fakulteten,Avdelningen för kirurgi, ortopedi och onkologi,Region Östergötland, Kirurgiska kliniken US,Cty Council Ostergotland, Dept Surg, Linköping, Sweden.;Div Surg, Dept Biomed & Clin Sci Orthoped & Oncol, Linköping, Sweden.
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- Sandvik, O. M. (author)
- Department of Gastrointestinal Surgery, Stavanger University Hospital, Stavanger, Norway,Stavanger Univ Hosp, Dept Gastrointestinal Surg, Stavanger, Norway.
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- Sparrelid, E. (author)
- Karolinska Institutet
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- Taflin, Helena (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery,Department of Surgery, Institute of Clinical Sciences, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden,Univ Gothenburg, Sahlgrenska Univ Hosp, Inst Clin Sci, Dept Surg, Gothenburg, Sweden.
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- Tasken, K. (author)
- Institute for Cancer Research, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, Oslo, Norway,Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway,Oslo Univ Hosp, Inst Canc Res, Oslo, Norway.;Univ Oslo, Inst Clin Med, Oslo, Norway.
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- Brudvik, Kristoffer W. (author)
- Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway
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- Fretland, Åsmund A. (author)
- Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway
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- Horn, Arild (author)
- Department of Acute and Digestive Surgery, Haukeland University Hospital, Bergen, Norway; Departments of Clinical Medicine, University of Bergen, Bergen, Norway
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- Kleive, Dyre (author)
- Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway
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- Labori, Knut J. (author)
- Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway
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- Søreide, Jon A. (author)
- Department of Gastrointestinal Surgery, Stavanger University Hospital, Stavanger, Norway
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- Tholfsen, Tore (author)
- Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway
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- Villanger, Olaug (author)
- Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway
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- Waage, Anne (author)
- Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway
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Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway shya@ous-hf.no; Institute of Clinical Medicine, University of Oslo, Oslo, Norway Oslo Univ Hosp, Dept Hepato Pancreato Biliary Surg, Oslo, Norway.;Univ Oslo, Inst Clin Med, Oslo, Norway. (creator_code:org_t)
- 2021-09-20
- 2021
- English.
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In: Trials. - London, United Kingdom : Springer Science and Business Media LLC. - 1745-6215. ; 22:1
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Background Colorectal cancer is one the most common cancers in the western world with increasing incidence. Approximately 50% of the patients develop liver metastases. Resection of liver metastases is the treatment of choice although almost half of the resected patients get recurrence in the liver. Methods The ASAC trial is a Scandinavian, multicentre, double-blinded, randomized, placebo-controlled study to determine whether adjuvant treatment with low-dose aspirin (acetylsalicylic acid (ASA)) can improve disease-free survival in patients treated for colorectal cancer liver metastases (CRCLM). Up to 800 patients operated for CRCLM will be randomized to Arm#1 ASA 160 mg once daily or Arm#2 Placebo, for a period of 3 years or until disease recurrence. The patients will be recruited at all major hepatobiliary surgical units in Norway, Sweden and Denmark and have follow-up according to standard of care and the National Guidelines. Discussion The ASAC trial will be the first clinical interventional trial to assess the potential beneficial role of ASA in recurrence of CRCLM and survival. ASA is an inexpensive, well-tolerated and easily accessible drug that will be highly potential as adjuvant drug in secondary prevention of CRCLM if the study shows a beneficial effect. We will also determine the effect of ASA as adjuvant treatment on Health-Related Quality of Life and the cost-effectiveness.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- Colorectal cancer
- Liver metastases
- Aspirin
- Acetylsalicylic acid
- Secondary prevention
- regulatory t-cells
- antitumor immune-responses
- pik3ca mutation
- follow-up
- cyclooxygenase-2
- suppression
- inhibition
- mortality
- diagnosis
- adenomas
- Research & Experimental Medicine
- Acetylsalicylic acid
Publication and Content Type
- ref (subject category)
- art (subject category)
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Trials
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To the university's database
- By the author/editor
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Yaqub, S.
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Bjornbeth, B. A.
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Angelsen, J. H.
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Fristrup, C. W.
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Gronbech, J. E.
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Hemmingsson, Osk ...
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show more...
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Isaksson, Bengt
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Juel, I. S.
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Larsen, P. N.
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Lindell, G.
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Mortensen, F. V.
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Mortensen, K. E.
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Rizell, Magnus, ...
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Sandström, Per A ...
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Sandvik, O. M.
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Sparrelid, E.
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Taflin, Helena
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Tasken, K.
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Brudvik, Kristof ...
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Fretland, Åsmund ...
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Horn, Arild
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Kleive, Dyre
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Labori, Knut J.
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Søreide, Jon A.
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Tholfsen, Tore
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Villanger, Olaug
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Waage, Anne
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
- Articles in the publication
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Trials
- By the university
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University of Gothenburg
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Umeå University
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Linköping University
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Uppsala University
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Karolinska Institutet