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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005590naa a2200913 4500
001oai:DiVA.org:umu-177753
003SwePub
008201217s2021 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1777532 URI
0247 a https://doi.org/10.1158/1055-9965.EPI-20-08552 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Aglago, Elom K.4 aut
2451 0a Soluble Receptor for Advanced Glycation End-products (sRAGE) and Colorectal Cancer Risk :b A Case-Control Study Nested within a European Prospective Cohort
264 1b American Association for Cancer Research,c 2021
338 a print2 rdacarrier
520 a BACKGROUND: Overexpression of the receptor for advanced glycation end-product (RAGE) has been associated with chronic inflammation, which in turn has been associated with increased colorectal cancer risk. Soluble RAGE (sRAGE) competes with RAGE to bind its ligands, thus potentially preventing RAGE-induced inflammation.METHODS: To investigate whether sRAGE and related genetic variants are associated with colorectal cancer risk, we conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC). Plasma sRAGE concentrations were measured by ELISA in 1,361 colorectal cancer matched case-control sets. Twenty-four SNPs encoded in the genes associated with sRAGE concentrations were available for 1,985 colorectal cancer cases and 2,220 controls. Multivariable adjusted ORs and 95% confidence intervals (CIs) were computed using conditional and unconditional logistic regression for colorectal cancer risk and circulating sRAGE and SNPs, respectively.RESULTS: Higher sRAGE concentrations were inversely associated with colorectal cancer (ORQ5vs.Q1, 0.77; 95% CI, 0.59-1.00). Sex-specific analyses revealed that the observed inverse risk association was restricted to men (ORQ5vs.Q1, 0.63; 95% CI, 0.42-0.94), whereas no association was observed in women (ORQ5vs.Q1, 1.00; 95% CI, 0.68-1.48; Pheterogeneity for sex = 0.006). Participants carrying minor allele of rs653765 (promoter region of ADAM10) had lower colorectal cancer risk (C vs. T, OR, 0.90; 95% CI, 0.82-0.99).CONCLUSIONS: Prediagnostic sRAGE concentrations were inversely associated with colorectal cancer risk in men, but not in women. An SNP located within ADAM10 gene, pertaining to RAGE shedding, was associated with colorectal cancer risk.IMPACT: Further studies are needed to confirm our observed sex difference in the association and better explore the potential involvement of genetic variants of sRAGE in colorectal cancer development.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
653 a sRAGE
653 a colorectal cancer
653 a advanced glycation end-product
653 a inflammation
653 a polymorphism
653 a Cancer Epidemiology
653 a cancerepidemiologi
7001 a Rinaldi, Sabina4 aut
7001 a Freisling, Heinz4 aut
7001 a Jiao, Li4 aut
7001 a Hughes, David J.4 aut
7001 a Fedirko, Veronika4 aut
7001 a Schalkwijk, Casper G.4 aut
7001 a Weiderpass, Elisabete4 aut
7001 a Dahm, Christina C.4 aut
7001 a Overvad, Kim4 aut
7001 a Eriksen, Anne Kirstine4 aut
7001 a Kyrø, Cecilie4 aut
7001 a Boutron-Ruault, Marie-Christine4 aut
7001 a Rothwell, Joseph A.4 aut
7001 a Severi, Gianluca4 aut
7001 a Katzke, Verena4 aut
7001 a Kühn, Tilman4 aut
7001 a Schulze, Matthias B.4 aut
7001 a Aleksandrova, Krasimira4 aut
7001 a Masala, Giovanna4 aut
7001 a Krogh, Vittorio4 aut
7001 a Panico, Salvatore4 aut
7001 a Tumino, Rosario4 aut
7001 a Naccarati, Alessio4 aut
7001 a Bueno-de-Mesquita, Bas4 aut
7001 a van Gils, Carla H.4 aut
7001 a Sandanger, Torkjel M.4 aut
7001 a Gram, Inger T.4 aut
7001 a Skeie, Guri4 aut
7001 a Quirós, J. Ramón4 aut
7001 a Jakszyn, Paula4 aut
7001 a Sánchez, Maria-Jose4 aut
7001 a Amiano, Pilar4 aut
7001 a Huerta, José María4 aut
7001 a Ardanaz, Eva4 aut
7001 a Johansson, Ingegerdu Umeå universitet,Onkologi,Institutionen för odontologi4 aut0 (Swepub:umu)injo0003
7001 a Harlid, Sophia,d 1978-u Umeå universitet,Onkologi4 aut0 (Swepub:umu)soha0105
7001 a Perez-Cornago, Aurora4 aut
7001 a Mayén, Ana-Lucia4 aut
7001 a Cordova, Reynalda4 aut
7001 a Gunter, Marc J.4 aut
7001 a Vineis, Paolo4 aut
7001 a Cross, Amanda J.4 aut
7001 a Riboli, Elio4 aut
7001 a Jenab, Mazda4 aut
7102 a Umeå universitetb Onkologi4 org
7730 t Cancer Epidemiology, Biomarkers and Preventiond : American Association for Cancer Researchg 30:1, s. 182-192q 30:1<182-192x 1055-9965x 1538-7755
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-177753
8564 8u https://doi.org/10.1158/1055-9965.EPI-20-0855

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