Validation and clinical value of the MANAGE-PD tool : A clinician-reported tool to identify Parkinson's disease patients inadequately controlled on oral medications

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Antonini, AngeloUniversity of Padova (författare)

Validation and clinical value of the MANAGE-PD tool : A clinician-reported tool to identify Parkinson's disease patients inadequately controlled on oral medications

Artikel/kapitelEngelska2021

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Elsevier BV,2021
8 s.

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LIBRIS-ID:oai:lup.lub.lu.se:cf15f09a-fa25-42e0-8dfb-81101f7f06f2
https://lup.lub.lu.se/record/cf15f09a-fa25-42e0-8dfb-81101f7f06f2URI
https://doi.org/10.1016/j.parkreldis.2021.10.009DOI

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Språk:engelska
Sammanfattning på:engelska

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Ämneskategori:art swepub-publicationtype
Ämneskategori:ref swepub-contenttype

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Introduction: Making Informed Decisions to Aid Timely Management of Parkinson's Disease (MANAGE-PD) is a clinician-reported tool designed to facilitate timely identification and management of patients with advancing Parkinson's disease (PD) with suboptimal symptom control while on standard therapy. The objective of this study was to evaluate the validity and clinical value of the tool. Methods: Driven by structured inputs from a steering committee and panel of PD experts, the tool was developed to classify patients into 3 categories. Validity and clinical value were elucidated using a two-pronged approach: (i) hypothetical patient vignettes (n = 10) developed based on the MANAGE-PD tool and rated by 17 PD specialists and 400 general neurologists (GN) and (ii) patients with PD (n = 2546) managed in real-world clinical settings. Vignette validity was based on concordance between PD experts’ clinical judgement and MANAGE-PD vignette categorization. Patient-level data was used for known-group comparisons (validity) and discordant pair analysis (clinical value). Results: The tool demonstrated strong validity and clinical value among PD specialists (intraclass coefficient [ICC] 0.843; Fleiss weighted kappa [ƙweighted] 0.79) and GN (ICC 0.690; ƙweighted 0.65) using patient vignettes. MANAGE-PD also demonstrated real-world validity and clinical value based on ability to identify patients with incrementally higher clinical, economic, and humanistic PD burden across categories of the tool (p < 0.01). Conclusions: MANAGE-PD demonstrated robust validity and clinical value in identifying patients with suboptimal PD symptom control. Clinical use of MANAGE-PD may complement treatment decision-making and facilitate timely and comprehensive management of patients with advancing PD.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
Clinician decision-making
Clinician-reported
Continuous subcutaneous apomorphine infusion (CSAI)
Deep brain stimulation (DBS)
Dyskinesia
Levodopa-carbidopa intestinal gel (LCIG)
MANAGE-PD
Motor fluctuations
Parkinson disease
Patient identification
Wearing-off

Biuppslag (personer, institutioner, konferenser, titlar ...)

Odin, PerLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Restorative Parkinson Unit,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups(Swepub:lu)med-poi (författare)
Schmidt, PeterEast Carolina University (författare)
Cubillos, Fernando (författare)
Standaert, David G. (författare)
Henriksen, ToveBispebjerg Hospital (författare)
Jimenez-Shahed, JoohiIcahn School of Medicine at Mount Sinai (författare)
Alobaidi, AliAbbVie Inc.,University of Illinois at Chicago (författare)
Jalundhwala, Yash J.AbbVie Inc. (författare)
Bao, YanjunAbbVie Inc. (författare)
Zamudio, JorgeAbbVie Inc. (författare)
Parra, Juan CarlosAbbVie Inc. (författare)
Kukreja, PavnitAbbVie Inc. (författare)
Onuk, KorayAbbVie Inc. (författare)
Skalicky, Anne M.National Institutes of Health, United States (författare)
Kleinman, LeahNational Institutes of Health, United States (författare)
Jones, Eddie (författare)
Metz, Sharon (författare)
Fernandez, Hubert H.Cleveland Clinic Foundation (författare)
University of PadovaNeurologi, Lund (creator_code:org_t)

Sammanhörande titlar

Ingår i:Parkinsonism and Related Disorders: Elsevier BV92, s. 59-661353-8020

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Neurologi

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Av lärosätet: Lunds universitet

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