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Apoptin, a tumor-se...
Apoptin, a tumor-selective killer
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- Los, Marek Jan (författare)
- Interfaculty Institute for Biochemistry, University of Tübingen, Germany; BioApplications Enterprises, Winnipeg, MB, Canada
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- Panigrahi, Soumya (författare)
- Department of Immunology, Lerner Research Institute, Cleveland, USA
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- Rashedi, Iran (författare)
- Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Canada
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- Mandal, Sanat (författare)
- Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada
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- Stetefeld, Joerg (författare)
- Department of Chemistry, University of Manitoba, Winnipeg, Canada
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- Essmann, Frank (författare)
- Interfaculty Institute for Biochemistry, University of Tübingen, Tübingen, Germany
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- Schulze-Osthoff, Klaus (författare)
- Interfaculty Institute for Biochemistry, University of Tübingen, Tübingen, Germany
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(creator_code:org_t)
- Elsevier BV, 2009
- 2009
- Engelska.
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Ingår i: Biochimica et Biophysica Acta. Molecular Cell Research. - : Elsevier BV. - 0167-4889 .- 1879-2596. ; 1793:8, s. 1335-1342
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https://liu.diva-por... (primary) (Raw object)
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Apoptin, a small protein from chicken anemia virus, has attracted great attention, because it specifically kills tumor cells while leaving normal cells unharmed. The subcellular localization of apoptin appears to be crucial for this tumor-selective activity. In normal cells, apoptin resides in the cytoplasm, whereas in cancerous cells it translocates into the nucleus. The nuclear translocation of apoptin is largely controlled by its phosphorylation. In tumor cells, apoptin causes the nuclear accumulation of survival kinases including Akt and is phosphorylated by CDK2. Thereby, apoptin redirects survival signals into cell death responses. Apoptin also binds as a multimeric complex to DNA and interacts with several nuclear targets, such as the anaphase-promoting complex, resulting in a G2/M phase arrest. The proapoptotic signal of apoptin is then transduced from the nucleus to cytoplasm by Nur77, which triggers a p53-independent mitochondrial death pathway. In this review, we summarize recent discoveries of apoptin's mechanism of action that might provide intriguing insights for the development of novel tumor-selective anticancer drugs.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Nyckelord
- Apoptin; Apoptosis; CDK2; Nur77; Tumor
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