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Sökning: WFRF:(Sveinsdóttir Snjólaug) > High presence of ex...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006604naa a2200517 4500
001oai:lup.lub.lu.se:299fa399-f3ca-4199-81a4-bb57b6e0d772
003SwePub
008161102s2016 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/299fa399-f3ca-4199-81a4-bb57b6e0d7722 URI
0247 a https://doi.org/10.3389/fphys.2016.003302 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Ley, Davidu Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)pedi-dle
2451 0a High presence of extracellular hemoglobin in the periventricular white matter following preterm intraventricular hemorrhage
264 c 2016-08-03
264 1b Frontiers Media SA,c 2016
520 a Severe cerebral intraventricular hemorrhage (IVH) in preterm infants continues to be a major clinical problem, occurring in about 15-20% of very preterm infants. In contrast to other brain lesions the incidence of IVH has not been reduced over the last decade, but actually slightly increased. Currently over 50% of surviving infants develop post-hemorrhagic ventricular dilatation and about 35% develop severe neurological impairment, mainly cerebral palsy and intellectual disability. To date there is no therapy available to prevent infants from developing either hydrocephalus or serious neurological disability. It is known that blood rapidly accumulates within the ventricles following IVH and this leads to disruption of normal anatomy and increased local pressure. However, the molecular mechanisms causing brain injury following IVH are incompletely understood. We propose that extracellular hemoglobin is central in the pathophysiology of periventricular white matter damage following IVH. Using a preterm rabbit pup model of IVH the distribution of extracellular hemoglobin was characterized at 72 h following hemorrhage. Evaluation of histology, histochemistry, hemoglobin immunolabeling and scanning electron microscopy revealed presence of extensive amounts of extracellular hemoglobin, i.e., not retained within erythrocytes, in the periventricular white matter, widely distributed throughout the brain. Furthermore, double immunolabeling together with the migration and differentiation markers polysialic acid neural cell adhesion molecule (PSA-NCAM) demonstrates that a significant proportion of the extracellular hemoglobin is distributed in areas of the periventricular white matter with high extracellular plasticity. In conclusion, these findings support that extracellular hemoglobin may contribute to the pathophysiological processes that cause irreversible damage to the immature brain following IVH.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng
653 a Hemoglobin
653 a Imaging
653 a Immature brain
653 a Intraventricular hemorrhage
653 a Periventricular white matter
653 a Peroxidase activity
653 a Plasticity
7001 a Romantsik, Olgau Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)med-oar
7001 a Vallius, Suviu Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)med-svv
7001 a Sveinsdóttir, Kristbjörgu Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)med-kbs
7001 a Sveinsdóttir, Snjolaugu Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)med-sus
7001 a Agyemang, Alex A.u Lund University,Lunds universitet,Neonatalogi,Forskargrupper vid Lunds universitet,Neonatology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-aua
7001 a Baumgarten, Mariau Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)medk-mba
7001 a Mörgelin, Matthiasu Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)medk-mmn
7001 a Lutay, Nataliyau ImaGene-iT AB4 aut0 (Swepub:lu)med-nll
7001 a Bruschettini, Matteou Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)med-mb14
7001 a Holmqvist, Bou ImaGene-iT AB4 aut0 (Swepub:lu)zool-bho
7001 a Gram, Magnusu Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)medk-mo0
7102 a Pediatrik, Lundb Sektion V4 org
7730 t Frontiers in Physiologyd : Frontiers Media SAg 7:AUGq 7:AUGx 1664-042X
8564 u http://dx.doi.org/10.3389/fphys.2016.00330x freey FULLTEXT
8564 u https://www.frontiersin.org/articles/10.3389/fphys.2016.00330/pdf
8564 8u https://lup.lub.lu.se/record/299fa399-f3ca-4199-81a4-bb57b6e0d772
8564 8u https://doi.org/10.3389/fphys.2016.00330

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