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WFRF:(Sisay Joof Fatou)
 

Sökning: WFRF:(Sisay Joof Fatou) > Lack of association...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003355naa a2200505 4500
001oai:DiVA.org:su-25618
003SwePub
008081106s2009 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-256182 URI
0247 a https://doi.org/10.1371/journal.pone.00042062 DOI
040 a (SwePub)su
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Mangano, Valentina Du Stockholms universitet,Wenner-Grens institut4 aut
2451 0a Lack of association of Interferon Regulatory Factor 1 with severe malaria in affected child‐parental trio studies across three African populations
264 c 2009-01-15
264 1b Public Library of Science (PLoS),c 2009
338 a print2 rdacarrier
520 a Interferon Regulatory Factor 1 (IRF-1) is a member of the IRF family of transcription factors, which have key and diverse roles in the gene-regulatory networks of the immune system. IRF-1 has been described as a critical mediator of IFN-gamma signalling and as the major player in driving TH1 type responses. It is therefore likely to be crucial in both innate and adaptive responses against intracellular pathogens such as Plasmodium falciparum. Polymorphisms at the human IRF1 locus have been previously found to be associated with the ability to control P. falciparum infection in populations naturally exposed to malaria. In order to test whether genetic variation at the IRF1 locus also affects the risk of developing severe malaria, we performed a family-based test of association for 18 Single Nucleotide Polymorphisms (SNPs) across the gene in three African populations, using genotype data from 961 trios consisting of one affected child and his/her two parents (555 from The Gambia, 204 from Kenya and 202 from Malawi). No significant association with severe malaria or severe malaria subphenotypes (cerebral malaria and severe malaria anaemia) was observed for any of the SNPs/haplotypes tested in any of the study populations. Our results offer no evidence that the molecular pathways regulated by the transcription factor IRF-1 are involved in the immune-based pathogenesis of severe malaria.
7001 a Clark, Taane G4 aut
7001 a Auburn, Sarah4 aut
7001 a Diakite, Mahamadou4 aut
7001 a Fry, Andrew E4 aut
7001 a Campino, Susana4 aut
7001 a Green, Angela4 aut
7001 a Richardson, Anna4 aut
7001 a Jallow, Muminatou4 aut
7001 a Sisay-Joof, Fatou4 aut
7001 a Pinder, Margaret4 aut
7001 a Griffiths, Michael J4 aut
7001 a Peshu, Norbert4 aut
7001 a Williams, Thomas N4 aut
7001 a Marsh, Kevin4 aut
7001 a Molyneux, Malcolm E4 aut
7001 a Taylor, Terrie E4 aut
7001 a Modiano, David4 aut
7001 a Kwiatkowski, Dominic P4 aut
7001 a Rockett, Kirk A4 aut
7102 a Stockholms universitetb Wenner-Grens institut4 org
7730 t PLoS ONEd : Public Library of Science (PLoS)g 4:1, s. e4206-q 4:1<e4206-x 1932-6203
8564 u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0004206&type=printable
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-25618
8564 8u https://doi.org/10.1371/journal.pone.0004206

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