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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005374naa a2200673 4500
001oai:lup.lub.lu.se:38cadbef-5a6d-4580-9c1d-1bcda92282df
003SwePub
008211118s2021 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/38cadbef-5a6d-4580-9c1d-1bcda92282df2 URI
0247 a https://doi.org/10.1136/jclinpath-2020-2069572 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Malapelle, Umbertou University of Naples Federico II4 aut
2451 0a Predictive molecular pathology in the time of coronavirus disease (COVID-19) in Europe
264 c 2020-07-31
264 1b BMJ,c 2021
300 a 5 s.
520 a Aims Lung cancer predictive biomarker testing is essential to select advanced-stage patients for targeted treatments and should be carried out without delays even during health emergencies, such as the coronavirus (COVID-19) outbreak. Methods Fifteen molecular laboratories from seven different European countries compared 4 weeks of national lockdown to a corresponding period in 2019, in terms of tissue and/or plasma-based molecular test workload, analytical platforms adopted, number of cases undergoing programmed death-ligand1 (PD-L1) expression assessment and DNA-based molecular tests turnaround time. Results In most laboratories (80.0%), tissue-based molecular test workload was reduced. In 40.0% of laboratories (6/15), the decrease was >25%, and in one, reduction was as high as 80.0%. In this instance, a concomitant increase in liquid biopsy was reported (60.0%). Remarkably, in 33.3% of the laboratories, real-time PCR (RT-PCR)-based methodologies increased, whereas highly multiplexing assays approaches decreased. Most laboratories (88.9%) did not report significant variations in PD-L1 volume testing. Conclusions The workload of molecular testing for patients with advanced-stage lung cancer during the lockdown showed little variations. Local strategies to overcome health emergency-related issues included the preference for RT-PCR tissue-based testing methodologies and, occasionally, for liquid biopsy.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng
7001 a Pisapia, Pasqualeu University of Naples Federico II4 aut
7001 a Iaccarino, Antoninou University of Naples Federico II4 aut
7001 a Barberis, Massimou European Institute of Oncology4 aut
7001 a Bellevicine, Claudiou University of Naples Federico II4 aut
7001 a Brunnström, Hansu Lund University,Lunds universitet,Patologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Pathology, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-hsb
7001 a de Biase, Dariou University of Bologna4 aut
7001 a de Maglio, Giovannau University Hospital of Udine4 aut
7001 a Lindquist, Kajsa Ericsonu Lund University,Lunds universitet,Patologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Pathology, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-ker
7001 a Fassan, Matteou University of Padova4 aut
7001 a Fontanini, Gabriellau University of Pisa4 aut
7001 a Gruppioni, Elisau University of Bologna4 aut
7001 a Hofman, Paulu Institut Gustave Roussy4 aut
7001 a Merkelbach-Bruse, Sabineu University Hospital of Cologne4 aut
7001 a Molina Vila, Miguel A.u Pangaea Oncology4 aut
7001 a Pujals, Anaïsu Henri Mondor Hospital4 aut
7001 a Rapa, Idau San Luigi University Hospital4 aut
7001 a Righi, Luisellau University of Turin4 aut
7001 a Rosell, Rafaelu Hospital Universitari Germans Trias i Pujol4 aut
7001 a Schildgen, Oliveru Witten/Herdecke University4 aut
7001 a Schildgen, Verenau Witten/Herdecke University4 aut
7001 a Schmitt, Fernando C.u University of Porto4 aut
7001 a Tallini, Giovanniu University of Bologna4 aut
7001 a Borght, Sara Vanderu University Hospitals Leuven4 aut
7001 a Vigliar, Elenau University of Naples Federico II4 aut
7001 a Volante, Marcou University of Turin4 aut
7001 a Wagener-Ryczek, Svenjau University Hospital of Cologne4 aut
7001 a Weynand, Birgitu University Hospitals Leuven4 aut
7001 a Troncone, Giancarlou University of Naples Federico II4 aut
7102 a University of Naples Federico IIb European Institute of Oncology4 org
7730 t Journal of Clinical Pathologyd : BMJg 74:6, s. 391-395q 74:6<391-395x 0021-9746x 1472-4146
8564 u http://dx.doi.org/10.1136/jclinpath-2020-206957y FULLTEXT
8564 u https://jcp.bmj.com/content/jclinpath/74/6/391.full.pdf
8564 8u https://lup.lub.lu.se/record/38cadbef-5a6d-4580-9c1d-1bcda92282df
8564 8u https://doi.org/10.1136/jclinpath-2020-206957

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