SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Szwajcer E)
 

Sökning: WFRF:(Szwajcer E) > The Impact of Donor...

  • Arnold, Staci D.Emory Univ, Childrens Healthcare Atlanta, Aflac Canc & Blood Disorder Ctr, Atlanta, GA 30322 USA. (författare)

The Impact of Donor Type on Outcomes and Cost of Allogeneic Hematopoietic Cell Transplantation for Pediatric Leukemia : A Merged Center for International Blood and Marrow Transplant Research and Pediatric Health Information System Analysis

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • Elsevier BV,2020
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-423278
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-423278URI
  • https://doi.org/10.1016/j.bbmt.2020.05.016DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:144796448URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Allogeneic hematopoietic stem cell transplantation (alloHCT) may be associated with significant morbidity and mortality, resulting in increased healthcare utilization (HCU). To date, no multicenter comparative cost analyses have specifically evaluated alloHCT in children with acute leukemia. In this retrospective cohort study, we examined the relationship between survival and HCU while investigating the hypothesis that matched sibling donor (MSD) alloHCT has significantly lower inpatient HCU with unrelated donor (URD) alloHCT, and that among URDs, umbilical cord blood (UCB) alloHCT will have higher initial utilization but lower long-term utilization. Clinical and transplantation outcomes data from the Center for International Blood and Marrow Transplant Research (CIBMTR) were merged with inpatient cost data from the Pediatric Health Information System (PHIS) database using a probabilistic merge methodology. The merged dataset comprised US patients age 1 to 21 years who underwent alloHCT for acute leukemia between 2004 and 2011 with comprehensive CIBMTR data at a PHIS hospital. AlloHCT was analyzed by donor type, with specific analysis of utilization and costs using PHIS claims data. The primary outcomes of overall survival (OS), leukemia-free survival (LFS), and inpatient costs were evaluated using Kaplan-Meier curves and Cox and Poisson models. A total of 632 patients were identified in both the CIBMTR and PHIS data. The 5-year LFS was 60% for MSD alloHCT, 47% for well-matched matched unrelated donor bone marrow (MUD) alloHCT, 48% for mismatched unrelated donor alloHCT, and 45% for UCB alloHCT (P = .09). Total adjusted costs were significantly lower for MSD alloHCT versus MUD alloHCT by day 100 (adjusted cost ratio [ACR], .73; 95% confidence interval [CI], .62 to .86; P < .001), and higher for UCB alloHCT versus MUD alloHCT (ACR, 1.27; 95% CI, 1.11 to 1.45; P < .001). By 2 years, total adjusted costs remained significantly lower for MSD alloHCT compared with MUD alloHCT (ACR, .67; 95% CI, .56 to .81; P < .001) and higher for UCB alloHCT compared with MUD alloHCT (ACR, 1.25; 95% CI, 1.02 to 1.52; P = .0280). Our data show that UCB and MUD alloHCT provide similar survival outcomes; however, MUD alloHCT has a significant advantage in cost by day 100 and 2 years. More research is needed to determine whether the cost difference among URD alloHCT approaches remains significant with a larger sample size and/or beyond 2 years post-alloHCT.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Brazauskas, RutaMed Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Equ, Div Biostat, Milwaukee, WI 53226 USA. (författare)
  • He, NayaMed Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA. (författare)
  • Li, YimeiUniv Penn, Dept Biostat Epidemiol & Informat, Philadelphia, PA 19104 USA. (författare)
  • Hall, MattChildrens Hosp Assoc, Mission, KS USA. (författare)
  • Atsuta, YoshikoJapanese Data Ctr Hematopoiet Cell Transplantat, Nagoya, Aichi, Japan.;Nagoya Univ, Grad Sch Med, Dept Biostat Epidemiol & Informat, Nagoya, Aichi, Japan. (författare)
  • Dalal, JigneshRainbow Babies & Childrens Hosp, Dept Biostat Epidemiol & Informat, 2101 Adelbert Rd, Cleveland, OH 44106 USA. (författare)
  • Hahn, TheresaRoswell Pk Canc Inst, Dept Med, Buffalo, NY USA. (författare)
