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  • Malapelle, UmbertoUniversity of Naples Federico II (author)

Predictive molecular pathology in the time of coronavirus disease (COVID-19) in Europe

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2020-07-31
  • BMJ,2021
  • 5 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:38cadbef-5a6d-4580-9c1d-1bcda92282df
  • https://lup.lub.lu.se/record/38cadbef-5a6d-4580-9c1d-1bcda92282dfURI
  • https://doi.org/10.1136/jclinpath-2020-206957DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Aims Lung cancer predictive biomarker testing is essential to select advanced-stage patients for targeted treatments and should be carried out without delays even during health emergencies, such as the coronavirus (COVID-19) outbreak. Methods Fifteen molecular laboratories from seven different European countries compared 4 weeks of national lockdown to a corresponding period in 2019, in terms of tissue and/or plasma-based molecular test workload, analytical platforms adopted, number of cases undergoing programmed death-ligand1 (PD-L1) expression assessment and DNA-based molecular tests turnaround time. Results In most laboratories (80.0%), tissue-based molecular test workload was reduced. In 40.0% of laboratories (6/15), the decrease was >25%, and in one, reduction was as high as 80.0%. In this instance, a concomitant increase in liquid biopsy was reported (60.0%). Remarkably, in 33.3% of the laboratories, real-time PCR (RT-PCR)-based methodologies increased, whereas highly multiplexing assays approaches decreased. Most laboratories (88.9%) did not report significant variations in PD-L1 volume testing. Conclusions The workload of molecular testing for patients with advanced-stage lung cancer during the lockdown showed little variations. Local strategies to overcome health emergency-related issues included the preference for RT-PCR tissue-based testing methodologies and, occasionally, for liquid biopsy.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Pisapia, PasqualeUniversity of Naples Federico II (author)
  • Iaccarino, AntoninoUniversity of Naples Federico II (author)
  • Barberis, MassimoEuropean Institute of Oncology (author)
  • Bellevicine, ClaudioUniversity of Naples Federico II (author)
  • Brunnström, HansLund University,Lunds universitet,Patologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Pathology, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-hsb (author)
  • de Biase, DarioUniversity of Bologna (author)
  • de Maglio, GiovannaUniversity Hospital of Udine (author)
  • Lindquist, Kajsa EricsonLund University,Lunds universitet,Patologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Pathology, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-ker (author)
  • Fassan, MatteoUniversity of Padova (author)
  • Fontanini, GabriellaUniversity of Pisa (author)
  • Gruppioni, ElisaUniversity of Bologna (author)
  • Hofman, PaulInstitut Gustave Roussy (author)
  • Merkelbach-Bruse, SabineUniversity Hospital of Cologne (author)
  • Molina Vila, Miguel A.Pangaea Oncology (author)
  • Pujals, AnaïsHenri Mondor Hospital (author)
  • Rapa, IdaSan Luigi University Hospital (author)
  • Righi, LuisellaUniversity of Turin (author)
  • Rosell, RafaelHospital Universitari Germans Trias i Pujol (author)
  • Schildgen, OliverWitten/Herdecke University (author)
  • Schildgen, VerenaWitten/Herdecke University (author)
  • Schmitt, Fernando C.University of Porto (author)
  • Tallini, GiovanniUniversity of Bologna (author)
  • Borght, Sara VanderUniversity Hospitals Leuven (author)
  • Vigliar, ElenaUniversity of Naples Federico II (author)
  • Volante, MarcoUniversity of Turin (author)
  • Wagener-Ryczek, SvenjaUniversity Hospital of Cologne (author)
  • Weynand, BirgitUniversity Hospitals Leuven (author)
  • Troncone, GiancarloUniversity of Naples Federico II (author)
  • University of Naples Federico IIEuropean Institute of Oncology (creator_code:org_t)

Related titles

  • In:Journal of Clinical Pathology: BMJ74:6, s. 391-3950021-97461472-4146

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