Sökning: WFRF:(Stefansson Jon G) > (2011) > European genome-wid...
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000 | 05973naa a2201177 4500 | |
001 | oai:gup.ub.gu.se/147916 | |
003 | SwePub | |
008 | 240528s2011 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:123341199 | |
024 | 7 | a https://gup.ub.gu.se/publication/1479162 URI |
024 | 7 | a https://doi.org/10.1093/hmg/ddr3032 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1233411992 URI |
040 | a (SwePub)gud (SwePub)ki | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Rafnar, Thorunn4 aut |
245 | 1 0 | a European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene. |
264 | c 2011-07-12 | |
264 | 1 | b Oxford University Press (OUP),c 2011 |
520 | a Three genome-wide association studies in Europe and the USA have reported eight urinary bladder cancer (UBC) susceptibility loci. Using extended case and control series and 1000 Genomes imputations of 5 340 737 single-nucleotide polymorphisms (SNPs), we searched for additional loci in the European GWAS. The discovery sample set consisted of 1631 cases and 3822 controls from the Netherlands and 603 cases and 37 781 controls from Iceland. For follow-up, we used 3790 cases and 7507 controls from 13 sample sets of European and Iranian ancestry. Based on the discovery analysis, we followed up signals in the urea transporter (UT) gene SLC14A. The strongest signal at this locus was represented by a SNP in intron 3, rs17674580, that reached genome-wide significance in the overall analysis of the discovery and follow-up groups: odds ratio = 1.17, P = 7.6 × 10(-11). SLC14A1 codes for UTs that define the Kidd blood group and are crucial for the maintenance of a constant urea concentration gradient in the renal medulla and, through this, the kidney's ability to concentrate urine. It is speculated that rs17674580, or other sequence variants in LD with it, indirectly modifies UBC risk by affecting urine production. If confirmed, this would support the 'urogenous contact hypothesis' that urine production and voiding frequency modify the risk of UBC. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
700 | 1 | a Vermeulen, Sita H4 aut |
700 | 1 | a Sulem, Patrick4 aut |
700 | 1 | a Thorleifsson, Gudmar4 aut |
700 | 1 | a Aben, Katja K4 aut |
700 | 1 | a Witjes, J Alfred4 aut |
700 | 1 | a Grotenhuis, Anne J4 aut |
700 | 1 | a Verhaegh, Gerald W4 aut |
700 | 1 | a Hulsbergen-van de Kaa, Christina A4 aut |
700 | 1 | a Besenbacher, Soren4 aut |
700 | 1 | a Gudbjartsson, Daniel4 aut |
700 | 1 | a Stacey, Simon N4 aut |
700 | 1 | a Gudmundsson, Julius4 aut |
700 | 1 | a Johannsdottir, Hrefna4 aut |
700 | 1 | a Bjarnason, Hjordis4 aut |
700 | 1 | a Zanon, Carlo4 aut |
700 | 1 | a Helgadottir, Hafdis4 aut |
700 | 1 | a Jonasson, Jon Gunnlaugur4 aut |
700 | 1 | a Tryggvadottir, Laufey4 aut |
700 | 1 | a Jonsson, Eirikur4 aut |
700 | 1 | a Geirsson, Gudmunduru Karolinska Institutet4 aut |
700 | 1 | a Nikulasson, Sigfus4 aut |
700 | 1 | a Petursdottir, Vigdis4 aut |
700 | 1 | a Bishop, D Timothy4 aut |
700 | 1 | a Chung-Sak, Sei4 aut |
700 | 1 | a Choudhury, Ananya4 aut |
700 | 1 | a Elliott, Faye4 aut |
700 | 1 | a Barrett, Jennifer H4 aut |
700 | 1 | a Knowles, Margaret A4 aut |
700 | 1 | a de Verdier, Petra Ju Karolinska Institutet4 aut |
700 | 1 | a Ryk, Charlottau Karolinska Institutet4 aut |
700 | 1 | a Lindblom, Annikau Karolinska Institutet4 aut |
700 | 1 | a Rudnai, Peter4 aut |
700 | 1 | a Gurzau, Eugene4 aut |
700 | 1 | a Koppova, Kvetoslava4 aut |
700 | 1 | a Vineis, Paolo4 aut |
700 | 1 | a Polidoro, Silvia4 aut |
700 | 1 | a Guarrera, Simonetta4 aut |
700 | 1 | a Sacerdote, Carlotta4 aut |
700 | 1 | a Panadero, Angeles4 aut |
700 | 1 | a Sanz-Velez, José I4 aut |
700 | 1 | a Sanchez, Manuel4 aut |
700 | 1 | a Valdivia, Gabriel4 aut |
700 | 1 | a Garcia-Prats, Maria D4 aut |
700 | 1 | a Hengstler, Jan G4 aut |
700 | 1 | a Selinski, Silvia4 aut |
700 | 1 | a Gerullis, Holger4 aut |
700 | 1 | a Ovsiannikov, Daniel4 aut |
700 | 1 | a Khezri, Abdolaziz4 aut |
700 | 1 | a Aminsharifi, Alireza4 aut |
700 | 1 | a Malekzadeh, Mahyar4 aut |
700 | 1 | a van den Berg, Leonard H4 aut |
700 | 1 | a Ophoff, Roel A4 aut |
700 | 1 | a Veldink, Jan H4 aut |
700 | 1 | a Zeegers, Maurice P4 aut |
700 | 1 | a Kellen, Eliane4 aut |
700 | 1 | a Fostinelli, Jacopo4 aut |
700 | 1 | a Andreoli, Daniele4 aut |
700 | 1 | a Arici, Cecilia4 aut |
700 | 1 | a Porru, Stefano4 aut |
700 | 1 | a Buntinx, Frank4 aut |
700 | 1 | a Ghaderi, Abbas4 aut |
700 | 1 | a Golka, Klaus4 aut |
700 | 1 | a Mayordomo, José I4 aut |
700 | 1 | a Matullo, Giuseppe4 aut |
700 | 1 | a Kumar, Rajiv4 aut |
700 | 1 | a Steineck, Gunnar,d 1952u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology4 aut0 (Swepub:gu)xstegu |
700 | 1 | a Kiltie, Anne E4 aut |
700 | 1 | a Kong, Augustine4 aut |
700 | 1 | a Thorsteinsdottir, Unnur4 aut |
700 | 1 | a Stefansson, Kari4 aut |
700 | 1 | a Kiemeney, Lambertus A4 aut |
710 | 2 | a Karolinska Institutetb Institutionen för kliniska vetenskaper, Avdelningen för onkologi4 org |
773 | 0 | t Human molecular geneticsd : Oxford University Press (OUP)g 20:21, s. 4268-81q 20:21<4268-81x 1460-2083x 0964-6906 |
856 | 4 | u https://academic.oup.com/hmg/article-pdf/20/21/4268/17252644/ddr303.pdf |
856 | 4 8 | u https://gup.ub.gu.se/publication/147916 |
856 | 4 8 | u https://doi.org/10.1093/hmg/ddr303 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:123341199 |
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