Sökning: WFRF:(Schöchl Herbert) > Global Characterisa...
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001 | oai:DiVA.org:umu-179981 | |
003 | SwePub | |
008 | 210216s2020 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:oru-88032 | |
009 | oai:prod.swepub.kib.ki.se:145356640 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1799812 URI |
024 | 7 | a https://doi.org/10.1007/s12028-020-01151-72 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-880322 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1453566402 URI |
040 | a (SwePub)umud (SwePub)orud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Böhm, Julia K.u Department of Medicine, Faculty of Health, Institute for Research in Operative Medicine, Witten/Herdecke University, Cologne, Germany4 aut |
245 | 1 0 | a Global Characterisation of Coagulopathy in Isolated Traumatic Brain Injury (iTBI) :b A CENTER-TBI Analysis |
264 | c 2020-12-11 | |
264 | 1 | b Encyclopedia of Global Archaeology/Springer Verlag,c 2020 |
338 | a electronic2 rdacarrier | |
520 | a Background: Trauma-induced coagulopathy in patients with traumatic brain injury (TBI) is associated with high rates of complications, unfavourable outcomes and mortality. The mechanism of the development of TBI-associated coagulopathy is poorly understood.Methods: This analysis, embedded in the prospective, multi-centred, observational Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study, aimed to characterise the coagulopathy of TBI. Emphasis was placed on the acute phase following TBI, primary on subgroups of patients with abnormal coagulation profile within 4 h of admission, and the impact of pre-injury anticoagulant and/or antiplatelet therapy. In order to minimise confounding factors, patients with isolated TBI (iTBI) (n = 598) were selected for this analysis.Results: Haemostatic disorders were observed in approximately 20% of iTBI patients. In a subgroup analysis, patients with pre-injury anticoagulant and/or antiplatelet therapy had a twice exacerbated coagulation profile as likely as those without premedication. This was in turn associated with increased rates of mortality and unfavourable outcome post-injury. A multivariate analysis of iTBI patients without pre-injury anticoagulant therapy identified several independent risk factors for coagulopathy which were present at hospital admission. Glasgow Coma Scale (GCS) less than or equal to 8, base excess (BE) less than or equal to − 6, hypothermia and hypotension increased risk significantly.Conclusion: Consideration of these factors enables early prediction and risk stratification of acute coagulopathy after TBI, thus guiding clinical management. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
653 | a CENTER-TBI | |
653 | a Traumatic brain injury | |
653 | a Coagulopathy | |
653 | a Risk factors | |
700 | 1 | a Güting, Helgeu Department of Medicine, Faculty of Health, Institute for Research in Operative Medicine, Witten/Herdecke University, Cologne, Germany4 aut |
700 | 1 | a Thorn, Sophieu Emergency and Trauma Centre, Alfred Health, Melbourne, Australia4 aut |
700 | 1 | a Schäfer, Nadineu Department of Medicine, Faculty of Health, Institute for Research in Operative Medicine, Witten/Herdecke University, Cologne, Germany4 aut |
700 | 1 | a Rambach, Victoriau Department of Medicine, Faculty of Health, Institute for Research in Operative Medicine, Witten/Herdecke University, Cologne, Germany4 aut |
700 | 1 | a Schöchl, Herbertu Department of Anaesthesiology and Intensive Care, AUVA Trauma Hospital, Academic Teaching Hospital of the Paracelsus Medical University, Salzburg, Austria; Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Centre, Vienna, Austria4 aut |
700 | 1 | a Grottke, Oliveru Department of Anaesthesiology, RWTH Aachen University Hospital, Aachen, Germany4 aut |
700 | 1 | a Rossaint, Rolfu Department of Anaesthesiology, RWTH Aachen University Hospital, Aachen, Germany4 aut |
700 | 1 | a Stanworth, Simonu NHS Blood and Transplant, Oxford University Hospital NHS Foundation Trust, Headley Way, Oxford, UK4 aut |
700 | 1 | a Curry, Nicolau NHS Blood and Transplant, Oxford University Hospital NHS Foundation Trust, Headley Way, Oxford, UK4 aut |
700 | 1 | a Lefering, Rolfu Department of Medicine, Faculty of Health, Institute for Research in Operative Medicine, Witten/Herdecke University, Cologne, Germany4 aut |
700 | 1 | a Maegele, Marcu Department of Medicine, Faculty of Health, Institute for Research in Operative Medicine, Witten/Herdecke University, Cologne, Germany; MaeDepartment of Traumatology, Orthopaedic Surgery and Sports Traumatology, Cologne-Merheim Medical Centre (CMMC), Witten/Herdecke University, Campus Cologne-Merheim, Cologne, Germany4 aut |
700 | 1 | a Vámos, Zoltán4 aut |
700 | 1 | a Koskinen, Lars-Owe D.,c Professor,d 1955-u Umeå universitet,Neurovetenskaper4 ctb0 (Swepub:umu)lako0002 |
700 | 1 | a Brorsson, Camillau Umeå universitet,Anestesiologi och intensivvård0 (Swepub:umu)brca0001 |
700 | 1 | a Oresic, Matej,d 1967-u Örebro universitet,Institutionen för medicinska vetenskaper0 (Swepub:oru)moc |
710 | 2 | a Department of Medicine, Faculty of Health, Institute for Research in Operative Medicine, Witten/Herdecke University, Cologne, Germanyb Emergency and Trauma Centre, Alfred Health, Melbourne, Australia4 org |
773 | 0 | t Neurocritical Cared : Encyclopedia of Global Archaeology/Springer Verlagg 35:1, s. 184-196q 35:1<184-196x 1541-6933x 1556-0961 |
856 | 4 | u https://doi.org/10.1007/s12028-020-01151-7y Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1528691/FULLTEXT02.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://link.springer.com/content/pdf/10.1007/s12028-020-01151-7.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-179981 |
856 | 4 8 | u https://doi.org/10.1007/s12028-020-01151-7 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-88032 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:145356640 |
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