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Ovarian epithelial ...
Ovarian epithelial neoplasia after hormonal infertility treatment: long-term follow-up of a historical cohort in Sweden
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- Sanner, Karin, 1961- (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Klinisk och experimentell reproduktionsbiologi/Olovsson
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- Conner, Peter (författare)
- Dept of Obstetrics and Gynecology, Karolinska University Hospital, Stockholm, Sweden
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- Bergfeldt, Kjell (författare)
- Karolinska Institutet
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- Dickman, Paul (författare)
- Karolinska Institutet
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- Sundfeldt, Karin, 1962 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,University of Gothenburg
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- Bergh, Torbjörn (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Klinisk och experimentell reproduktionsbiologi/Olovsson
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- Hagenfeldt, Kerstin (författare)
- Karolinska Institutet
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- Janson, Per-Olof, 1940 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,University of Gothenburg
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Nilsson, Staffan, 1956 (författare)
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- Persson, Ingemar (författare)
- Dept of Medical Epi and Bio, Karolinska Institute, Stockholm, Sweden
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(creator_code:org_t)
- Elsevier BV, 2009
- 2009
- Engelska.
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Ingår i: Fertil Steril. - : Elsevier BV. ; 91:4, s. 1152-1158
- Relaterad länk:
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https://gup.ub.gu.se...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://research.cha...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: To study the association between hormonal infertility treatment and ovarian neoplasia. DESIGN: Historical cohort study. SETTING: Three university hospitals in Sweden. PATIENT(S): A total of 2,768 women assessed and treated for infertility and infertility-associated disorders between 1961 and 1975. INTERVENTION(S): Exposed women received clomiphene citrate and/or gonadotropins. MAIN OUTCOME MEASURE(S): Incidence of ovarian neoplasia. RESULT(S): No overall excess risk of invasive ovarian cancer emerged compared with the general population. In women with gonadotropin treatment for non-ovulatory disorders, the risk was elevated (standardized incidence ratio [SIR] = 5.89; 95% confidence interval [CI] 1.91-13.75); four of the five cases reported hCG treatment only, rendering the biological plausibility uncertain. Multivariate analysis within the cohort indicated that treatment with gonadotropins only was associated with an increased risk of invasive cancer (relative risk = 5.28; 95% CI 1.70-16.47). For borderline tumors, a more than threefold overall increase of tumors (SIR = 3.61; 95% CI 1.45-7.44) was noted; women exposed to clomiphene because of ovulatory disorders showed the highest risk (SIR = 7.47; 95% CI 1.54-21.83). CONCLUSION(S): Our findings of increased risk of ovarian cancer after gonadotropins and of borderline tumors after clomiphene treatment need to be interpreted with caution. However, concern is raised, and further research on the long-term safety particularly of modern hormonal infertility treatment in IVF programs is warranted.
Nyckelord
- Adolescent
- Adult
- Aged
- Cohort Studies
- Female
- Fertility Agents
- Female/*adverse effects/therapeutic use
- Follow-Up Studies
- Humans
- Incidence
- Infertility
- Female/*drug therapy
- Middle Aged
- Neoplasms
- Glandular and Epithelial/*chemically induced/*epidemiology
- Ovarian Neoplasms/*chemically induced/*epidemiology
- Sweden/epidemiology
- Young Adult
- MEDICINE
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Sanner, Karin, 1 ...
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Conner, Peter
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Bergfeldt, Kjell
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Dickman, Paul
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Sundfeldt, Karin ...
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Bergh, Torbjörn
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Hagenfeldt, Kers ...
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Janson, Per-Olof ...
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Nilsson, Staffan ...
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Persson, Ingemar
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- Artiklar i publikationen
- Fertil Steril
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Fertility and St ...
- Av lärosätet
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Göteborgs universitet
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Uppsala universitet
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Karolinska Institutet
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Chalmers tekniska högskola