Apoptin, a tumor-selective killer

Los, Marek JanInterfaculty Institute for Biochemistry, University of Tübingen, Germany; BioApplications Enterprises, Winnipeg, MB, Canada (författare)

Invited Review
Apoptin, a small protein from chicken anemia virus, has attracted great attention, because it specifically kills tumor cells while leaving normal cells unharmed. The subcellular localization of apoptin appears to be crucial for this tumor-selective activity. In normal cells, apoptin resides in the cytoplasm, whereas in cancerous cells it translocates into the nucleus. The nuclear translocation of apoptin is largely controlled by its phosphorylation. In tumor cells, apoptin causes the nuclear accumulation of survival kinases including Akt and is phosphorylated by CDK2. Thereby, apoptin redirects survival signals into cell death responses. Apoptin also binds as a multimeric complex to DNA and interacts with several nuclear targets, such as the anaphase-promoting complex, resulting in a G2/M phase arrest. The proapoptotic signal of apoptin is then transduced from the nucleus to cytoplasm by Nur77, which triggers a p53-independent mitochondrial death pathway. In this review, we summarize recent discoveries of apoptin's mechanism of action that might provide intriguing insights for the development of novel tumor-selective anticancer drugs.

Panigrahi, SoumyaDepartment of Immunology, Lerner Research Institute, Cleveland, USA (författare)
Rashedi, IranInstitute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Canada (författare)
Mandal, SanatFaculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada (författare)
Stetefeld, JoergDepartment of Chemistry, University of Manitoba, Winnipeg, Canada (författare)
Essmann, FrankInterfaculty Institute for Biochemistry, University of Tübingen, Tübingen, Germany (författare)
Schulze-Osthoff, KlausInterfaculty Institute for Biochemistry, University of Tübingen, Tübingen, Germany (författare)
Interfaculty Institute for Biochemistry, University of Tübingen, Germany; BioApplications Enterprises, Winnipeg, MB, CanadaDepartment of Immunology, Lerner Research Institute, Cleveland, USA (creator_code:org_t)

Ingår i:Biochimica et Biophysica Acta. Molecular Cell Research: Elsevier BV1793:8, s. 1335-13420167-48891879-2596

Av författaren/redakt...: Los, Marek Jan; Panigrahi, Soumy ...; Rashedi, Iran; Mandal, Sanat; Stetefeld, Joerg; Essmann, Frank; visa fler...; Schulze-Osthoff, ...; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinsk biotek ...; och Medicinsk biotek ...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.