  • Khera, NanditaMayo Clin, Dept Hematol Oncol, Phoenix, AZ USA. (författare)
  • Bonfim, CarmemUniv Fed Parana, Hosp Clin, Dept Biostat Epidemiol & Informat, Curitiba, Parana, Brazil. (författare)
  • Hashmi, ShahrukhKing Faisal Specialist Hosp & Res Ctr, Oncol Ctr, Riydah, Saudi Arabia.;Mayo Clin, Dept Internal Med, Rochester, MN USA. (författare)
  • Parsons, SusanTufts Med Ctr, Dept Biostat Epidemiol & Informat, Boston, MA 02111 USA. (författare)
  • Wood, William A.Univ N Carolina, Dept Med, Div Hematol & Oncol, Chapel Hill, NC 27515 USA. (författare)
  • Steinberg, AmirMt Saini Hosp, Div Hematol & Oncol, New York, NY USA. (författare)
  • Freytes, Cesar O.Texas Transplant Inst, San Antonio, TX USA. (författare)
  • Dandoy, Christopher E.Univ Cincinnati, Sch Med, Cincinnati Childrens Hosp Med Ctr, Dept Biostat Epidemiol & Informat, Cincinnati, OH USA. (författare)
  • Marks, David, IUniv Hosp Bristol NHS Trust, Adult Bone Marrow Transplant, Bristol, Avon, England. (författare)
  • Lazarus, Hillard M.Case Western Reserve Univ, Univ Hosp Cleveland Med Ctr, Dept Biostat Epidemiol & Informat, Cleveland, OH 44106 USA. (författare)
  • Abdel-Azim, HishamUniv Southern Calif, Keck Sch Med, Childrens Hosp Los Angeles, Div Hematol Oncol & Blood & Marrow Transplantat, Los Angeles, CA 90007 USA. (författare)
  • Bitan, MenachemTel Aviv Sourasky Med Ctr, Dept Pediat Hematol Oncol, Tel Aviv, Israel. (författare)
  • Diaz, Miguel AngelHosp Infantil Univ Nino Jesus, Dept Hematol Oncol, Madrid, Spain. (författare)
  • Olsson, Richard F.Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Stockholm, Sweden(Swepub:uu)riols677 (författare)
  • Gergis, UsamaThomas Jefferson Univ, Div Hematol Malignancies, Dept Med Oncol, Philadelphia, PA 19107 USA. (författare)
  • Seber, AdrianaHosp Samaritano Sao Paulo, Dept Biostat Epidemiol & Informat, Sao Paulo, Brazil. (författare)
  • Wirk, BaldeepPenn State Canc Inst, Bone Marrow Transplant Program, Hershey, PA USA. (författare)
  • LeMaistre, C. FredSarah Cannon Blood Canc Network, Nashville, TN USA. (författare)
  • Ustun, CelalettinRush Univ, Div Hematol Oncol Cell Therapy, Chicago, IL 60612 USA. (författare)
  • Duncan, ChristineBoston Childrens Hosp, Dept Pediat Oncol, Boston, MA USA.;Dana Farber Canc Inst, Boston, MA 02115 USA. (författare)
  • Rizzieri, DavidDuke Univ, Div Hematol Malignancies & Cellular Therapy, Durham, NC USA. (författare)
  • Szwajcer, DavidUniv Manitoba, Canc Care Manitoba, Winnipeg, MB, Canada. (författare)
  • Fagioli, FrancaRegina Margherita Children Hosp, City Sci & Hlth Turin, Stem Cell Transplantat & Cell Therapy Div, Pediat Oncohematol, Turin, Italy. (författare)
  • Frangoul, HaydarChildrens Hosp TriStar Centennial Med Ctr, Dept Biostat Epidemiol & Informat, Nashville, TN USA.;Sarah Cannon Res Inst, Nashville, TN USA. (författare)
  • Knight, Jennifer M.Med Coll Wisconsin, Dept Psychiat, Milwaukee, WI 53226 USA. (författare)
  • Kamble, Rammurti T.Baylor Coll Med, Ctr Cell & Gene Therapy, Div Hematol & Oncol, Houston, TX 77030 USA. (författare)
  • Mehta, PauletteCent Arkansas Vet Healthcare Syst, Little Rock, AR USA.;Univ Arkansas Med Sci, Little Rock, AR 72205 USA. (författare)
  • Schears, RaquelUniv Cent Florida, Dept Emergency Med, Orlando, FL USA. (författare)
  • Satwani, PrakashColumbia Univ, Dept Pediat, Med Ctr, Div Pediat Hematol Oncol & Stem Cell Transplantat, New York, NY 10027 USA. (författare)
  • Pulsipher, Michael A.Univ Southern Calif, Canc & Blood Dis Inst, Childrens Hosp Los Angeles, Sect Transplantat & Cellular Therapy,Keck Sch Med, Los Angeles, CA 90007 USA. (författare)
  • Aplenc, RichardUniv Penn, Dept Biostat Epidemiol & Informat, Philadelphia, PA 19104 USA. (författare)
  • Saber, WaelMed Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA. (författare)
  • Emory Univ, Childrens Healthcare Atlanta, Aflac Canc & Blood Disorder Ctr, Atlanta, GA 30322 USA.Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Equ, Div Biostat, Milwaukee, WI 53226 USA. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Biology of blood and marrow transplantation: Elsevier BV26:9, s. 1747-17561083-87911523-6536

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy