SabA is the H. pylori hemagglutinin and is polymorphic in binding to sialylated glycans.

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MARC

Aspholm, Marina (author)

SabA is the H. pylori hemagglutinin and is polymorphic in binding to sialylated glycans.

Article/chapterEnglish2006

Publisher, publication year, extent ...

2006-10-27
Public Library of Science (PLoS),2006

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LIBRIS-ID:oai:gup.ub.gu.se/60767
https://gup.ub.gu.se/publication/60767URI
https://doi.org/10.1371/journal.ppat.0020110DOI
https://lup.lub.lu.se/record/682092URI
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-6639URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:112526111URI

Supplementary language notes

Language:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Adherence of Helicobacter pylori to inflamed gastric mucosa is dependent on the sialic acid-binding adhesin (SabA) and cognate sialylated/fucosylated glycans on the host cell surface. By in situ hybridization, H. pylori bacteria were observed in close association with erythrocytes in capillaries and post-capillary venules of the lamina propria of gastric mucosa in both infected humans and Rhesus monkeys. In vivo adherence of H. pylori to erythrocytes may require molecular mechanisms similar to the sialic acid-dependent in vitro agglutination of erythrocytes (i.e., sialic acid-dependent hemagglutination). In this context, the SabA adhesin was identified as the sialic acid-dependent hemagglutinin based on sialidase-sensitive hemagglutination, binding assays with sialylated glycoconjugates, and analysis of a series of isogenic sabA deletion mutants. The topographic presentation of binding sites for SabA on the erythrocyte membrane was mapped to gangliosides with extended core chains. However, receptor mapping revealed that the NeuAcalpha2-3Gal-disaccharide constitutes the minimal sialylated binding epitope required for SabA binding. Furthermore, clinical isolates demonstrated polymorphism in sialyl binding and complementation analysis of sabA mutants demonstrated that polymorphism in sialyl binding is an inherent property of the SabA protein itself. Gastric inflammation is associated with periodic changes in the composition of mucosal sialylation patterns. We suggest that dynamic adaptation in sialyl-binding properties during persistent infection specializes H. pylori both for individual variation in mucosal glycosylation and tropism for local areas of inflamed and/or dysplastic tissue.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Mikrobiologi inom det medicinska området hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Microbiology in the medical area hsv//eng
Adhesins
Bacterial
genetics
metabolism
Adsorption
Animals
Antigens
Bacterial
metabolism
Bacterial Adhesion
Binding Sites
Binding
Competitive
Capillaries
Erythrocytes
metabolism
microbiology
Gangliosides
metabolism
Gastric Mucosa
blood supply
microbiology
Gene Deletion
Helicobacter Infections
immunology
microbiology
Helicobacter pylori
metabolism
physiology
Hemagglutination
Hemagglutinins
metabolism
Humans
Macaca mulatta
N-Acetylneuraminic Acid
metabolism
Oligosaccharides
metabolism
Polysaccharides
metabolism
Venules
Adhesins; Bacterial/genetics/*metabolism

Added entries (persons, corporate bodies, meetings, titles ...)

Olfat, Farzad O (author)
Nordén, JennyUmeå universitet,Institutionen för medicinsk kemi och biofysik(Swepub:umu)jeynon99 (author)
Sondén, Berit (author)
Lundberg, CarinaUmeå universitet,Institutionen för medicinsk kemi och biofysik (author)
Sjöström, RolfUmeå universitet,Institutionen för medicinsk kemi och biofysik(Swepub:umu)rosj0001 (author)
Altraja, Siiri (author)
Odenbreit, Stefan (author)
Haas, Rainer (author)
Wadström, TorkelLund University,Lunds universitet,Avdelningen för medicinsk mikrobiologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Medical Microbiology,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)mmb-twa (author)
Engstrand, LarsKarolinska Institutet (author)
Semino-Mora, Cristina (author)
Liu, Hui (author)
Dubois, André (author)
Teneberg, Susann,1955Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology(Swepub:gu)xtensu (author)
Arnqvist, AnnaUmeå universitet,Institutionen för medicinsk kemi och biofysik(Swepub:umu)anar0001 (author)
Borén, ThomasUmeå universitet,Institutionen för medicinsk kemi och biofysik(Swepub:umu)thbo0001 (author)
Umeå universitetInstitutionen för medicinsk kemi och biofysik (creator_code:org_t)

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In:PLoS pathogens: Public Library of Science (PLoS)2:101553-73741553-7366

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By the author/editor: Aspholm, Marina; Olfat, Farzad O; Nordén, Jenny; Sondén, Berit; Lundberg, Carina; Sjöström, Rolf; show more...; Altraja, Siiri; Odenbreit, Stefa ...; Haas, Rainer; Wadström, Torkel; Engstrand, Lars; Semino-Mora, Cri ...; Liu, Hui; Dubois, André; Teneberg, Susann ...; Arnqvist, Anna; Borén, Thomas; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Microbiology in ...

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By the university: University of Gothenburg; Lund University; Umeå University; Karolinska Institutet

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