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  • Albshesh, AhmadSheba Medical Center, Department of Gastroenterology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel (författare)

Effectiveness of Third-Class Biologic Treatment in Crohn's Disease : A Multi-Center Retrospective Cohort Study

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2021-06-29
  • MDPI,2021
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-93212
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-93212URI
  • https://doi.org/10.3390/jcm10132914DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: Multiple studies have described the effectiveness of ustekinumab (UST) and vedolizumab (VDZ) in patients with Crohn's disease (CD) failing anti- Tumor necrosis factors (TNFs); however, the effectiveness of VDZ or UST as a third-class biologic has not yet been described.Aims and Methods: In this retrospective multicenter cohort study, we aimed to investigate the effectiveness of VDZ and UST as a third-class biologic in patients with CD.Results: Two-hundred and four patients were included; 156/204 (76%) patients received VDZ as a second- and UST as a third-class therapy (group A); the remaining 48/204 (24%) patients received UST as a second- and VDZ as a third-class therapy (group B). At week 16-22, 87/156 (55.5%) patients and 27/48 (56.2%) in groups A and B, respectively, responded to treatment (p = 0.9); 41/156 (26.2%) and 15/48 (31.2%) were in clinical remission (p = 0.5). At week 52; 89/103 (86%) patients and 25/29 (86.2%) of the patients with available data had responded to third-class treatment in groups A and B, respectively (p = 0.9); 31/103 (30%) and 47/29 (24.1%) were in clinical remission (p = 0.5).Conclusion: Third-class biological therapy was effective in more than half of the patients with CD. No differences in effectiveness were detected between the use of VDZ and UST as a third-class agent.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Taylor, JoshuaDepartment of Gastroenterology, Montreal General Hospital, Montreal QC, Canada (författare)
  • Savarino, Edoardo, VDivision of Gastroenterology, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy (författare)
  • Truyens, MarieIBD Unit, Department of Gastroenterology, Ghent University Hospital, Ghent, Belgium (författare)
  • Armuzzi, AlessandroIBD Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy (författare)
  • Ribaldone, Davide G.Division of Gastroenterology, Department of Medical Sciences, University of Turin, Turin, Italy (författare)
  • Shitrit, Ariella Bar-GilShaare Zedek Medical Center, Faculty of Medicine, Digestive Diseases Institute, Hebrew University of Jerusalem, Jerusalem, Israel (författare)
  • Fibelman, MorineTel Aviv Medical Center, Department of Gastroenterology and Liver Diseases, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel (författare)
  • Molander, PauliinaAbdominal Center, Department of Gastroenterology, Helsinki University Hospital, Helsinki, Finland (författare)
  • Liefferinckx, ClaireDepartment of Gastroenterology, Erasme University Hopital, Brussels, Belgium (författare)
  • Nancey, StephaneDepartment of Gastroenterology, Hospices Civils de Lyon, University Claude Bernard Lyon, Lyon, France; INSERM, U1111, CIRI, Lyon, France (författare)
  • Korani, MohamedDivision of Gastroenterology, The Pennine Acute Hospitals NHS Trust, Manchester, UK; Manchester Academic Health Sciences, University of Manchester, Manchester, UK (författare)
  • Rutka, MariannFirst Department of Medicine, University of Szeged, Szeged, Hungary (författare)
  • Barreiro-de Acosta, ManuelIBD Unit, Gastroenterology Department, University Hospital of Santiago de Compostela, Santiago, Spain (författare)
  • Domislovic, ViktorDepartment of Gastroenterology, Hepatology, and Nutrition, University Hospital Centre Zagreb, Zagreb, Croatia (författare)
  • Suris, GerardDigestive System Service, Bellvitge University Hospital, Catalan Institute of Health, Barcelona, Spain (författare)
  • Eriksson, Carl,1981-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Gastroenterology(Swepub:oru)clen (författare)
  • Alves, CatarinaDepartment of Gastroenterology, Centro Hospitalar São João, Porto, Portugal (författare)
  • Mpitouli, AfroditiDepartment of Gastroenterology, Venizeleion General Hospital, Heraklion, Crete, Greece (författare)
  • di Jiang, CarolineDepartment of Gastroenterology, Addenbrooke’s Hospital, Cambridge University Hospitals, Cambridge, UK (författare)
  • Tepes, KatjaUniversity Medical Centre Ljubljana, Department of Gastroenterology, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia (författare)
  • Coletta, MarinaDepartment of Hepatology and Clinical Gastroenterology, ASST Santi Paolo e Carlo-Ospedale San Polo Universitario Milano Mariabeatrice, Milan, Italy (författare)
  • Foteinogiannopoulou, KalliopiDepartment of Gastroenterology, University Hospital of Heraklion, Crete, Greece (författare)
  • Gisbert, Javier P.Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Universidad Autónoma de Madrid, Madrid, Spain (författare)
  • Amir-Barak, HadarIBD Center, Division of Gastroenterology, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel and the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel (författare)
  • Attauabi, MohamedCopenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark (författare)
  • Seidelin, JakobDepartment of Gastroenterology, Herlev University Hospital, Copenhagen, Denmark (författare)
  • Afif, WaqqasDepartment of Gastroenterology, Montreal General Hospital, Montreal QC, Canada (författare)
  • Marinelli, CarlaDivision of Gastroenterology, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy (författare)
  • Lobaton, TrianaIBD Unit, Department of Gastroenterology, Ghent University Hospital, Ghent, Belgium (författare)
  • Pugliese, DanielaIBD Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy (författare)
  • Maharshak, NitsanTel Aviv Medical Center, Department of Gastroenterology and Liver Diseases, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel (författare)
  • Cremer, AnnelineDepartment of Gastroenterology, Erasme University Hopital, Brussels, Belgium (författare)
  • Limdi, Jimmy K.Division of Gastroenterology, The Pennine Acute Hospitals NHS Trust, Manchester, UK; Manchester Academic Health Sciences, University of Manchester, Manchester, UK (författare)
  • Molnár, TamásFirst Department of Medicine, University of Szeged, Szeged, Hungary (författare)
  • Otero-Alvarin, BorjaIBD Unit, Gastroenterology Department, University Hospital of Santiago de Compostela, Santiago, Spain (författare)
  • Krznaric, ZeljkoDepartment of Gastroenterology, Hepatology, and Nutrition, University Hospital Centre Zagreb, Zagreb, Croatia (författare)
  • Magro, FernandoDepartment of Gastroenterology, Centro Hospitalar São João, Porto, Portugal (författare)
  • Karmiris, KonstantinosDepartment of Gastroenterology, Venizeleion General Hospital, Heraklion, Crete, Greece (författare)
  • Raine, TimDepartment of Gastroenterology, Addenbrooke’s Hospital, Cambridge University Hospitals, Cambridge, UK (författare)
  • Drobne, DavidUniversity Medical Centre Ljubljana, Department of Gastroenterology, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia (författare)
  • Koutroubakis, IoannisDepartment of Gastroenterology, University Hospital of Heraklion, Crete, Greece (författare)
  • Chaparro, MariaCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Universidad Autónoma de Madrid, Madrid, Spain (författare)
  • Yanai, HenitIBD Center, Division of Gastroenterology, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel and the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel (författare)
  • Burisch, JohanCopenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark (författare)
  • Kopylov, UriSheba Medical Center, Department of Gastroenterology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel (författare)
  • Sheba Medical Center, Department of Gastroenterology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, IsraelDepartment of Gastroenterology, Montreal General Hospital, Montreal QC, Canada (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Clinical Medicine: MDPI10:132077-0383

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