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Sökning: WFRF:(Sullivan Patrick F) > (2005-2009) > Gene expression in ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003592naa a2200409 4500
001oai:DiVA.org:umu-27082
003SwePub
008091110s2009 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:119834493
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-270822 URI
0247 a https://doi.org/10.1371/journal.pone.00058052 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1198344932 URI
040 a (SwePub)umud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Byrnes, Andreau Dept Genetics and dept Biostatistics, University of North Carolina4 aut
2451 0a Gene expression in peripheral blood leukocytes in monozygotic twins discordant for chronic fatigue :b no evidence of a biomarker
264 c 2009-06-05
264 1b Public Library of Science (PLoS),c 2009
338 a print2 rdacarrier
520 a BACKGROUND: Chronic fatiguing illness remains a poorly understood syndrome of unknown pathogenesis. We attempted to identify biomarkers for chronic fatiguing illness using microarrays to query the transcriptome in peripheral blood leukocytes. METHODS: Cases were 44 individuals who were clinically evaluated and found to meet standard international criteria for chronic fatigue syndrome or idiopathic chronic fatigue, and controls were their monozygotic co-twins who were clinically evaluated and never had even one month of impairing fatigue. Biological sampling conditions were standardized and RNA stabilizing media were used. These methodological features provide rigorous control for bias resulting from case-control mismatched ancestry and experimental error. Individual gene expression profiles were assessed using Affymetrix Human Genome U133 Plus 2.0 arrays. FINDINGS: There were no significant differences in gene expression for any transcript. CONCLUSIONS: Contrary to our expectations, we were unable to identify a biomarker for chronic fatiguing illness in the transcriptome of peripheral blood leukocytes suggesting that positive findings in prior studies may have resulted from experimental bias.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Medicinsk bioteknologi0 (SwePub)304012 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Medical Biotechnology0 (SwePub)304012 hsv//eng
7001 a Jacks, Andreasu Dept Medical Epidemiology and Biostatistics, Karolinska Institutet4 aut
7001 a Dahlman-Wright, Karinu Karolinska Institutet4 aut
7001 a Evengård, Birgitta,d 1952-u Umeå universitet,Infektionssjukdomar4 aut0 (Swepub:umu)biev0002
7001 a Wright, Fred Au Dept Biostatistics, University of North Carolina4 aut
7001 a Pedersen, Nancy Lu Dept Medical Epidemiology and Biostatistis, Karolinska Institutet4 aut
7001 a Sullivan, Patrick Fu Dept Genetics, Univ of North Carolina, Dept Medical Epid and Biostat, Karol Institutet4 aut
7102 a Dept Genetics and dept Biostatistics, University of North Carolinab Dept Medical Epidemiology and Biostatistics, Karolinska Institutet4 org
7730 t PLOS ONEd : Public Library of Science (PLoS)g 4:6, s. e5805-q 4:6<e5805-x 1932-6203
8564 u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0005805&type=printable
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-27082
8564 8u https://doi.org/10.1371/journal.pone.0005805
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:119834493

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