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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005425naa a2200577 4500
001oai:DiVA.org:uu-363094
003SwePub
008181016s2018 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3630942 URI
0247 a https://doi.org/10.1016/j.bcmd.2018.07.0042 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Tricoci, Pierluigiu Duke Univ, Duke Clin Res Inst, Durham, NC USA4 aut
2451 0a Effects of genetic variation in protease activated receptor 4 after an acute coronary syndrome :b Analysis from the TRACER trial
264 1b Elsevier BV,c 2018
338 a print2 rdacarrier
520 a Variation in platelet response to thrombin may affect the safety and efficacy of PAR antagonism. The Thr120 variant of the common single nucleotide polymorphism (SNP) rs773902 in the protease-activated receptor (PAR) 4 gene is associated with higher platelet aggregation compared to the Ala120 variant. We investigated the relationship between the rs773902 SNP with major bleeding and ischemic events, safety, and efficacy of PAR1 inhibition in 6177 NSTE ACS patients in the TRACER trial. There was a lower rate of GUSTO moderate/severe bleeding in patients with the Thr120 variant. The difference was driven by a lower rate in the smaller homozygous group (recessive model, HR 0.13 [0.02-0.92] P= 0.042). No significant differences were observed in the ischemic outcomes. The excess in bleeding observed with PAR1 inhibition was attenuated in patients with the Thr120 variant, but the interactions were not statistically significant. In summary, lower major bleeding rates were observed in the overall TRACER cohort with the hyperreactive PAR4 Thr120 variant. The increase in bleeding with vorapaxar was attenuated with the Thr120 variant, but we could not demonstrate an interaction with PAR1 inhibition. These findings warrant further exploration, including those of African ancestry where the A allele (Thr120) frequency is similar to 65%.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Hematologi0 (SwePub)302022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Hematology0 (SwePub)302022 hsv//eng
653 a Platelets
653 a PAR1
653 a PAR4
653 a Bleeding
653 a Pharmacogenetics
7001 a Neely, Meganu Duke Univ, Duke Clin Res Inst, Durham, NC USA4 aut
7001 a Whitley, Michael J.u Thomas Jefferson Univ, Dept Med, Sidney Kimmel Med Coll, Philadelphia, PA 19107 USA;Thomas Jefferson Univ, Cardeza Fdn Hematol Res, Sidney Kimmel Med Coll, Philadelphia, PA 19107 USA4 aut
7001 a Edelstein, Leonard C.u Thomas Jefferson Univ, Dept Med, Sidney Kimmel Med Coll, Philadelphia, PA 19107 USA;Thomas Jefferson Univ, Cardeza Fdn Hematol Res, Sidney Kimmel Med Coll, Philadelphia, PA 19107 USA4 aut
7001 a Simon, Lukas M.u Baylor Coll Med, Dept Human & Mol Genet, Houston, TX 77030 USA4 aut
7001 a Shaw, Chadu Rice Univ, Dept Stat, Houston, TX 77251 USA;Baylor Coll Med, Dept Human & Mol Genet, Houston, TX 77030 USA4 aut
7001 a Fortina, Paolou Thomas Jefferson Univ, Canc Genom & Bioinformat Lab, Sidney Kimmel Canc Ctr, Philadelphia, PA 19107 USA4 aut
7001 a Moliterno, David J.u Univ Kentucky, Gill Heart Inst, Lexington, KY USA;Univ Kentucky, Div Cardiovasc Med, Lexington, KY USA4 aut
7001 a Armstrong, Paul W.u Univ Alberta, Div Cardiol, Edmonton, AB, Canada4 aut
7001 a Aylward, Philipu Flinders Med Ctr, Div Med Cardiac & Crit Care Serv, Bedford Pk, SA, Australia4 aut
7001 a White, Harveyu Auckland City Hosp, Green Lane Cardiovasc Serv, Auckland, New Zealand4 aut
7001 a Van de Werf, Fransu Univ Leuven, Dept Cardiovasc Sci, Leuven, Belgium4 aut
7001 a Jennings, Lisa K.u Univ Tennessee, Hlth Sci Ctr, Memphis, TN USA;CirQuest Labs LLC, Memphis, TN USA4 aut
7001 a Wallentin, Lars,d 1943-u Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)larswall
7001 a Held, Claes,d 1956-u Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi4 aut0 (Swepub:uu)clahe947
7001 a Harrington, Robert A.u Stanford Univ, Dept Med, Stanford, CA 94305 USA4 aut
7001 a Mahaffey, Kenneth W.u Stanford Univ, Dept Med, Stanford, CA 94305 USA4 aut
7001 a Bray, Paul F.u Univ Utah, Dept Internal Med, Div Hematol & Hematol Malignancies, Salt Lake City, UT 84112 USA;Univ Utah, Mol Med Program, Salt Lake City, UT USA4 aut
7102 a Duke Univ, Duke Clin Res Inst, Durham, NC USAb Thomas Jefferson Univ, Dept Med, Sidney Kimmel Med Coll, Philadelphia, PA 19107 USA;Thomas Jefferson Univ, Cardeza Fdn Hematol Res, Sidney Kimmel Med Coll, Philadelphia, PA 19107 USA4 org
7730 t Blood Cells, Molecules & Diseasesd : Elsevier BVg 72, s. 37-43q 72<37-43x 1079-9796x 1096-0961
8564 u https://europepmc.org/articles/pmc6097632?pdf=render
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-363094
8564 8u https://doi.org/10.1016/j.bcmd.2018.07.004

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