WFRF:(Tydén Jonas)
Sökning: WFRF:(Tydén Jonas) > (2006-2009) > The platelet inhibi...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03826naa a2200397 4500 | |
| 001 | oai:DiVA.org:uu-24441 | |
| 003 | SwePub | |
| 008 | 070215s2007 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-244412 URI |
| 024 | 7 | a https://doi.org/10.1016/j.thromres.2006.10.0092 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Alström, Ulricau Uppsala universitet,Institutionen för kirurgiska vetenskaper4 aut0 (Swepub:uu)ulals788 |
| 245 | 1 0 | a The platelet inhibiting effect of a clopidogrel bolus dose in patients on long-term acetylsalicylic acid treatment |
| 264 | 1 | b Elsevier BV,c 2007 |
| 338 | a print2 rdacarrier | |
| 520 | a INTRODUCTION: Addition of clopidogrel to patients treated with ASA has been shown to decrease the incidence of in-stent thrombosis after percutaneous coronary interventions. However, it has also been reported that up to 30% of patients do not achieve adequate platelet inhibition from standard dosages of ASA and clopidogrel. There is a demand for reliable methods to measure the individual platelet inhibiting effect of this combination therapy. MATERIALS AND METHODS: The primary aim of the present investigation was to compare three methods for evaluation of the platelet inhibiting effect of a clopidogrel bolus dose in patients on long-term acetylsalicylic acid treatment. Thirty patients presenting for coronary angiography/PCI were included. Two patients were excluded due to technical problems. All patients were on 75-100 mg ASA/day for at least 8 days. Blood samples were analysed before and 16 h after a 300 mg clopidogrel bolus dose. The platelet inhibiting effect was measured with (1) Whole blood flow cytometry (17 patients); (2) a bed-side test, Platelet Mapping assay for the thrombelastograph (28 patients); and (3) PFA (Platelet function analyser) -100 (26 patients). RESULTS: With flow cytometry, the percentage of platelets expressing P-selectin (p=0.03) on their surface decreased significantly after the bolus dose of clopidogrel. There was also a reduction of platelets binding fibrinogen when stimulated with ADP. A significantly (p=0.002) increased platelet inhibition could also be demonstrated with Platelet Mapping. PFA-100 could not measure any significant platelet inhibiting effect of clopidogrel. CONCLUSION: A significant platelet inhibition could be demonstrated with flow cytometry and the Platelet Mapping assay, but not with PFA-100. However, levels of response for the individual patient with these three methods were inconsistent. Further studies are needed to evaluate how the results correlate to the clinical risk of thrombosis and bleeding. | |
| 653 | a Clopidogrel | |
| 653 | a Flow cytometry | |
| 653 | a Thrombelastograph | |
| 653 | a Platelets | |
| 653 | a PFA-100 | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Tydén, Hans4 aut |
| 700 | 1 | a Oldgren, Jonas,d 1964-u Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala kliniska forskningscentrum (UCR),UCR4 aut0 (Swepub:uu)jonaoldg |
| 700 | 1 | a Siegbahn, Agneta,d 1947-u Uppsala universitet,Klinisk kemi4 aut0 (Swepub:uu)agsie424 |
| 700 | 1 | a Ståhle, Elisabethu Uppsala universitet,Institutionen för kirurgiska vetenskaper4 aut0 (Swepub:uu)elsta102 |
| 710 | 2 | a Uppsala universitetb Institutionen för kirurgiska vetenskaper4 org |
| 773 | 0 | t Thrombosis Researchd : Elsevier BVg 120:3, s. 353-359q 120:3<353-359x 0049-3848x 1879-2472 |
| 856 | 4 | u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=17137616&dopt=Citation |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-24441 |
| 856 | 4 8 | u https://doi.org/10.1016/j.thromres.2006.10.009 |
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