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Sökning: onr:"swepub:oai:DiVA.org:umu-144812" > Indoor bacteria and...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005651naa a2200541 4500
001oai:DiVA.org:umu-144812
003SwePub
008180215s2018 | |||||||||||000 ||eng|
009oai:DiVA.org:uu-346883
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1448122 URI
0247 a https://doi.org/10.1183/13993003.01241-20172 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3468832 URI
040 a (SwePub)umud (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Pekkanen, Juhau Univ Helsinki, Dept Publ Hlth, Helsinki, Finland.;Natl Inst Hlth & Welf, Living Environm & Hlth Unit, Kuopio, Finland.4 aut
2451 0a Indoor bacteria and asthma in adults :b a multicentre case-control study within ECRHS II
264 c 2018-02-07
264 1b European Respiratory Society (ERS),c 2018
338 a print2 rdacarrier
520 a Both protective and adverse effects of indoor microbial exposure on asthma have been reported, but mostly in children. To date, no study in adults has used non-targeted methods for detection of indoor bacteria followed by quantitative confirmation. A cross-sectional study of 198 asthmatic and 199 controls was conducted within the European Community Respiratory Health Survey (ECRHS) II. DNA was extracted from mattress dust for bacterial analysis using denaturing gradient gel electrophoresis (DGGE). Selected bands were sequenced and associations with asthma confirmed with four quantitative PCR (qPCR) assays. 15 out of 37 bands detected with DGGE, which had at least a suggestive association (p<0.25) with asthma, were sequenced. Of the four targeted qPCRs, Clostridium cluster XI confirmed the protective association with asthma. The association was dose dependent (aOR 0.43 (95% CI 0.22-0.84) for the fourth versus first quartile, p for trend 0.009) and independent of other microbial markers. Few significant associations were observed for the three other qPCRs used. In this large international study, the level of Clostridium cluster XI was independently associated with a lower risk of prevalent asthma. Results suggest the importance of environmental bacteria also in adult asthma, but need to be confirmed in future studies.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng
7001 a Valkonen, Mariau Natl Inst Hlth & Welf, Living Environm & Hlth Unit, Kuopio, Finland.;Univ Eastern Finland, Dept Environm & Biol Sci, Kuopio, Finland.4 aut
7001 a Täubel, Martinu Natl Inst Hlth & Welf, Living Environm & Hlth Unit, Kuopio, Finland.4 aut
7001 a Tischer, Christinau ISGlobal, Barcelona Inst Global Hlth, Barcelona, Spain.;Univ Pompeu Fabra, Barcelona, Spain.;CIBER Epidemiol Salud Publ, CIBERESP, Madrid, Spain.4 aut
7001 a Leppänen, Hannau Natl Inst Hlth & Welf, Living Environm & Hlth Unit, Kuopio, Finland.4 aut
7001 a Kärkkäinen, Päivi Mu Natl Inst Hlth & Welf, Living Environm & Hlth Unit, Kuopio, Finland.4 aut
7001 a Rintala, Helenau Natl Inst Hlth & Welf, Living Environm & Hlth Unit, Kuopio, Finland.4 aut
7001 a Zock, Jan-Paulu ISGlobal, Barcelona Inst Global Hlth, Barcelona, Spain.;Univ Pompeu Fabra, Barcelona, Spain.;CIBER Epidemiol Salud Publ, CIBERESP, Madrid, Spain.4 aut
7001 a Casas, Lidiau Katholieke Univ Leuven, Ctr Environm & Hlth, Dept Publ Hlth & Primary Care, Leuven, Belgium.4 aut
7001 a Probst-Hensch, Nicoleu Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland.;Univ Basel, Dept Publ Hlth, Basel, Switzerland.4 aut
7001 a Forsberg, Bertilu Umeå universitet,Yrkes- och miljömedicin,Umea Univ, Dept Publ Hlth & Clin Med Occupat & Environm Me, Umea, Sweden.4 aut0 (Swepub:umu)befo0001
7001 a Holm, Mathiasu Sahlgrens Univ Hosp, Dept Occupat & Environm Med, Gothenburg, Sweden.4 aut
7001 a Janson, Christeru Uppsala universitet,Lung- allergi- och sömnforskning4 aut0 (Swepub:uu)chrisjn
7001 a Pin, Isabelleu Univ Grenoble Alpes, CHU Grenoble Alpes, Grenoble, France.4 aut
7001 a Gislason, Thorarinnu Landspitali Univ Hosp, Dept Resp Med & Sleep, E7, Reykjavik, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland.4 aut
7001 a Jarvis, Debbieu Natl Heart & Lung Inst, Imperial Coll, Populat Hlth & Occupat Dis, London, England.;Imperial Coll, MRC PHE Ctr Environm & Hlth, London, England.4 aut
7001 a Heinrich, Joachimu Ludwig Maximillians Univ Munich, Univ Hosp Munich, Inst & Outpatient Clin Occupat Social & Environm, Munich, Germany.;German Res Ctr Environm Hlth, Inst Epidemiol 1, Helmholtz Zentrum Munchen, Neuherberg, Germany.4 aut
7001 a Hyvärinen, Anneu Univ Helsinki, Dept Publ Hlth, Helsinki, Finland.4 aut
7102 a Univ Helsinki, Dept Publ Hlth, Helsinki, Finland.;Natl Inst Hlth & Welf, Living Environm & Hlth Unit, Kuopio, Finland.b Natl Inst Hlth & Welf, Living Environm & Hlth Unit, Kuopio, Finland.;Univ Eastern Finland, Dept Environm & Biol Sci, Kuopio, Finland.4 org
7730 t European Respiratory Journald : European Respiratory Society (ERS)g 51:2q 51:2x 0903-1936x 1399-3003
8564 u https://erj.ersjournals.com/content/erj/51/2/1701241.full.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-144812
8564 8u https://doi.org/10.1183/13993003.01241-2017
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-346883

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