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Factors associated ...
Factors associated with experience of fatigue, and functional limitations due to fatigue in patients with stable COPD
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- Kentson, Magnus (författare)
- Linköpings universitet,Institutionen för medicin och hälsa,Medicinska fakulteten,Ryhov County Hospital, Sweden
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- Tödt, Kristina, 1966- (författare)
- Linköpings universitet,Medicinska fakulteten,Avdelningen för fysioterapi,Skåne University Hospital, Sweden
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- Skargren, Elisabeth (författare)
- Linköpings universitet,Medicinska fakulteten,Institutionen för medicin och hälsa
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- Jakobsson, Per (författare)
- Ryhov Cty Hosp, Dept Med, Div Pulmonol, S-55185 Jonkoping, Sweden.,Ryhov County Hospital, Sweden
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- Ernerudh, Jan (författare)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Klinisk immunologi och transfusionsmedicin
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- Unosson, Mitra (författare)
- Linköpings universitet,Avdelningen för omvårdnad,Medicinska fakulteten
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- Theander, Kersti, 1956- (författare)
- Karlstads universitet,Institutionen för hälsovetenskaper (from 2013),Karlstads universitet, Institutionen för hälsovetenskaper (from 2013),Karlstad University, Sweden; County Council Varmland, Sweden
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(creator_code:org_t)
- 2016-09-19
- 2016
- Engelska.
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Ingår i: Therapeutic Advances in Respiratory Disease. - : Sage Publications. - 1753-4658 .- 1753-4666. ; 10:5, s. 410-424
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Abstract
Ämnesord
Stäng
- Background: The aim of this study was to determine the influence of selected physiological, psychological and situational factors on experience of fatigue, and functional limitations due to fatigue in patients with stable chronic obstructive pulmonary disease (COPD). Methods: In total 101 patients with COPD and 34 control patients were assessed for experience of fatigue, functional limitation due to fatigue (Fatigue Impact Scale), physiological [lung function, 6-minute walk distance (6MWD), body mass index (BMI), dyspnoea, interleukin (IL)-6, IL-8, high sensitivity C-reactive protein (hs-CRP), surfactant protein D], psychological (anxiety, depression, insomnia), situational variables (age, sex, smoking, living alone, education), and quality of life. Results: Fatigue was more common in patients with COPD than in control patients (72% versus 56%, p < 0.001). Patients with COPD and fatigue had lower lung function, shorter 6MWD, more dyspnoea, anxiety and depressive symptoms, and worse health status compared with patients without fatigue (all p < 0.01). No differences were found for markers of systemic inflammation. In logistic regression, experience of fatigue was associated with depression [odds ratio (OR) 1.69, 95% confidence interval (CI) 1.28-2.25) and insomnia (OR 1.75, 95% CI 1.19-2.54). In linear regression models, depression, surfactant protein D and dyspnoea explained 35% (R-2) of the variation in physical impact of fatigue. Current smoking and depression explained 33% (R-2) of the cognitive impact of fatigue. Depression and surfactant protein D explained 48% (R-2) of the psychosocial impact of fatigue. Conclusions: Experiences of fatigue and functional limitation due to fatigue seem to be related mainly to psychological but also to physiological influencing factors, with depressive symptoms, insomnia problems and dyspnoea as the most prominent factors. Systemic inflammation was not associated with perception of fatigue but surfactant protein D was connected to some dimensions of the impact of fatigue
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Omvårdnad (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nursing (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- chronic obstructive pulmonary disease
- fatigue
- symptoms
- systemic inflammation
- Nursing Science
- Omvårdnad
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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