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Splanchnic balance ...
Splanchnic balance of free fatty acids, endocannabinoids, and lipids in subjects with nonalcoholic fatty liver disease
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- Westerbacka, Jukka (author)
- Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland
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- Kotronen, Anna (author)
- Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland: Minerva Medical Research Institute, Helsinki, Finland; Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland
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- Fielding, Barbara A. (author)
- Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom
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- Wahren, John (author)
- Karolinska Institutet
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- Hodson, Leanne (author)
- Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom
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- Perttilä, Julia (author)
- Minerva Medical Research Institute, Helsinki, Finland
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- Seppänen-Laakso, Tuulikki (author)
- VTT Technical Research Centre of Finland, Espoo, Finland
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- Suortti, Tapani (author)
- VTT Technical Research Centre of Finland, Espoo, Finland
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- Arola, Johanna (author)
- Department of Pathology, University of Helsinki and HUSLAB, Helsinki, Finland
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- Hultcrantz, Rolf (author)
- Karolinska Institutet
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- Castillo, Sandra (author)
- VTT Technical Research Centre of Finland, Espoo, Finland
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- Olkkonen, Vesa M. (author)
- Minerva Medical Research Institute, Helsinki, Finland
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- Frayn, Keith N. (author)
- Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom
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- Oresic, Matej, 1967- (author)
- VTT Technical Research Centre of Finland, Espoo, Finland
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- Yki-Järvinen, Hannele (author)
- Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland
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(creator_code:org_t)
- Saunders Elsevier, 2010
- 2010
- English.
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In: Gastroenterology. - : Saunders Elsevier. - 0016-5085 .- 1528-0012. ; 139:6, s. 1961-1971.e1
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND & AIMS: Animal studies suggest that endocannabinoids could contribute to the development of nonalcoholic fatty liver disease (NAFLD). In addition, NAFLD has been shown to be associated with multiple changes in lipid concentrations in liver biopsies. There are no data on splanchnic free fatty acid (FFA), glycerol, ketone body, endocannabinoid, and lipid fluxes in vivo in subjects with NAFLD.METHODS: We performed hepatic venous catheterization studies in combination with [(2)H(2)]palmitate infusion in the fasting state and during a low-dose insulin infusion in 9 subjects with various degrees of hepatic steatosis as determined using liver biopsy. Splanchnic balance of endocannabinoids and individual lipids was determined using ultra performance liquid chromatography coupled to mass spectrometry.RESULTS: Concentrations of the endocannabinoid 2-arachidonoylglycerol were higher in arterialized (91 ± 33 μg/L basally) than in hepatic venous (51 ± 19 μg/L; P < .05) plasma. Fasting arterial (r = 0.72; P = .031) and hepatic venous (r = 0.70; P = .037) concentrations of 2-arachidonoylglycerol were related positively to liver fat content. Analysis of fluxes of 85 different triglycerides showed that the fatty liver overproduces saturated triglycerides. In the plasma FFA fraction in the basal state, the relative amounts of palmitoleate and linoleate were lower and those of stearate and oleate were higher in the hepatic vein than in the artery. Absolute concentrations of all nontriglyceride lipids were comparable in arterialized venous plasma and the hepatic vein both in the basal and insulin-stimulated states.CONCLUSIONS: The human fatty liver takes up 2-arachidonoylglycerol and overproduces triacylglycerols containing saturated fatty acids, which might reflect increased de novo lipogenesis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Westerbacka, Juk ...
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Kotronen, Anna
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Fielding, Barbar ...
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Wahren, John
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Hodson, Leanne
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Perttilä, Julia
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Seppänen-Laakso, ...
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Suortti, Tapani
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Arola, Johanna
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Hultcrantz, Rolf
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Castillo, Sandra
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Olkkonen, Vesa M ...
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Frayn, Keith N.
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Oresic, Matej, 1 ...
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Yki-Järvinen, Ha ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Gastroenterology ...
- Articles in the publication
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Gastroenterology
- By the university
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Örebro University
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Karolinska Institutet