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Molecular profiles of small cell lung cancer subtypes : therapeutic implications

Schwendenwein, Anna (författare)
Medical University of Vienna
Megyesfalvi, Zsolt (författare)
Medical University of Vienna,Semmelweis University,National Korányi Institute for Tuberculosis and Pulmonology, Hungary,National Institute of Oncology, Budapest
Barany, Nandor (författare)
Semmelweis University,Medical University of Vienna,National Korányi Institute for Tuberculosis and Pulmonology, Hungary
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Valko, Zsuzsanna (författare)
Medical University of Vienna,National Korányi Institute for Tuberculosis and Pulmonology, Hungary
Bugyik, Edina (författare)
National Korányi Institute for Tuberculosis and Pulmonology, Hungary
Lang, Christian (författare)
Medical University of Vienna
Ferencz, Bence (författare)
National Korányi Institute for Tuberculosis and Pulmonology, Hungary,Semmelweis University,National Institute of Oncology, Budapest
Paku, Sandor (författare)
Semmelweis University
Lantos, Andras (författare)
National Korányi Institute for Tuberculosis and Pulmonology, Hungary
Fillinger, Janos (författare)
National Institute of Oncology, Budapest,Semmelweis University,National Korányi Institute for Tuberculosis and Pulmonology, Hungary
Rezeli, Melinda (författare)
Lund University,Lunds universitet,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Clinical Protein Science and Imaging,Forskargrupper vid Lunds universitet,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH,Lund University Research Groups
Marko-Varga, Gyorgy (författare)
Lund University,Lunds universitet,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Clinical Protein Science and Imaging,Forskargrupper vid Lunds universitet,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH,Lund University Research Groups
Bogos, Krisztina (författare)
National Korányi Institute for Tuberculosis and Pulmonology, Hungary
Galffy, Gabriella (författare)
Torokbalint County Institute of Pulmonology
Renyi-Vamos, Ferenc (författare)
Semmelweis University,National Institute of Oncology, Budapest,National Korányi Institute for Tuberculosis and Pulmonology, Hungary
Hoda, Mir Alireza (författare)
Medical University of Vienna
Klepetko, Walter (författare)
Medical University of Vienna
Hoetzenecker, Konrad (författare)
Medical University of Vienna
Laszlo, Viktoria (författare)
National Korányi Institute for Tuberculosis and Pulmonology, Hungary,Semmelweis University,Medical University of Vienna,National Institute of Oncology, Budapest
Dome, Balazs (författare)
Medical University of Vienna,National Korányi Institute for Tuberculosis and Pulmonology, Hungary,Semmelweis University,National Institute of Oncology, Budapest
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 (creator_code:org_t)
Elsevier BV, 2021
2021
Engelska 14 s.
Ingår i: Molecular Therapy - Oncolytics. - : Elsevier BV. - 2372-7705. ; 20, s. 470-483
Relaterad länk:
http://dx.doi.org/10... (free)
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http://www.cell.com/...
https://lup.lub.lu.s...
https://doi.org/10.1...
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  • Forskningsöversikt (refereegranskat)
Abstract Ämnesord
Stäng  
  • Small cell lung cancer (SCLC; accounting for approximately 13%–15% of all lung cancers) is an exceptionally lethal malignancy characterized by rapid doubling time and high propensity to metastasize. In contrast to the increasingly personalized therapies in other types of lung cancer, SCLC is still regarded as a homogeneous disease and the prognosis of SCLC patients remains poor. Recently, however, substantial progress has been made in our understanding of SCLC biology. Advances in genomics and development of new preclinical models have facilitated insights into the intratumoral heterogeneity and specific genetic alterations of this disease. This worldwide resurgence of studies on SCLC has ultimately led to the development of novel subtype-specific classifications primarily based on the neuroendocrine features and distinct molecular profiles of SCLC. Importantly, these biologically distinct subtypes might define unique therapeutic vulnerabilities. Herein, we summarize the current knowledge on the molecular profiles of SCLC subtypes with a focus on their potential clinical implications. Small cell lung cancer is still regarded as a homogeneous disease associated with poor prognosis. Recent analysis, however, has led to the development of novel subtype-specific classifications primarily based on the neuroendocrine features and molecular profiles. The better understanding of these biologically distinct subtypes might help to define unique therapeutic vulnerabilities.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

heterogeneity
molecular profile
neuroendocrine
small cell lung cancer

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