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Search: WFRF:(Thorleifsson Guðmar) > (2006-2009) > The T-381C SNP in B...

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FältnamnIndikatorerMetadata
00003845naa a2200613 4500
001oai:lup.lub.lu.se:67c09f43-d68f-4df3-b04c-4cb0279a3314
003SwePub
008160401s2009 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/14420722 URI
0247 a https://doi.org/10.1093/hmg/ddp1692 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Choquet, Helene4 aut
2451 0a The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49 279 subjects
264 c 2009-04-18
264 1b Oxford University Press (OUP),c 2009
520 a A recent study reported an association between the brain natriuretic peptide (BNP) promoter T-381C polymorphism (rs198389) and protection against type 2 diabetes (T2D). As replication in several studies is mandatory to confirm genetic results, we analyzed the T-381C polymorphism in seven independent case-control cohorts and in 291 T2D-enriched pedigrees totalling 39 557 subjects of European origin. A meta-analysis of the seven case-control studies (n = 39 040) showed a nominal protective effect [odds ratio (OR) = 0.86 (0.79-0.94), P = 0.0006] of the CC genotype on T2D risk, consistent with the previous study. By combining all available data (n = 49 279), we further confirmed a modest contribution of the BNP T-381C polymorphism for protection against T2D [OR = 0.86 (0.80-0.92), P = 1.4 x 10(-5)]. Potential confounders such as gender, age, obesity status or family history were tested in 4335 T2D and 4179 normoglycemic subjects and they had no influence on T2D risk. This study provides further evidence of a modest contribution of the BNP T-381C polymorphism in protection against T2D and illustrates the difficulty of unambiguously proving modest-sized associations even with large sample sizes.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
7001 a Cavalcanti-Proenca, Christine4 aut
7001 a Lecoeur, Cecile4 aut
7001 a Dina, Christian4 aut
7001 a Cauchi, Stephane4 aut
7001 a Vaxillaire, Martine4 aut
7001 a Hadjadj, Samy4 aut
7001 a Horber, Fritz4 aut
7001 a Potoczna, Natasha4 aut
7001 a Charpentier, Guillaume4 aut
7001 a Ruiz, Juan4 aut
7001 a Hercberg, Serge4 aut
7001 a Maimaitiming, Suliya4 aut
7001 a Roussel, Ronan4 aut
7001 a Boenhnke, Michael4 aut
7001 a Jackson, Anne U.4 aut
7001 a Patsch, Wolfgang4 aut
7001 a Krempler, Franz4 aut
7001 a Voight, Benjamin F.4 aut
7001 a Altshuler, David4 aut
7001 a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr
7001 a Thorleifsson, Gudmar4 aut
7001 a Steinthorsdottir, Valgerdur4 aut
7001 a Stefansson, Kari4 aut
7001 a Balkau, Beverley4 aut
7001 a Froguel, Philippe4 aut
7001 a Meyre, David4 aut
7102 a Genomik, diabetes och endokrinologib Forskargrupper vid Lunds universitet4 org
7730 t Human Molecular Geneticsd : Oxford University Press (OUP)g 18:13, s. 2495-2501q 18:13<2495-2501x 0964-6906x 1460-2083
8564 u http://dx.doi.org/10.1093/hmg/ddp169y FULLTEXT
8564 u https://academic.oup.com/hmg/article-pdf/18/13/2495/17246549/ddp169.pdf
8564 8u https://lup.lub.lu.se/record/1442072
8564 8u https://doi.org/10.1093/hmg/ddp169

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