WFRF:(Stradner Anna)
Sökning: WFRF:(Stradner Anna) > Dramatic influence ...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04646naa a2200433 4500 | |
| 001 | oai:lup.lub.lu.se:fefd8e86-f4f6-43dc-b416-cbfc1b9b8735 | |
| 003 | SwePub | |
| 008 | 170315s2016 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/fefd8e86-f4f6-43dc-b416-cbfc1b9b87352 URI |
| 024 | 7 | a https://doi.org/10.1126/sciadv.16014322 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Bucciarelli, Saskiau Lund University,Lunds universitet,Fysikalisk kemi,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Physical Chemistry,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)fkem-sbi |
| 245 | 1 0 | a Dramatic influence of patchy attractions on short-time protein diffusion under crowded conditions |
| 264 | 1 | b American Association for the Advancement of Science (AAAS),c 2016 |
| 300 | a 9 s. | |
| 520 | a In the dense and crowded environment of the cell cytoplasm, an individual protein feels the presence of and interacts with all surrounding proteins. While we expect this to strongly influence the short-time diffusion coefficient Ds of proteins on length scales comparable to the nearest-neighbor distance, this quantity is difficult to assess experimentally. We demonstrate that quantitative information about Ds can be obtained from quasi-elastic neutron scattering experiments using the neutron spin echo technique. We choose two well-characterized and highly stable eye lens proteins, bovine α-crystallin and γB-crystallin, and measure their diffusion at concentrations comparable to those present in the eye lens. While diffusion slows down with increasing concentration for both proteins, we find marked variations that are directly linked to subtle differences in their interaction potentials. A comparison with computer simulations shows that anisotropic and patchy interactions play an essential role in determining the local short-time dynamics. Hence, our study clearly demonstrates the enormous effect that weak attractions can have on the short-time diffusion of proteins at concentrations comparable to those in the cellular cytosol. | |
| 650 | 7 | a NATURVETENSKAPx Biologix Biofysik0 (SwePub)106032 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biophysics0 (SwePub)106032 hsv//eng |
| 650 | 7 | a NATURVETENSKAPx Kemix Fysikalisk kemi0 (SwePub)104022 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Chemical Sciencesx Physical Chemistry0 (SwePub)104022 hsv//eng |
| 700 | 1 | a Myung, Jin Suku Lund University,Lunds universitet,Fysikalisk kemi,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Physical Chemistry,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,Jülich Research Centre4 aut0 (Swepub:lu)ji8662my |
| 700 | 1 | a Farago, Belau Institut Laue Langevin4 aut |
| 700 | 1 | a Das, Shibanandau Jülich Research Centre4 aut |
| 700 | 1 | a Vliegenthart, Gerard Au Jülich Research Centre4 aut |
| 700 | 1 | a Holderer, Olafu Jülich Research Centre4 aut |
| 700 | 1 | a Winkler, Roland G.u Jülich Research Centre4 aut |
| 700 | 1 | a Schurtenberger, Peteru Lund University,Lunds universitet,Fysikalisk kemi,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Physical Chemistry,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)fkem-psh |
| 700 | 1 | a Gompper, Gerhardu Jülich Research Centre4 aut |
| 700 | 1 | a Stradner, Annau Lund University,Lunds universitet,Fysikalisk kemi,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Physical Chemistry,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,University of Fribourg4 aut0 (Swepub:lu)fkem-aas |
| 710 | 2 | a Fysikalisk kemib Enheten för fysikalisk och teoretisk kemi4 org |
| 773 | 0 | t Science Advancesd : American Association for the Advancement of Science (AAAS)g 2:12, s. 1601432-1601432q 2:12<1601432-1601432x 2375-2548 |
| 856 | 4 | u http://dx.doi.org/10.1126/sciadv.1601432x freey FULLTEXT |
| 856 | 4 | u https://advances.sciencemag.org/content/advances/2/12/e1601432.full.pdf |
| 856 | 4 8 | u https://lup.lub.lu.se/record/fefd8e86-f4f6-43dc-b416-cbfc1b9b8735 |
| 856 | 4 8 | u https://doi.org/10.1126/sciadv.1601432 |
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