WFRF:(Sjöström Rolf)
Sökning: WFRF:(Sjöström Rolf) > (2005-2009) > SabA is the H. pylo...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 06610naa a2201117 4500 | |
| 001 | oai:gup.ub.gu.se/60767 | |
| 003 | SwePub | |
| 008 | 240528s2006 | |||||||||||000 ||eng| | |
| 009 | oai:lup.lub.lu.se:0ff64df6-179c-4a97-81b0-db451953d6f8 | |
| 009 | oai:DiVA.org:umu-6639 | |
| 009 | oai:prod.swepub.kib.ki.se:112526111 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/607672 URI |
| 024 | 7 | a https://doi.org/10.1371/journal.ppat.00201102 DOI |
| 024 | 7 | a https://lup.lub.lu.se/record/6820922 URI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-66392 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1125261112 URI |
| 040 | a (SwePub)gud (SwePub)lud (SwePub)umud (SwePub)ki | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Aspholm, Marina4 aut |
| 245 | 1 0 | a SabA is the H. pylori hemagglutinin and is polymorphic in binding to sialylated glycans. |
| 264 | c 2006-10-27 | |
| 264 | 1 | b Public Library of Science (PLoS),c 2006 |
| 520 | a Adherence of Helicobacter pylori to inflamed gastric mucosa is dependent on the sialic acid-binding adhesin (SabA) and cognate sialylated/fucosylated glycans on the host cell surface. By in situ hybridization, H. pylori bacteria were observed in close association with erythrocytes in capillaries and post-capillary venules of the lamina propria of gastric mucosa in both infected humans and Rhesus monkeys. In vivo adherence of H. pylori to erythrocytes may require molecular mechanisms similar to the sialic acid-dependent in vitro agglutination of erythrocytes (i.e., sialic acid-dependent hemagglutination). In this context, the SabA adhesin was identified as the sialic acid-dependent hemagglutinin based on sialidase-sensitive hemagglutination, binding assays with sialylated glycoconjugates, and analysis of a series of isogenic sabA deletion mutants. The topographic presentation of binding sites for SabA on the erythrocyte membrane was mapped to gangliosides with extended core chains. However, receptor mapping revealed that the NeuAcalpha2-3Gal-disaccharide constitutes the minimal sialylated binding epitope required for SabA binding. Furthermore, clinical isolates demonstrated polymorphism in sialyl binding and complementation analysis of sabA mutants demonstrated that polymorphism in sialyl binding is an inherent property of the SabA protein itself. Gastric inflammation is associated with periodic changes in the composition of mucosal sialylation patterns. We suggest that dynamic adaptation in sialyl-binding properties during persistent infection specializes H. pylori both for individual variation in mucosal glycosylation and tropism for local areas of inflamed and/or dysplastic tissue. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng |
| 653 | a Adhesins | |
| 653 | a Bacterial | |
| 653 | a genetics | |
| 653 | a metabolism | |
| 653 | a Adsorption | |
| 653 | a Animals | |
| 653 | a Antigens | |
| 653 | a Bacterial | |
| 653 | a metabolism | |
| 653 | a Bacterial Adhesion | |
| 653 | a Binding Sites | |
| 653 | a Binding | |
| 653 | a Competitive | |
| 653 | a Capillaries | |
| 653 | a Erythrocytes | |
| 653 | a metabolism | |
| 653 | a microbiology | |
| 653 | a Gangliosides | |
| 653 | a metabolism | |
| 653 | a Gastric Mucosa | |
| 653 | a blood supply | |
| 653 | a microbiology | |
| 653 | a Gene Deletion | |
| 653 | a Helicobacter Infections | |
| 653 | a immunology | |
| 653 | a microbiology | |
| 653 | a Helicobacter pylori | |
| 653 | a metabolism | |
| 653 | a physiology | |
| 653 | a Hemagglutination | |
| 653 | a Hemagglutinins | |
| 653 | a metabolism | |
| 653 | a Humans | |
| 653 | a Macaca mulatta | |
| 653 | a N-Acetylneuraminic Acid | |
| 653 | a metabolism | |
| 653 | a Oligosaccharides | |
| 653 | a metabolism | |
| 653 | a Polysaccharides | |
| 653 | a metabolism | |
| 653 | a Venules | |
| 653 | a Adhesins; Bacterial/genetics/*metabolism | |
| 700 | 1 | a Olfat, Farzad O4 aut |
| 700 | 1 | a Nordén, Jennyu Umeå universitet,Institutionen för medicinsk kemi och biofysik4 aut0 (Swepub:umu)jeynon99 |
| 700 | 1 | a Sondén, Berit4 aut |
| 700 | 1 | a Lundberg, Carinau Umeå universitet,Institutionen för medicinsk kemi och biofysik4 aut |
| 700 | 1 | a Sjöström, Rolfu Umeå universitet,Institutionen för medicinsk kemi och biofysik4 aut0 (Swepub:umu)rosj0001 |
| 700 | 1 | a Altraja, Siiri4 aut |
| 700 | 1 | a Odenbreit, Stefan4 aut |
| 700 | 1 | a Haas, Rainer4 aut |
| 700 | 1 | a Wadström, Torkelu Lund University,Lunds universitet,Avdelningen för medicinsk mikrobiologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Medical Microbiology,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)mmb-twa |
| 700 | 1 | a Engstrand, Larsu Karolinska Institutet4 aut |
| 700 | 1 | a Semino-Mora, Cristina4 aut |
| 700 | 1 | a Liu, Hui4 aut |
| 700 | 1 | a Dubois, André4 aut |
| 700 | 1 | a Teneberg, Susann,d 1955u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology4 aut0 (Swepub:gu)xtensu |
| 700 | 1 | a Arnqvist, Annau Umeå universitet,Institutionen för medicinsk kemi och biofysik4 aut0 (Swepub:umu)anar0001 |
| 700 | 1 | a Borén, Thomasu Umeå universitet,Institutionen för medicinsk kemi och biofysik4 aut0 (Swepub:umu)thbo0001 |
| 710 | 2 | a Umeå universitetb Institutionen för medicinsk kemi och biofysik4 org |
| 773 | 0 | t PLoS pathogensd : Public Library of Science (PLoS)g 2:10q 2:10x 1553-7374x 1553-7366 |
| 856 | 4 | u https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.0020110&type=printable |
| 856 | 4 | u http://dx.doi.org/10.1371/journal.ppat.0020110x freey FULLTEXT |
| 856 | 4 | u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=17121461&dopt=Citation |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/60767 |
| 856 | 4 8 | u https://doi.org/10.1371/journal.ppat.0020110 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/682092 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-6639 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:112526111 |
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