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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007602naa a2200493 4500
001oai:gup.ub.gu.se/180090
003SwePub
008240528s2013 | |||||||||||000 ||eng|
009oai:DiVA.org:liu-132793
0247 a https://gup.ub.gu.se/publication/1800902 URI
0247 a https://doi.org/10.1096/fj.13-2300112 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1327932 URI
040 a (SwePub)gud (SwePub)liu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Järlestedt, Katarinau Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology,Perinatal Center, University of Gothenburg, Gothenburg, Sweden4 aut0 (Swepub:gu)xpugka
2451 0a Receptor for complement peptide C3a: a therapeutic target for neonatal hypoxic-ischemic brain injury.
264 c 2013-06-04
264 1a Bethesda :b Wiley,c 2013
520 a Complement is an essential component of inflammation that plays a role in ischemic brain injury. Recent reports demonstrate novel functions of complement in normal and diseased CNS, such as regulation of neurogenesis and synapse elimination. Here, we examined the role of complement-derived peptide C3a in unilateral hypoxia-ischemia (HI), a model of neonatal HI encephalopathy. HI injury was induced at postnatal day 9 (P9), and loss of hippocampal tissue was determined on P31. We compared WT mice with transgenic mice expressing C3a under the control of glial fibrillary acidic protein promoter, which express biologically active C3a only in CNS and without the requirement of a priori complement activation. Further, we injected C3a peptide into the lateral cerebral ventricle of mice lacking the C3a receptor (C3aR) and WT mice and assessed HI-induced memory impairment 41 d later. We found that HI-induced tissue loss in C3a overexpressing mice was reduced by 50% compared with WT mice. C3a peptide injected 1 h after HI protected WT but not C3aR-deficient mice against HI-induced memory impairment. Thus, C3a acting through its canonical receptor ameliorates behavioral deficits after HI injury, and C3aR is a novel therapeutic target for the treatment of neonatal HI encephalopathy.-Järlestedt, K., Rousset, C. I., Ståhlberg, A., Sourkova, H., Atkins, A. L., Thornton, C., Barnum, S. R., Wetsel, R. A., Dragunow, M., Pekny, M., Mallard, C., Hagberg, H., Pekna, M. Receptor for complement peptide C3a: a therapeutic target for neonatal hypoxic-ischemic brain injury.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaper0 (SwePub)3012 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicine0 (SwePub)3012 hsv//eng
653 a behavioral deficit
653 a mice
7001 a Rousset, Catherine Iu Centre for the Developing Brain, King's College, London, UK4 aut0 (Swepub:gu)xrouca
7001 a Ståhlberg, Anders,d 1975u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation,Center for Brain Repair and Rehabilitation, Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden4 aut0 (Swepub:gu)xsandw
7001 a Sourkova, Hanau Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation,Center for Brain Repair and Rehabilitation, Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden4 aut
7001 a Atkins, Alison Lu Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation,Center for Brain Repair and Rehabilitation, Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden4 aut0 (Swepub:liu)aliat41
7001 a Thornton, Claireu Centre for the Developing Brain, King's College, London, UK4 aut
7001 a Barnum, Scott Ru Department of Microbiology, University of Alabama, Birmingham, Alabama, USA4 aut
7001 a Wetsel, Rick Au Research Center for Immunology and Autoimmune Diseases, Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas–Houston, Houston, Texas, USA4 aut
7001 a Dragunow, Mikeu Department of Pharmacology and The National Research Centre for Growth and Development, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand4 aut
7001 a Pekny, Milos,d 1965u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation,Center for Brain Repair and Rehabilitation, Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden4 aut0 (Swepub:gu)xpekmi
7001 a Mallard, Carina,d 1963u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology,Perinatal Center, University of Gothenburg, Gothenburg, Sweden4 aut0 (Swepub:gu)xmallc
7001 a Hagberg, Henrik,d 1955u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology,Institute of Neuroscience and Physiology, Department of Physiology,Perinatal Center, Department of Obstetrics and Gynecology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Centre for the Developing Brain, King's College, London, UK4 aut0 (Swepub:gu)xhaghe
7001 a Pekna, Marcela,d 1966u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation,Center for Brain Repair and Rehabilitation, Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden4 aut0 (Swepub:gu)xpekma
7102 a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi4 org
7730 t FASEB journal : official publication of the Federation of American Societies for Experimental Biologyd Bethesda : Wileyg 27:9, s. 3797-3804q 27:9<3797-3804x 1530-6860x 0892-6638
7730 t The FASEB Journald Bethesda : Wileyg 27:9, s. 3797-3804q 27:9<3797-3804x 0892-6638
8564 8u https://gup.ub.gu.se/publication/180090
8564 8u https://doi.org/10.1096/fj.13-230011
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-132793

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